Tanmay A. M. Bharat

Last updated
Tanmay Bharat at the MRC Laboratory of Molecular Biology Bharat Tanmay 2023 CC BY-SA 4.0 MRC LMB.jpg
Tanmay Bharat at the MRC Laboratory of Molecular Biology

Tanmay A. M. Bharat is a programme leader in the Structural Studies Division of the MRC Laboratory of Molecular Biology. [1] He and his group use electron tomography, together with several structural and cell biology methods to study the cell surfaces of bacteria and archaea. His work has increased the understanding of how surface molecules help in the formation of multicellular communities of prokaryotes, examples of which include biofilms and microbiomes. [2] He has been awarded several prizes and fellowships for his work. [3] [4]

Contents

Education

Bharat graduated with a BA in Biological Sciences from the University of Oxford, UK. His studies were supported by a Rhodes Scholarship. He then undertook research at the European Molecular Biology Laboratory in Heidelberg, Germany for his PhD working with John A. G. Briggs. [5] He studied the structure and assembly of pathogenic viruses using cryogenic electron microscopy and tomography. His work on several viral capsid proteins improved understanding of how viruses are assembled within infected cells. [6] [7] [8] [9]

Research

He subsequently joined the MRC Laboratory of Molecular Biology (LMB) in Cambridge to pursue post-doctoral research with Jan Löwe using cryo-EM to study proteins within bacterial cells. [5] [10] [11] [12] After his post-doctoral appointment concluded, he was recruited to the Sir William Dunn School of Pathology, University of Oxford as a Wellcome Trust and Royal Society Sir Henry Dale Fellow. [13] After obtaining tenure at Oxford, he moved back to the LMB as a programme leader in 2022. [14] His research investigates how bacteria and archaea use their surface molecules to form multicellular communities. For instance, during human infections bacteria form biofilms that help them evade antibiotics. The group also use electron tomography. [6]

Scientific publications

Bharat is the author or co-author of over 65 scientific publications. These include:

Awards

Bharat has been awarded many prizes and fellowships. [5] These include a 2018 Vallee Research Scholarship, [5] the 2019 EMBL John Kendrew Award [17] the 2020 Philip Leverhulme Prize for Biological Sciences, [18] the 2021 Eppendorf Award for Young European Investigators, [19] and the 2021 Lister Prize, [20] the 2022 Colworth Medal from the Biochemical Society, [6] the 2023 Fleming Prize from the Microbiology Society, [4] the 2024 Blavatnik Award UK (Life Sciences Finalist) and the 2025 EMBO Gold Medal. [21]

