TGS1

TGS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EGI, 3GDH
Identifiers
Aliases	TGS1 , NCOA6IP, PIMT, PIPMT, trimethylguanosine synthase 1
External IDs	OMIM: 606461; MGI: 2151797; HomoloGene: 32608; GeneCards: TGS1; OMA:TGS1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q12.1 Start 55,773,446 bp [1] End 55,826,445 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 A1|4 1.99 cM Start 3,574,875 bp [2] End 3,616,619 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii oocyte secondary oocyte Achilles tendon nipple tail of epididymis pylorus internal globus pallidus renal medulla corpus epididymis Top expressed in tail of embryo condyle cumulus cell genital tubercle ureter primitive streak pineal gland renal corpuscle fossa abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity RNA trimethylguanosine synthase activity protein binding RNA methyltransferase activity Cellular component cytoplasm Cajal body nucleoplasm nucleolus small nuclear ribonucleoprotein complex nucleus extracellular space cytosol Biological process regulation of transcription, DNA-templated transcription, DNA-templated spliceosomal snRNP assembly methylation 7-methylguanosine RNA capping 7-methylguanosine cap hypermethylation ribonucleoprotein complex biogenesis RNA methylation regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 96764 116940 Ensembl ENSG00000137574 ENSMUSG00000028233 UniProt Q96RS0 Q923W1 RefSeq (mRNA) NM_024831 NM_001317902 NM_001363184 NM_054089 RefSeq (protein) NP_001304831 NP_079107 NP_001350113 NP_473430 Location (UCSC) Chr 8: 55.77 – 55.83 Mb Chr 4: 3.57 – 3.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene. ^{[5] [6] [7]}

Interactions

TGS1 has been shown to interact with:

• CREB-binding protein, ^[8] and
• EED, ^[9]
• EP300, ^[8]
• MED1, ^[8] and
• NCOA6. ^{[5] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000137574 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028233 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A. 98 (18): 10380–5. Bibcode:2001PNAS...9810380Z. doi: 10.1073/pnas.181347498 . PMC   56969 . PMID   11517327.
6. Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R (May 2002). "Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus". Mol Cell. 9 (4): 891–901. doi: 10.1016/S1097-2765(02)00484-7 . PMID   11983179.
7. "Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)".
8. Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi: 10.1074/jbc.M201739200 . PMID   11912212.
9. Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/s0006-291x(03)01514-6. PMID   12943661.

Further reading

• Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi: 10.1074/jbc.M201739200 . PMID   11912212.
• Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E (2002). "Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments". EMBO J. 21 (11): 2736–45. doi:10.1093/emboj/21.11.2736. PMC   126019 . PMID   12032086.
• Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi: 10.4049/jimmunol.169.2.1102 . PMID   12097419.
• Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. Bibcode:2002PNAS...9911836S. doi: 10.1073/pnas.182426699 . PMC   129355 . PMID   12189208.
• Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG (2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood. 100 (6): 2123–31. doi: 10.1182/blood-2002-02-0513 . PMID   12200376.
• Mouaikel J, Narayanan U, Verheggen C, Matera AG, Bertrand E, Tazi J, Bordonné R (2004). "Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron". EMBO Rep. 4 (6): 616–22. doi:10.1038/sj.embor.embor863. PMC   1319203 . PMID   12776181.
• Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. PMID   12943661.
• Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, Lührmann R (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. hdl: 11858/00-001M-0000-0012-EB89-8 . PMID   15574333.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.