Tatiana Segura

Tatiana Segura
Alma mater	University of California, Berkeley Northwestern University
Scientific career
Institutions	Duke University Pratt School of Engineering University of California, Los Angeles
Thesis	Engineering substrate-mediated gene delivery : a novel DNA delivery strategy  (2004)

Tatiana Segura is an American biomedical engineer who is a professor at Duke University. Her research considers biomedical engineering solutions to promote cell growth. She was elected Fellow of the American Institute for Medical and Biological Engineering in 2017 and awarded the Acta Biomaterialia Silver Medal in 2021.

Early life and education

Segura earned her undergraduate degree at the University of California, Berkeley. She moved to Northwestern University for her doctoral research, where she used hydrogel scaffolds for non-viral gene delivery with Lonnie Shea. ^[1] Segura moved to the École Polytechnique Fédérale de Lausanne working alongside Jeffrey Hubbell on polymer self-assembly.^{[ citation needed ]}

Research and career

Segura joined University of California, Los Angeles in 2007. She moved to the Duke University Pratt School of Engineering in 2018. ^[2] Segura studies new materials for in situ tissue repair. Her research focuses on the development of hydrogels that can help the body repair damaged or diseased tissue. ^[3] These gels can help the repair by forming a scaffold in the wound that acts like an extracellular matrix, encouraging tissue growth. By integrating an integrin-binding molecule, the blood vessels that form within this new tissue are stronger. ^[3] These hydrogels can harness the body's innate immune response, promoting endogenous (and rapid) tissue repair. ^{[4] [5]} In particular, Segura considers the growth of new neurons and new blood vessels to enable healing in the brain and the skin. New neurons could limit the impact of conditions such as strokes, and in the skin, new blood vessels promote sebaceous gland growth, minimizing scarring. ^{[6] [7] [8]}

Segura created coatings for orthopaedic implants that contained antibiotics, which can eliminate infectious bacteria and transform surgical implants. ^[9]

Awards and honors

• American Society of Gene and Cell Therapy Outstanding Young Investigator Award ^[10]
• American Heart Association National Scientist Development Grant ^[11]
• National Science Foundation CAREER Award ^[12]
• Elected to the College of Fellows at the American Institute for Medical and Biological Engineers ^[13]
• Acta Biomaterialia Silver Medal Award ^{[14] [15]}

Selected publications

• Donald R Griffin; Westbrook M Weaver; Philip O Scumpia; Dino Di Carlo; Tatiana Segura (June 1, 2015). "Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks". Nature Materials . 14 (7): 737–744. doi:10.1038/NMAT4294. ISSN   1476-1122. PMC   4615579 . PMID   26030305. Wikidata   Q36191029.
• Tatiana Segura; Brian C Anderson; Peter H Chung; Rebecca E Webber; Kenneth R Shull; Lonnie D Shea (February 1, 2005). "Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern". Biomaterials . 26 (4): 359–371. doi:10.1016/J.BIOMATERIALS.2004.02.067. ISSN   0142-9612. PMID   15275810. Wikidata   Q34336022.
• Ming Yan; Juanjuan Du; Zhen Gu; et al. (November 22, 2009). "A novel intracellular protein delivery platform based on single-protein nanocapsules". Nature Nanotechnology . 5 (1): 48–53. doi:10.1038/NNANO.2009.341. ISSN   1748-3387. PMID   19935648. Wikidata   Q44697222.

References

1. "Tatiana Segura | Center for Biomolecular and Tissue Engineering". cbte.pratt.duke.edu. Retrieved December 30, 2022.
2. eperkins (October 25, 2020). "Tatiana Segura -". ieeenmdc.org. Retrieved December 30, 2022.
3. "UCLA researchers demonstrate new material that could aid body's cellular repair process". UCLA. Retrieved December 30, 2022.
4. "Bioengineered gel helps repair brain tissue". Physics World. May 23, 2018. Retrieved December 30, 2022.
5. "Wound-healing biomaterials activate immune system for stronger skin". NSF - National Science Foundation. Retrieved December 30, 2022.
6. "New Wound-Healing Biomaterials Reduce Scarring and Promote Tissue Regeneration | UCLA Samueli School Of Engineering" . Retrieved December 30, 2022.
7. says, Jack Travis Nall (November 10, 2020). "New biomaterial significantly reduces scar formation following wounds". News-Medical.net. Retrieved December 30, 2022.
8. University, Duke (November 16, 2020). "Gel heals skin with less scarring and then vanishes". Futurity. Retrieved December 30, 2022.
9. "Breakthrough Discovery Spearheaded by Nicholas Bernthal, M.D., Prevents Infections Related to Orthopedic Implants". www.businesswire.com. October 6, 2021. Retrieved December 30, 2022.
10. "Outstanding New Investigator Awards | ASGCT - American Society of Gene & Cell Therapy | ASGCT - American Society of Gene & Cell Therapy". asgct.org. Retrieved December 30, 2022.
11. "National Scientist Development Grant. American Heart Association. | Scholars@Duke". scholars.duke.edu. Retrieved December 30, 2022.
12. "NSF Award Search: Award # 0747539 - CAREER: Hydrogels for Matrix-Tethered Gene Delivery". www.nsf.gov. Retrieved December 30, 2022.
13. "Tatiana Segura, Ph.D. COF-2186 - AIMBE" . Retrieved December 30, 2022.
14. "Segura Receives the Acta Silver Medal Award". Duke Pratt School of Engineering. October 8, 2020. Retrieved December 30, 2022.
15. "Tatiana Segura, 2021 Acta Biomaterialia Silver Medal Recipient - News - Acta Materialia - Journal - Elsevier". www.journals.elsevier.com. Retrieved December 30, 2022.