References

  1. ↑ Biology, ©2023 MRC Laboratory of Molecular; Avenue, Francis Crick; Campus, Cambridge Biomedical; CB2 0QH, Cambridge; Uk. 01223 267000. "Tanmay Bharat". MRC Laboratory of Molecular Biology. Retrieved 2023-12-12.{{cite web}}: CS1 maint: numeric names: authors list (link)
  2. ↑ "Tanmay Bharat, PhD | The Vallee Foundation". thevalleefoundation.org. Retrieved 2023-12-12.
  3. ↑ "Tanmay Bharat Prokaryotic cell surfaces". MRC Laboratory of Molecular Biology. UKRI. Retrieved 26 October 2023.
  4. 1 2 "FLEMING PRIZE WINNERS". Microbiology Society. Retrieved 28 April 2020.
  5. 1 2 3 4 "Vallee Scholar Awards: Tanmay Bharat, PhD". The Vallee Foundation. Retrieved 26 October 2023.
  6. 1 2 3 "The Colworth Medal". Biochemical Society. Retrieved 8 September 2022.
  7. ↑ Bharat, Tanmay A. M.; Riches, James D.; Kolesnikova, Larissa; Welsch, Sonja; Krähling, Verena; Davey, Norman; Parsy, Marie-Laure; Becker, Stephan; Briggs, John A. G. (2011-11-15). "Cryo-electron tomography of Marburg virus particles and their morphogenesis within infected cells". PLOS Biology. 9 (11): e1001196. doi: 10.1371/journal.pbio.1001196 . ISSN   1545-7885. PMC   3217011 . PMID   22110401.
  8. ↑ Bharat, Tanmay A. M.; Noda, Takeshi; Riches, James D.; Kraehling, Verena; Kolesnikova, Larissa; Becker, Stephan; Kawaoka, Yoshihiro; Briggs, John A. G. (2012-03-13). "Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography". Proceedings of the National Academy of Sciences of the United States of America. 109 (11): 4275–4280. Bibcode:2012PNAS..109.4275B. doi: 10.1073/pnas.1120453109 . ISSN   1091-6490. PMC   3306676 . PMID   22371572.
  9. ↑ Bharat, Tanmay A. M.; Davey, Norman E.; Ulbrich, Pavel; Riches, James D.; de Marco, Alex; Rumlova, Michaela; Sachse, Carsten; Ruml, Tomas; Briggs, John A. G. (2012-07-19). "Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy". Nature. 487 (7407): 385–389. Bibcode:2012Natur.487..385B. doi:10.1038/nature11169. ISSN   1476-4687. PMID   22722831. S2CID   4423300.
  10. ↑ Kostic, Milka. "MasterClass—Optimizing RELION for cryo-ET by Tanmay Bharat and Sjors Scheres". crosstalk.cell.com. Retrieved 2023-12-07.
  11. ↑ Bharat, Tanmay A. M.; Murshudov, Garib N.; Sachse, Carsten; Löwe, Jan (2015-07-02). "Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles". Nature. 523 (7558): 106–110. Bibcode:2015Natur.523..106B. doi:10.1038/nature14356. ISSN   1476-4687. PMC   4493928 . PMID   25915019.
  12. ↑ van den Ent, Fusinita; Izoré, Thierry; Bharat, Tanmay Am; Johnson, Christopher M.; Löwe, Jan (2014-05-02). "Bacterial actin MreB forms antiparallel double filaments". eLife. 3: e02634. doi: 10.7554/eLife.02634 . ISSN   2050-084X. PMC   4051119 . PMID   24843005.
  13. ↑ "Structural cell biology of bacterial biofilm formation". Wellcome. Retrieved 2023-12-07.
  14. ↑ "Tanmay Bharat CV". www2.mrc-lmb.cam.ac.uk. Retrieved 2023-12-07.
  15. ↑ von Kügelgen, Andriko; Cassidy, C. Keith; van Dorst, Sofie; Pagani, Lennart L.; Batters, Christopher; Ford, Zephyr; Löwe, Jan; Alva, Vikram; Stansfeld, Phillip J.; Bharat, Tanmay A. M. (June 2024). "Membraneless channels sieve cations in ammonia-oxidizing marine archaea". Nature. 630 (8015): 230–236. Bibcode:2024Natur.630..230V. doi:10.1038/s41586-024-07462-5. ISSN   1476-4687. PMC   11153153 . PMID   38811725.
  16. ↑ Böhning, Jan; Graham, Miles; Letham, Suzanne C.; Davis, Luke K.; Schulze, Ulrike; Stansfeld, Phillip J.; Corey, Robin A.; Pearce, Philip; Tarafder, Abul K.; Bharat, Tanmay A. M. (2023-12-19). "Biophysical basis of filamentous phage tactoid-mediated antibiotic tolerance in P. aeruginosa". Nature Communications. 14 (1): 8429. Bibcode:2023NatCo..14.8429B. doi:10.1038/s41467-023-44160-8. ISSN   2041-1723. PMC   10730611 . PMID   38114502.
  17. ↑ "The John Kendrew Award – Alumni relations" . Retrieved 2023-12-21.
  18. ↑ "Philip Leverhulme Prizes 2020 | The Leverhulme Trust". www.leverhulme.ac.uk. Retrieved 2023-12-21.
  19. ↑ "2021 Award Winner - Eppendorf Corporate". corporate.eppendorf.com. Retrieved 2023-12-21.
  20. ↑ "Tanmay Bharat Awarded Lister Institute Research Prize". Sir William Dunn School of Pathology. Retrieved 26 October 2023.
  21. ↑ "EMBO Gold Medal for Tanmay Bharat at the MRC Laboratory of Molecular Biology in Cambridge for structural microbiology work". Cambridge Independent. 6 June 2025. Retrieved 23 June 2025.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.