MYH7B

MYH7B
Identifiers
Aliases	MYH7B , MHC14, MYH14, myosin, heavy chain 7B, cardiac muscle, beta, myosin heavy chain 7B
External IDs	OMIM: 609928 MGI: 3710243 HomoloGene: 66117 GeneCards: MYH7B
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,002,437 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,634,307 bp
Gene ontology
Molecular function	• nucleotide binding ; • actin binding ; • cellular motor activity ; • GO:0001948 protein binding ; • ATP binding ; • actin filament binding ; • microtubule motor activity ; • microtubule binding ;
Cellular component	• myosin filament ; • membrane ; • myosin complex ; • cardiac myofibril ;
Biological process	• microtubule-based movement ;
	Sources:Amigo / QuickGO
Orthologs
	57644
	668940
	ENSG00000078814
	ENSMUSG00000074652
	Q5JW45
	A2AQP0
	NM_020884
	NM_001085378
	NP_065935
	NP_001078847
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 07, 2020

Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.^[5]^[6]

Function

MYH7B is a slow-twitch myosin.^[6]

Related Research Articles

Myosin-11 is a protein that in humans is encoded by the MYH11 gene.

Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene. This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is expressed predominantly in human cardiac atria, exhibiting only minor expression in human cardiac ventricles. It is the major protein comprising the cardiac muscle thick filament, and functions in cardiac muscle contraction. Mutations in MYH6 have been associated with late-onset hypertrophic cardiomyopathy, atrial septal defects and sick sinus syndrome.

Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.

Myosin-2 is a protein that in humans is encoded by the MYH2 gene.

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.

E3 ubiquitin-protein ligase TRIM63, also known as "MuRF1" is an enzyme that in humans is encoded by the TRIM63 gene.

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.

SPEG complex locus, also known as SPEG, is a human gene.

Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.

Myosin-3 is a protein that in humans is encoded by the MYH3 gene.

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.

Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.

Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.

Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078814 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074652 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID 10819331.
1 2 Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi: 10.1093/oxfordjournals.molbev.a004093 . PMID 11919279.

Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles". J. Physiol. 588 (Pt 2): 353–64. doi:10.1113/jphysiol.2009.181008. PMC 2821527 . PMID 19948655.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi: 10.1038/414865a . PMID 11780052.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. Biol. Evol. 21 (6): 1042–56. doi: 10.1093/molbev/msh103 . PMID 15014174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Hu Z, Liang J, Wang Z, et al. (2009). "Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women". Hum. Mutat. 30 (1): 79–84. doi:10.1002/humu.20837. PMID 18634034. S2CID 41225773.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000078814 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074652 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID 10819331.

[pmid11919279-6] 1 2 Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi: 10.1093/oxfordjournals.molbev.a004093 . PMID 11919279.

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MYH7B

Contents

Function

Related Research Articles

References

Further reading