Keratin 9

Last updated

KRT9
Identifiers
Aliases KRT9 , CK-9, EPPK, K9, keratin 9
External IDs OMIM: 607606; MGI: 96696; HomoloGene: 133554; GeneCards: KRT9; OMA:KRT9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000226

NM_201255

RefSeq (protein)

NP_000217

NP_957707

Location (UCSC) Chr 17: 41.57 – 41.57 Mb Chr 11: 100.08 – 100.08 Mb
PubMed search [3] [4]
Wikidata
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Keratin 9 is a protein that in humans is encoded by the KRT9 gene. [5] [6]

Keratin 9 is a type I cytokeratin. It is found only in the terminally differentiated epidermis of palms and soles. Mutations in the gene encoding this protein cause epidermolytic palmoplantar keratoderma. [7]

Related Research Articles

<span class="mw-page-title-main">Keratin 1</span>

Keratin 1 is a Type II intermediate filament (IFs) of the intracytoplasmatic cytoskeleton. Is co-expressed with and binds to Keratin 10, a Type I keratin, to form a coiled coil heterotypic keratin chain. Keratin 1 and Keratin 10 are specifically expressed in the spinous and granular layers of the epidermis. In contrast, basal layer keratinocytes express little to no Keratin 1. Mutations in KRT1, the gene encoding Keratin 1, have been associated with variants of the disease bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected. Mutations in KRT10 have also been associated with bullous congenital ichthyosiform erythroderma; however, in patients with KRT10 mutations the palms and soles are spared. This difference is likely due to Keratin 9, rather than Keratin 10, being the major binding partner of Keratin 1 in acral keratinocytes.

<span class="mw-page-title-main">Keratin 4</span>

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.

<span class="mw-page-title-main">Keratin 2A</span>

Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene.

<span class="mw-page-title-main">Keratin 12</span> Protein-coding gene in the species Homo sapiens

Keratin 12 is a protein that in humans is encoded by the KRT12 gene. It's a type I keratin.

<span class="mw-page-title-main">Keratin 10</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.

<span class="mw-page-title-main">Keratin 18</span>

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

<span class="mw-page-title-main">Keratin 17</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.

<span class="mw-page-title-main">Keratin 16</span> Protein-coding gene in the species Homo sapiens

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.

<span class="mw-page-title-main">Keratin 15</span> Protein-coding gene in the species Homo sapiens

Keratin 15 is a protein that in humans is encoded by the KRT15 gene. It has also been referred to as cytokeratin 15, K1CO and KRTB.

<span class="mw-page-title-main">Palmoplantar keratoderma</span> Abnormal thickening of skin in the palms or soles

Palmoplantar keratodermas are a heterogeneous group of skin disorders characterized by abnormal thickening (scleroderma) of the stratum corneum of the palms and soles.

<span class="mw-page-title-main">Keratin 6C</span>

Keratin 6C, is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. This gene was uncovered recently by the Human Genome Project and its expression patterns in humans remains unknown.

<span class="mw-page-title-main">Loricrin</span> Protein-coding gene in the species Homo sapiens

Loricrin is a protein that in humans is encoded by the LOR gene.

<span class="mw-page-title-main">KRT81</span>

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.

<span class="mw-page-title-main">KRT86</span>

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.

<span class="mw-page-title-main">KRT78</span>

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

<span class="mw-page-title-main">KRT33B</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cuticular Ha3-II is a protein that in humans is encoded by the KRT33B gene.

<span class="mw-page-title-main">KRT32</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.

<span class="mw-page-title-main">KRT33A</span> Protein-coding gene in the species Homo sapiens

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.

<span class="mw-page-title-main">KRT85</span>

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.

Howel–Evans syndrome is an extremely rare condition involving thickening of the skin in the palms of the hands and the soles of the feet (hyperkeratosis). This familial disease is associated with a high lifetime risk of esophageal cancer. For this reason, it is sometimes known as tylosis with oesophageal cancer (TOC).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171403 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051617 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Langbein L, Heid HW, Moll I, Franke WW (December 1993). "Molecular characterization of the body site-specific human epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and tissue specificity of gene expression". Differentiation. 55 (1): 57–71. doi:10.1111/j.1432-0436.1993.tb00033.x. PMID   7507869.
  6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC   2064177 . PMID   16831889.
  7. Reis A, Hennies HC, Langbein L, Digweed M, Mischke D, Drechsler M, Schröck E, Royer-Pokora B, Franke WW, Sperling K (February 1994). "Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK)". Nat. Genet. 6 (2): 174–9. doi:10.1038/ng0294-174. PMID   7512862. S2CID   31277241.

Further reading