TRIM3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TRIM3 , BERP, HAC1, RNF22, RNF97, tripartite motif containing 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605493 MGI: 1860040 HomoloGene: 21290 GeneCards: TRIM3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene. [5] [6]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [6]
TRIM3 has been shown to interact with Actinin alpha 4. [7]
TRIM3 binds to and ubiquitinates Estrogen receptor alpha (ERa) leading to receptor's stabilization. [8]
Moreover, TRIM3 interacts with P53 which promotes the formation of K48-linked poly-ubiquitin chains and degradation. [9]
Tripartite motif-containing protein 5 also known as RING finger protein 88 is a protein that in humans is encoded by the TRIM5 gene. The alpha isoform of this protein, TRIM5α, is a retrovirus restriction factor, which mediates a species-specific early block to retrovirus infection.
Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. In humans it is coded for by the MYO5A gene.
Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1, is a protein that in humans is encoded by the TRIM28 gene.
Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.
Tripartite motif-containing protein 21, also known as E3 ubiquitin-protein ligase TRIM21, is a protein that in humans is encoded by the TRIM21 gene. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. It is expressed in most human tissues.
Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.
Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.
Tripartite motif-containing protein 37 is an E3 ubiquitin ligase in humans that is encoded by the TRIM37 gene.
Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.
Midline-2 is a protein that in humans is encoded by the MID2 gene.
Tripartite motif-containing protein 32 is a protein that in humans is encoded by the TRIM32 gene. Since its discovery in 1995, TRIM32 has been shown to be implicated in a number of diverse biological pathways.
Tripartite motif-containing 22, also known as TRIM22, is a protein which in humans is encoded by the TRIM22 gene.
Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene.
E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.
Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.
Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.
Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.
Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.
Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.
Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.