FLNB | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | FLNB , ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP, filamin B | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603381; MGI: 2446089; HomoloGene: 37480; GeneCards: FLNB; OMA:FLNB - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Filamin B, beta (FLNB), also known as Filamin B, beta (truncated actin binding protein 278 homolog), is a cytoplasmic protein which in humans is encoded by the FLNB gene.
FLNB regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network, to control and guide proper skeletal development. [5]
Mutations in the FLNB gene are involved in several lethal bone dysplasias, including boomerang dysplasia and atelosteogenesis type I. [6] [7] [8]
FLNB has been shown to interact with GP1BA, [9] Filamin, [10] FBLIM1, [11] PSEN1, [12] CD29 [13] and PSEN2. [12]
Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene.
Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.
Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.
5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.
Gamma-crystallin D is a protein that in humans is encoded by the CRYGD gene.
Beta-adducin is a protein that in humans is encoded by the ADD2 gene.
Delta-sarcoglycan is a protein that in humans is encoded by the SGCD gene.
Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.
For the SSH-1 protocol, see Secure Shell#Version 1
Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.
Vinexin is a protein that in humans is encoded by the SORBS3 gene.
Myosin-14 is a protein that in humans is encoded by the MYH14 gene.
Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.
Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.
Sodium/hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.
The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.