MAPRE3

MAPRE3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYO, 3CO1, 3JAK, 3JAL, 3JAR, 3TQ7
Identifiers
Aliases	MAPRE3 , EB3, EBF3, EBF3-S, RP3, microtubule associated protein RP/EB family member 3
External IDs	OMIM: 605788 MGI: 2140967 HomoloGene: 56565 GeneCards: MAPRE3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,027,219 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,023,450 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; right uterine tube; ; middle frontal gyrus; ; frontal pole; ; cingulate gyrus; ; anterior pituitary; ; cerebellar vermis; ; nucleus accumbens; ; Brodmann area 9; ; amygdala;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; spermatid; ; entorhinal cortex; ; lip; ; dorsomedial hypothalamic nucleus; ; habenula; ; superior colliculus; ; primary motor cortex; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	microtubule binding ; protein binding ; identical protein binding ; protein C-terminus binding ; protein kinase binding ; microtubule plus-end binding ;
Cellular component	microtubule cytoskeleton ; microtubule plus-end ; perinuclear region of cytoplasm ; cytoplasmic microtubule ; midbody ; microtubule ; cytoskeleton ; cytoplasm ; microtubule organizing center ; spindle midzone ; mitotic spindle astral microtubule end ;
Biological process	positive regulation of transcription, DNA-templated ; cell cycle ; positive regulation of microtubule plus-end binding ; positive regulation of cyclin-dependent protein serine/threonine kinase activity ; cell division ; protein localization ; regulation of microtubule polymerization or depolymerization ; protein localization to microtubule ; positive regulation of protein kinase activity ; spindle assembly ; protein localization to microtubule plus-end ;
	Sources:Amigo / QuickGO
Orthologs
	22924
	100732
	ENSG00000084764
	ENSMUSG00000029166
	Q9UPY8
	Q6PER3
	NM_001303050 ; NM_012326
	NM_133350 ; NM_001310516
	NP_001289979 ; NP_036458
	NP_001297445 ; NP_579928
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 14, 2023

Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.^[5]^[6]

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.^[6]

Related Research Articles

Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer.

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene.

MHC class II regulatory factor RFX1 is a protein that, in humans, is encoded by the RFX1 gene located on the short arm of chromosome 19.

Microtubule-associated protein RP/EB family member 1 is a protein that in humans is encoded by the MAPRE1 gene.

Alpha-centractin (yeast) or ARP1 is a protein that in humans is encoded by the ACTR1A gene.

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.

Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.

Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene.

Oxygen-regulated protein 1 also known as retinitis pigmentosa 1 protein (RP1) is a protein that in humans is encoded by the RP1 gene.

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.

Dynein heavy chain 9, axonemal is a protein that in humans is encoded by the DNAH9 gene.

Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.

Myomegalin, also known as phosphodiesterase 4D-interacting protein or cardiomyopathy-associated protein 2, is a protein that in humans is encoded by the PDE4DIP gene. It has roles in the formation of microtubules from the centrosome. Its name derives from the fact that it is highly expressed in units of tubular myofibrils known as sarcomeres and is a large protein, at 2,324 amino acids. It was first characterised in 2000.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000084764 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029166 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi: 10.4049/jimmunol.159.3.1276 . PMID 9233623. S2CID 23797920.
1 2 "Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3".

Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi: 10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z . PMID 10188731. S2CID 33232892.
Nakagawa H, Koyama K, Murata Y, et al. (2000). "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue". Oncogene. 19 (2): 210–6. doi: 10.1038/sj.onc.1203308 . PMID 10644998.
Su LK, Qi Y (2001). "Characterization of human MAPRE genes and their proteins". Genomics. 71 (2): 142–9. doi:10.1006/geno.2000.6428. PMID 11161807.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. doi: 10.1074/jbc.M306194200 . PMID 14514668.
Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi: 10.1074/jbc.M311671200 . PMID 15117959.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674 . PMID 15631994.
Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi: 10.1242/jcs.02472 . PMID 16079286.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000084764 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029166 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9233623-5] Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi: 10.4049/jimmunol.159.3.1276 . PMID 9233623. S2CID 23797920.

[entrez-6] 1 2 "Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3".

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MAPRE3

Related Research Articles

References

Further reading