KRT23

KRT23
Identifiers
Aliases	KRT23 , CK23, HAIK1, K23, keratin 23
External IDs	OMIM: 606194; MGI: 2148866; HomoloGene: 9172; GeneCards: KRT23; OMA:KRT23 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,937,646 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,383,963 bp
RNA expression pattern
	Top expressed in
	placenta; ; skin of leg; ; skin of abdomen; ; olfactory zone of nasal mucosa; ; salivary gland; ; minor salivary glands; ; blood; ; islet of Langerhans; ; tonsil; ; right uterine tube;
	Top expressed in
	otic placode; ; esophagus; ; epithelium of stomach; ; lip; ; submandibular gland; ; skin of back; ; saccule; ; parotid gland; ; mucous cell of stomach; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity ;
Cellular component	intermediate filament ; cytosol ;
Biological process	keratinization ; cornification ;
	Sources:Amigo / QuickGO
Orthologs
	25984
	94179
	ENSG00000108244 ; ENSG00000263309
	ENSMUSG00000006777
	Q9C075
	Q99PS0
	NM_001282433 ; NM_015515 ; NM_173213
	NM_033373
	NP_001269362 ; NP_056330
	NP_203537
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 15, 2024

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratin and hair keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.^[7]

Related Research Articles

Keratin, type II cytoskeletal 7 also known as cytokeratin-7 (CK-7) or keratin-7 (K7) or sarcolectin (SCL) is a protein that in humans is encoded by the KRT7 gene. Keratin 7 is a type II keratin. It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

Keratin 6A is one of the 27 different type II keratins expressed in humans. Keratin 6A was the first type II keratin sequence determined. Analysis of the sequence of this keratin together with that of the first type I keratin led to the discovery of the four helical domains in the central rod of keratins. In humans Keratin 6A is encoded by the KRT6A gene.

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.

Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined. Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene.

Keratin 13 is a protein that in humans is encoded by the KRT13 gene.

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.

Keratin 9 is a protein that in humans is encoded by the KRT9 gene.

Keratin, type I cytoskeletal 19 (Keratin-19)) also known as cytokeratin-19 (CK-19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin-19 is a type I keratin.

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Keratin 15 is a protein that in humans is encoded by the KRT15 gene. It has also been referred to as cytokeratin 15, K1CO and KRTB.

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.

Periplakin is a protein that in humans is encoded by the PPL gene.

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.

LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene.

Neurabin-1 is a protein that in humans is encoded by the PPP1R9A gene.

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.

Keratin 79 also known as KRT79 is a protein which humans is encoded by the KRT79 gene.

References

1 2 3 ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006777 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.
↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.
1 2 "KRT23 keratin 23 [ Homo sapiens (human) ]".

Suzuki A, Ji G, Numabe Y, et al. (2004). "Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese". Biochem. Biophys. Res. Commun. 317 (3): 887–92. doi:10.1016/j.bbrc.2004.03.126. PMID 15081423.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Tolstonog GV, Sabasch M, Traub P (2002). "Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function". DNA Cell Biol. 21 (3): 213–39. doi:10.1089/10445490252925459. PMID 12015898.
Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell Sci. 114 (Pt 14): 2569–75. doi:10.1242/jcs.114.14.2569. PMID 11683385.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006777 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11135429-5] Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.

[entrez-7] 1 2 "KRT23 keratin 23 [ Homo sapiens (human) ]".

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KRT23

Related Research Articles

References

Further reading