TRIM69

TRIM69
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NQJ
Identifiers
Aliases	TRIM69 , HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
External IDs	OMIM: 616017 MGI: 1918178 HomoloGene: 18827 GeneCards: TRIM69
Gene location (Human)
Chr.	Chromosome 15 (human)
End	44,767,829 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,009,508 bp
RNA expression pattern
	Top expressed in
	thymus; ; prefrontal cortex; ; skeletal muscle tissue; ; putamen; ; left ventricle; ; caudate nucleus; ; dorsolateral prefrontal cortex; ; nucleus accumbens; ; substantia nigra; ; superior frontal gyrus;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; morula; ; jejunum; ; endocrine system; ; pancreas; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; metal ion binding ; ubiquitin-protein transferase activity ; transferase activity ;
Cellular component	cytoplasm ; nuclear speck ; nucleus ; cytosol ;
Biological process	protein ubiquitination ; apoptotic process ; protein polyubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	140691
	70928
	ENSG00000278211 ; ENSG00000185880
	ENSMUSG00000033368
	Q86WT6
	Q80X56
	NM_182985 ; NM_001301144 ; NM_001301145 ; NM_001301146 ; NM_080745 Contents Function ; References ; External links ; Further reading ;
	NM_080510 ; NM_001379369
	NP_001288073 ; NP_001288074 ; NP_001288075 ; NP_542783 ; NP_892030
	NP_536771 ; NP_001366298
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. ^[5]

Function

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Related Research Articles

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.

Tripartite motif-containing protein 37 is an E3 ubiquitin ligase in humans that is encoded by the TRIM37 gene.

Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

Tripartite motif-containing 22, also known as TRIM22, is a protein which in humans is encoded by the TRIM22 gene.

Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene.

E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.

Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.

Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.

Tripartite motif containing 65 is a protein that in humans is encoded by the TRIM65 gene.

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.

Tripartite motif containing 34 is a protein that, in humans, is encoded by the TRIM34 gene.

Ring finger protein 19B is a protein that in humans is encoded by the RNF19B gene.

Tripartite motif containing 38 is a protein that in humans is encoded by the TRIM38 gene.

References

1 2 3 ENSG00000185880 GRCh38: Ensembl release 89: ENSG00000278211, ENSG00000185880 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033368 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Tripartite motif containing 69" . Retrieved 2016-02-16.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69

TRIM69

Contents

Function

Related Research Articles

References

External links

Further reading