KIF15 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | KIF15 , HKLP2, KNSL7, NY-BR-62, kinesin family member 15, KLP2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 617569; MGI: 1098258; HomoloGene: 23210; GeneCards: KIF15; OMA:KIF15 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene. [5]
This gene encodes a motor protein that is part of the kinesin superfamily. KIF15 maintains half spindle separation by opposing forces generated by other motor proteins. KIF15 co-localizes with microtubules and actin filaments in both dividing cells and in postmitotic neurons. [5]
KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth. [6] KIF15 maintains bipolar microtubule spindle apparatus in dividing cells and shares redundant functions with KIF11. [7] KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between centrosomes. The microtubule localization of Kif15 is being regulated by Kinesin binding protein (KBP). [8] HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner. [9] [10] Hence, inhibition of KIF15 function will be a vital therapeutic approach in cancer chemotherapy. [11] Since KIF11 and KIF15 are functionally redundant, drugs targeting both the proteins will be more potent. [8]
KIF15 restricts the movement of short microtubules into growing axons by generating forces on microtubules which counteract those generated by cytoplasmic dynein. [12] [13] KIF15, together with KIF23 become enriched in dendrites as neurons mature to promote the transport of minus-end distal microtubules into nascent dendrites. [12]
KIF15 has been shown to interact with TPX2. Both these dimers cooperate to slide along microtubules and maintain bipolar spindles. [14] [15]