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Original author(s) | S. Blair Hedges, Joel Dudley, Sudhir Kumar |
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Initial release | 2006 |
Stable release | v5.0 / 2022 |
Type | Bioinformatics |
License | Freeware |
Website | www |
TimeTree is a free public database developed by S. Blair Hedges and Sudhir Kumar, now at Temple University, for presenting times of divergence in the tree of life. [1] [2] (for the meaning of the word itself, go to timetree). The basic concept has been to produce and present a community consensus of the timetree of life [3] [4] from published studies, and allow easy access to that information on the web or mobile device. [2] The database permits searching for average node times between two species or higher taxa, viewing a timeline from the perspective of a taxon, which shows all divergences back to the origin of life, and building a timetree of a chosen taxon or user-submitted group of taxa. [5] TimeTree has been used in public education to conceptualize the evolution of life, such as in high school settings. [6] [7] [8] David Attenborough's Emmy Award-winning film and television program Rise of Animals used Hedges and Kumar's [3] circular timetree of life, generated from the TimeTree database, as a framework for the production. The timetree was brought to life using animated computer-generated imagery in scenes every 10 minutes during the 2-hour movie. The original development of TimeTree, by Hedges and Kumar, dates to the late 1990s, with initial support from NASA Astrobiology Institute. Since then, it has been supported by additional grants from NASA, and by NSF and NIH. The current version (v5) was released in 2022 and contains data from 4,075 studies and 137,306 species. [5]
TimeTree users can search for the names of two species, such as cat and dog, to obtain the mean and median time estimates for their divergence, in millions of years. The results also show all individual time estimates, from each study, next to a geologic timescale, indicating geologic periods. Different aspects of the Earth's environment are shown next to the timescale for comparison, including Earth impacts, solar luminosity, carbon dioxide levels, and oxygen levels. Separately, a table lists the time estimates, downloadable as a spreadsheet, from each study along with references and links to the abstracts of the original articles. Users can download the original study data as Newick-formatted timetrees for further research. In the timeline search, users type the name of a taxon, and all divergences back to the origin of life are show with their taxon names, in a vertical ladder-like figure. Timepanels of Earth's environment also are shown next to the geological timescale, as in all three search options. The third search option, timetree search, involves building a timetree by either specifying a taxon (group) name or uploading a list of species or other taxa. After specifying a group name, the user can choose which taxonomic level they prefer to view. For example, with a family group name, either a species-level or genus-level timetree can be selected. Then, the timetree is show and can be output as a Newick file or image for publication. Times on the tree can be explored by clicking on nodes, and obtaining tables of data pertaining to the node. The database also allows search of timetree articles by author name. The entire open-access book Timetree of Life [3] is presented on the site.
A phylogenetic tree is a branching diagram or a tree showing the evolutionary relationships among various biological species or other entities based upon similarities and differences in their physical or genetic characteristics. All life on Earth is part of a single phylogenetic tree, indicating common ancestry.
The molecular clock is a figurative term for a technique that uses the mutation rate of biomolecules to deduce the time in prehistory when two or more life forms diverged. The biomolecular data used for such calculations are usually nucleotide sequences for DNA, RNA, or amino acid sequences for proteins. The benchmarks for determining the mutation rate are often fossil or archaeological dates. The molecular clock was first tested in 1962 on the hemoglobin protein variants of various animals, and is commonly used in molecular evolution to estimate times of speciation or radiation. It is sometimes called a gene clock or an evolutionary clock.
The Archonta are a now-abandoned group of mammals, considered a superorder in some classifications, which consists of these orders:
A phylogenetic network is any graph used to visualize evolutionary relationships between nucleotide sequences, genes, chromosomes, genomes, or species. They are employed when reticulation events such as hybridization, horizontal gene transfer, recombination, or gene duplication and loss are believed to be involved. They differ from phylogenetic trees by the explicit modeling of richly linked networks, by means of the addition of hybrid nodes instead of only tree nodes. Phylogenetic trees are a subset of phylogenetic networks. Phylogenetic networks can be inferred and visualised with software such as SplitsTree, the R-package, phangorn, and, more recently, Dendroscope. A standard format for representing phylogenetic networks is a variant of Newick format which is extended to support networks as well as trees.
Computational phylogenetics is the application of computational algorithms, methods, and programs to phylogenetic analyses. The goal is to assemble a phylogenetic tree representing a hypothesis about the evolutionary ancestry of a set of genes, species, or other taxa. For example, these techniques have been used to explore the family tree of hominid species and the relationships between specific genes shared by many types of organisms.
PHYLogeny Inference Package (PHYLIP) is a free computational phylogenetics package of programs for inferring evolutionary trees (phylogenies). It consists of 65 portable programs, i.e., the source code is written in the programming language C. As of version 3.696, it is licensed as open-source software; versions 3.695 and older were proprietary software freeware. Releases occur as source code, and as precompiled executables for many operating systems including Windows, Mac OS 8, Mac OS 9, OS X, Linux ; and FreeBSD from FreeBSD.org. Full documentation is written for all the programs in the package and is included therein. The programs in the phylip package were written by Professor Joseph Felsenstein, of the Department of Genome Sciences and the Department of Biology, University of Washington, Seattle.
