TRIM55

TRIM55
Identifiers
Aliases	TRIM55 , MURF-2, RNF29, muRF2, tripartite motif containing 55
External IDs	OMIM: 606469; MGI: 3036269; HomoloGene: 13205; GeneCards: TRIM55; OMA:TRIM55 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q13.1 Start 66,126,896 bp [1] End 66,175,485 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 A2 Start 19,698,638 bp [2] End 19,746,585 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle of heart myocardium of left ventricle cardiac muscle tissue of right atrium apex of heart muscle of thigh deltoid muscle tibialis anterior muscle right lobe of liver gastrocnemius muscle biceps brachii Top expressed in heart skeletal muscle tissue quadriceps femoris muscle muscle of thigh esophagus embryo zone of skin lip lens neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding protein binding signal transducer activity metal ion binding identical protein binding Cellular component cytoplasm microtubule intracellular anatomical structure nucleus Biological process signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84675 381485 Ensembl ENSG00000147573 ENSMUSG00000060913 UniProt Q9BYV6 G3X8Y1 RefSeq (mRNA) NM_033058 NM_184085 NM_184086 NM_184087 NM_001081281 RefSeq (protein) NP_149047 NP_908973 NP_908974 NP_908975 NP_001074750 Location (UCSC) Chr 8: 66.13 – 66.18 Mb Chr 3: 19.7 – 19.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene. ^{[5] [6]}

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000147573 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060913 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S (Mar 2001). "Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain". J Mol Biol. 306 (4): 717–26. doi:10.1006/jmbi.2001.4448. PMID   11243782.
6. "Entrez Gene: TRIM55 tripartite motif-containing 55".

Further reading

• McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC   2173255 . PMID   11927605.
• Pizon V, Iakovenko A, Van Der Ven PF, et al. (2003). "Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein". J. Cell Sci. 115 (Pt 23): 4469–82. doi:10.1242/jcs.00131. PMID   12414993. S2CID   16068484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID   15782160. S2CID   6135437.
• Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science. 308 (5728): 1599–603. CiteSeerX   10.1.1.383.9888 . doi:10.1126/science.1110463. PMID   15802564. S2CID   2809403.
• Witt SH, Granzier H, Witt CC, Labeit S (2005). "MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination". J. Mol. Biol. 350 (4): 713–22. doi:10.1016/j.jmb.2005.05.021. PMID   15967462.