TRIM15

TRIM15
Identifiers
Aliases	TRIM15 , RNF93, ZNF178, ZNFB7, tripartite motif containing 15
External IDs	MGI: 1916347 HomoloGene: 23819 GeneCards: TRIM15
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 30,163,206 bp [1] End 30,172,693 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 37,171,583 bp [2] End 37,178,102 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum right lobe of liver gallbladder kidney appendix smooth muscle tissue islet of Langerhans renal cortex bone marrow Top expressed in intestinal villus ileum jejunum duodenum secondary oocyte yolk sac Paneth cell mucous cell of stomach supraoptic nucleus proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding Cellular component intracellular anatomical structure Biological process mesodermal cell fate determination positive regulation of DNA-binding transcription factor activity innate immune response positive regulation of RIG-I signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of type I interferon production negative regulation of intracellular transport of viral material Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89870 69097 Ensembl ENSG00000235960 ENSG00000227147 ENSG00000233599 ENSG00000204610 ENSG00000224145 ENSG00000235905 ENSG00000137384 ENSG00000235259 ENSMUSG00000050747 UniProt Q9C019 n/a RefSeq (mRNA) NM_033229 NM_052812 NM_001024134 NM_001177872 RefSeq (protein) NP_150232 n/a Location (UCSC) Chr 6: 30.16 – 30.17 Mb Chr 17: 37.17 – 37.18 Mb PubMed search [3] [4]
Wikidata
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Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene. ^{[5] [6] [7] [8]}

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms. ^[8]

References

1. ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 GRCh38: Ensembl release 89: ENSG00000235960, ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050747 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC   125245 . PMID   11331580.
6. Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR (Mar 1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection". Am J Hum Genet. 54 (2): 244–51. PMC   1918154 . PMID   8304341.
7. Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM (Feb 1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID   8812418.
8. "Entrez Gene: TRIM15 tripartite motif-containing 15".

Further reading

• Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC   1526686 . PMID   16702430.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Harada H, Harada Y, O'Brien DP, et al. (1999). "HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells". Mol. Cell. Biol. 19 (5): 3808–15. doi:10.1128/MCB.19.5.3808. PMC   84222 . PMID   10207104.