KRT86 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | KRT86 , HB6, Hb1, KRTHB1, KRTHB6, MNX, hHb6, K86, keratin 86 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601928; MGI: 109362; HomoloGene: 1717; GeneCards: KRT86; OMA:KRT86 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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The KRT86 gene encodes for keratin, type II cuticular Hb6 protein in humans. [5] [6] [7]
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRT81, KRT83, and KRT86, is highly related. The other, less-related subfamily includes KRT82, KRT84, and KRT85. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRT81 and KRT83, is found primarily in the hair cortex. Mutations in this gene and KRT81 have been observed in patients with a rare dominant hair disease, monilethrix. [7]