KRT77

keratin 77
keratin 77
Identifiers
Symbol	KRT77
Alt. symbols	KRT1B
NCBI gene	374454
HGNC	20411
RefSeq	NM_175078
Other data
Locus	Chr. 12 q13.13

Last updated October 05, 2025

KRT77 encodes keratin 77, a member of the type II keratin family of intermediate filament proteins. Keratin 77 is also known as KRT1B, Type II cytoskeletal 1b, Type II keratin Kb39, and cytokeratin 1B. KRT77 is well-expressed by granular layer epidermal keratinocytes except for those that reside at acral surfaces.^[1] There is little to no expression of KRT77 in acral keratinocytes.^[1]

References

1 2 Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16) e159762. doi:10.1172/jci.insight.159762. PMC 9462509 . PMID 35900871.

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[:0-1] 1 2 Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16) e159762. doi:10.1172/jci.insight.159762. PMC 9462509 . PMID 35900871.

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