TRIM68

TRIM68
Identifiers
Aliases	TRIM68 , GC109, RNF137, SS-56, SS56, tripartite motif containing 68
External IDs	OMIM: 613184 MGI: 2142077 HomoloGene: 9991 GeneCards: TRIM68
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 4,598,672 bp [1] End 4,608,231 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 102,326,789 bp [2] End 102,336,534 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva bronchial epithelial cell prostate right lobe of thyroid gland glomerulus metanephric glomerulus parietal pleura left lobe of thyroid gland ovary canal of the cervix Top expressed in mucosa of urinary bladder retinal pigment epithelium mammary gland Paneth cell urethra superior cervical ganglion hair follicle male urethra lacrimal gland hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding androgen receptor binding histone acetyltransferase binding metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm perinuclear region of cytoplasm Golgi apparatus nucleolus intracellular anatomical structure nucleus cytosol Biological process interferon-gamma-mediated signaling pathway regulation of androgen receptor signaling pathway protein ubiquitination protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55128 101700 Ensembl ENSG00000167333 ENSMUSG00000073968 UniProt Q6AZZ1 Q8K243 RefSeq (mRNA) NM_018073 NM_001304496 NM_198012 NM_001307998 RefSeq (protein) NP_001291425 NP_060543 n/a Location (UCSC) Chr 11: 4.6 – 4.61 Mb Chr 7: 102.33 – 102.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene. ^{[5] [6]}

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells. ^[6]

Interactions

TRIM68 has been shown to interact with Androgen receptor. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000167333 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073968 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chang GT, Steenbeek M, Schippers E, Blok LJ, van Weerden WM, van Alewijk DC, et al. (November 2001). "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells". European Journal of Cancer. 37 (16): 2129–34. doi:10.1016/S0959-8049(01)00259-3. PMID   11597395.
6. "Entrez Gene: TRIM68 tripartite motif-containing 68".
7. Miyajima N, Maruyama S, Bohgaki M, Kano S, Shigemura M, Shinohara N, et al. (May 2008). "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells". Cancer Research. 68 (9): 3486–94. doi: 10.1158/0008-5472.CAN-07-6059 . PMID   18451177.

Further reading

• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Billaut-Mulot O, Cocude C, Kolesnitchenko V, Truong MJ, Chan EK, Hachula E, et al. (September 2001). "SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus". The Journal of Clinical Investigation. 108 (6): 861–9. doi:10.1172/JCI13469. PMC   200937 . PMID   11560955.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.