The tree of life or universal tree of life is a metaphor, model and research tool used to explore the evolution of life and describe the relationships between organisms, both living and extinct, as described in a famous passage in Charles Darwin's On the Origin of Species (1859).
The affinities of all the beings of the same class have sometimes been represented by a great tree. I believe this simile largely speaks the truth.
Eusporangiate ferns are vascular spore plants, whose sporangia arise from several epidermal cells and not from a single cell as in leptosporangiate ferns. Typically these ferns have reduced root systems and sporangia that produce large amounts of spores
The Pythonoidea, also known as pythonoid snakes, are a superfamily of snakes that contains pythons and other closely related python-like snakes. As of 2022, Pythonoidea contains 39 species, including the eponymous genus Python and 10 other genera of pythons, all in the family Pythonidae, as well as two lesser-known families, Loxocemidae and Xenopeltidae.
Terrabacteria is a taxon containing approximately two-thirds of prokaryote species, including those in the gram positive phyla as well as the phyla "Cyanobacteria", Chloroflexota, and Deinococcota.
Polypodiineae is a suborder of ferns in the order Polypodiales. It is equivalent to the clade eupolypods I in earlier systems, and to the very broadly defined family Polypodiaceae in the classification of Christenhusz & Chase (2014). It probably diverged from the suborder Aspleniineae during the mid-Cretaceous. The divergence is supported by both molecular data and an often overlooked morphological characteristic which lies in the vasculature of the petiole. Most species that make up the suborder have three vascular bundles. The only exceptions are the grammitid ferns which have one, and the genus Hypodematium which has two. This differs from eupolypods II which mostly have two vascular bundles.
A patrocladogram is a cladistic branching pattern that has been precisely modified by use of patristic distances ; a type of phylogram. The patristic distance is defined as, "the number of apomorphic step changes separating two taxa on a cladogram," and is used exclusively to determine the amount of divergence of a characteristic from a common ancestor. This means that cladistic and patristic distances are combined to construct a new tree using various phenetic algorithms. The purpose of the patrocladogram in biological classification is to form a hypothesis about which evolutionary processes are actually involved before making a taxonomic decision. Patrocladograms are based on biostatistics that include but are not limited to: parsimony, distance matrix, likelihood methods, and Bayesian probability. Some examples of genomically related data that can be used as inputs for these methods are: molecular sequences, whole genome sequences, gene frequencies, restriction sites, distance matrices, unique characters, mutations such as SNPs, and mitochondrial genome data.
T-REX is a freely available web server, developed at the department of Computer Science of the Université du Québec à Montréal, dedicated to the inference, validation and visualization of phylogenetic trees and phylogenetic networks. The T-REX web server allows the users to perform several popular methods of phylogenetic analysis as well as some new phylogenetic applications for inferring, drawing and validating phylogenetic trees and networks.
Hydrobacteria is a taxon containing approximately one-third of prokaryote species, mostly gram-negative bacteria and their relatives. It was found to be the closest relative of an even larger group of Bacteria, Terrabacteria, which are mostly gram positive bacteria. The name Hydrobacteria refers to the moist environment inferred for the common ancestor of those species. In contrast, species of Terrabacteria possess adaptations for life on land.
Stephen Blair Hedges is Laura H. Carnell Professor of Science and director of the Center for Biodiversity at Temple University where he researches the tree of life and leads conservation efforts in Haiti and elsewhere. He co-founded Haiti National Trust.
A timetree is a phylogenetic tree scaled to time. It shows the evolutionary relationships of a group of organisms in a temporal framework. For the database by the same name, go to TimeTree.
The Booidea, also known as booid snakes, are a superfamily of snakes that contains boas and other closely related boa-like snakes. As of 2017, Booidea contains 61 species, including the eponymous neotropical Boa constrictor, anacondas, and smaller tree and rainbow boas as well as several genera of booid snakes from various locations around the world: bevel-nosed boas or keel-scaled boas (Candoia) from New Guinea and Melanesia, Old World sand boas (Eryx) from Northeast Africa, the Middle East, and Southwest Asia, rubber boas (Charina) and rosy boas (Lichanura) from North America, neotropical dwarf boas (Ungaliophis) and the Oaxacan dwarf boa (Exiliboa) from Central America, Madagascan boas or Malagasy boas from Madagascar, and the Calabar python (Calabaria) from tropical West-Central Africa.
The Uropeltoidea, also known as uropeltoid snakes, are a superfamily of snakes that contains uropeltids and Asian pipesnakes.
The Amerophidia, also known as amerophidian snakes, are a superfamily of snakes that contains two families: Aniliidae and the boa-like Tropidophiidae.
Afrophidia is a clade of alethinophidian snakes comprising the groups Henophidia and Caenophidia, essentially making up the snakes people commonly associate with. The name refers to the deep split between Afrophidia and their sister taxon, Amerophidia, which originated in South American origin, and the afrophidians was recently hypothesized to represent a vicariant event of the breakup of Gondwanan South America and Africa.
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