Centrin 2

CETN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M39, 1ZMZ, 2A4J, 2GGM, 2K2I, 2OBH
Identifiers
Aliases	CETN2 , CALT, CEN2, centrin 2
External IDs	OMIM: 300006 MGI: 1347085 HomoloGene: 55798 GeneCards: CETN2
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 152,826,994 bp [1] End 152,830,757 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X A7.3|X 37.29 cM Start 71,957,138 bp [2] End 71,962,017 bp [2]
RNA expression pattern Bgee Top expressed in cerebellum fallopian tube caput epididymis peritoneum pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heterotrimeric G-protein binding metal ion binding calcium ion binding G-protein beta/gamma-subunit complex binding microtubule binding GO:0001948 protein binding Cellular component photoreceptor connecting cilium centriole cytoplasm nucleoplasm ciliary basal body cytosol nucleus XPC complex centrosome intracellular anatomical structure cilium cytoskeleton microtubule organizing center nuclear pore nuclear basket transcription export complex 2 nuclear envelope nuclear pore Biological process nucleotide-excision repair, DNA damage recognition cell cycle spermatogenesis cell division G2/M transition of mitotic cell cycle regulation of cytokinesis centriole replication cellular response to DNA damage stimulus global genome nucleotide-excision repair nucleotide-excision repair, preincision complex assembly DNA repair nucleotide-excision repair ciliary basal body-plasma membrane docking GO:0007067 mitotic cell cycle regulation of G2/M transition of mitotic cell cycle mitotic cytokinesis regulation of centrosome duplication calcium-mediated signaling microtubule cytoskeleton organization nucleotide-excision repair, DNA duplex unwinding protein transport mRNA transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1069	26370
Ensembl	ENSG00000147400	ENSMUSG00000031347
UniProt	P41208	Q9R1K9
RefSeq (mRNA)	NM_004344	NM_019405
RefSeq (protein)	NP_004335	NP_062278
Location (UCSC)	Chr X: 152.83 – 152.83 Mb	Chr X: 71.96 – 71.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Centrin-2 is a protein that in humans is encoded by the CETN2 gene. ^{[5] [6] [7]} It belongs to the centrin family of proteins.

Centrin-2 belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that centrin-2 plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. ^[7]

Interactions

CETN2 has been shown to interact with XPC ^[8] and SFI1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000147400 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031347 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tanaka T, Okui K, Nakamura Y (May 1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization". Genomics. 24 (3): 609–10. PMID   7713520.
6. Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions". Mamm Genome. 6 (11): 802–4. doi:10.1007/BF00539008. PMID   8597638. S2CID   19420279.
7. "Entrez Gene: CETN2 centrin, EF-hand protein, 2".
8. Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. United States. 276 (22): 18665–72. doi: 10.1074/jbc.M100855200 . ISSN   0021-9258. PMID   11279143.
9. Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex". Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID   19857500.

External links

• Human CETN2 genome location and CETN2 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : P41208 (Centrin-2) at the PDBe-KB .

Further reading

• Lee VD, Huang B (1994). "Molecular cloning and centrosomal localization of human caltractin". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11039–43. Bibcode:1993PNAS...9011039L. doi: 10.1073/pnas.90.23.11039 . PMC   47917 . PMID   8248209.
• Wolfrum U, Salisbury JL (1998). "Expression of centrin isoforms in the mammalian retina". Exp. Cell Res. 242 (1): 10–7. doi:10.1006/excr.1998.4038. PMID   9665797. S2CID   8459226.
• Durussel I, Blouquit Y, Middendorp S, et al. (2000). "Cation- and peptide-binding properties of human centrin 2". FEBS Lett. 472 (2–3): 208–12. doi: 10.1016/S0014-5793(00)01452-6 . PMID   10788612.
• Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC   310879 . PMID   10854409.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Araki M, Masutani C, Takemura M, et al. (2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. 276 (22): 18665–72. doi: 10.1074/jbc.M100855200 . PMID   11279143.
• Salisbury JL, Suino KM, Busby R, Springett M (2003). "Centrin-2 is required for centriole duplication in mammalian cells". Curr. Biol. 12 (15): 1287–92. doi: 10.1016/S0960-9822(02)01019-9 . PMID   12176356.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Matei E, Miron S, Blouquit Y, et al. (2003). "C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain". Biochemistry. 42 (6): 1439–50. doi:10.1021/bi0269714. PMID   12578356.
• Gavet O, Alvarez C, Gaspar P, Bornens M (2004). "Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells". Mol. Biol. Cell. 14 (5): 1818–34. doi:10.1091/mbc.E02-11-0709. PMC   165080 . PMID   12802058.
• Popescu A, Miron S, Blouquit Y, et al. (2003). "Xeroderma pigmentosum group C protein possesses a high affinity binding site to human centrin 2 and calmodulin". J. Biol. Chem. 278 (41): 40252–61. doi: 10.1074/jbc.M302546200 . PMID   12890685.
• Kilmartin JV (2003). "Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication". J. Cell Biol. 162 (7): 1211–21. doi:10.1083/jcb.200307064. PMC   2173958 . PMID   14504268.
• Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Mol. Biol. Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC   379276 . PMID   14767062.
• Tourbez M, Firanescu C, Yang A, et al. (2005). "Calcium-dependent self-assembly of human centrin 2". J. Biol. Chem. 279 (46): 47672–80. doi: 10.1074/jbc.M404996200 . PMID   15356003.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Nishi R, Okuda Y, Watanabe E, et al. (2005). "Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein". Mol. Cell. Biol. 25 (13): 5664–74. doi:10.1128/MCB.25.13.5664-5674.2005. PMC   1156980 . PMID   15964821.