Timeline of the opioid epidemic

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The timeline of the opioid epidemic includes selected events related to the origins of Stamford, Connecticut-based Purdue Pharma, the Sackler family, the development and marketing of oxycodone, selected FDA activities related to the abuse and misuse of opioids, the recognition of the opioid epidemic, the social impact of the crisis, lawsuits against Purdue and the Sackler family.

Fentanyl. 2 mg (white powder to the right) is a lethal dose in most people. US penny is 19 mm (0.75 in) wide. Fentanyl. 2 mg. A lethal dose in most people.jpg
Fentanyl. 2 mg (white powder to the right) is a lethal dose in most people. US penny is 19 mm (0.75 in) wide.

Notes

  1. The lawyer for Suffolk County, Paul Hanly, is "also a lead attorney in a huge civil action playing out in federal court in Cleveland, Ohio, involving opioid manufacturers and distributors".
  2. According to the February 2018 article in The Guardian , three of Mortimer David Sackler's children, Ilene Sackler Lefcourt, Kathe Sackler, and Mortimer David Alfons (Mortimer) Sackler are currently on Purdue Pharma's Board of Directors along with Theresa Sackler, the third wife of Mortimer David Sackler. Current Purdue Board of Directors also include Raymond Sackler's sons, Jonathan Sackler, Richard Stephen Sackler, former Purdue CEO and current director, and his son David Sackler. Richard wife, Beverly Sackler, is a former Purdue director.

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References

  1. 1 2 3 4 5 "Timeline of Selected FDA Activities and Significant Events Addressing Opioid Misuse and Abuse". Food and Drug Administration (FDA). 2018. p. 34. Archived from the original on 21 August 2020. Retrieved 17 July 2019.
  2. 1 2 3 4 Weber, Bruce (31 March 2010). "Mortimer D. Sackler, Arts Patron, Dies at 93". The New York Times. Retrieved 30 December 2017.
  3. Dalyell, Tam (31 March 2010). "Doctor Mortimer Sackler: Philanthropist who repaid many times over the debt he felt he owed Britain" . The Independent. Obituary. Archived from the original on 21 June 2022. Retrieved 2 January 2019. Member, Chancellor's Court of Benefactors, Oxford University from 1993; PhD Tel Aviv 1980; Officier, Légion d'Honneur 1997; honorary KBE 1999; Honorary Fellow, King's College, London 2001
  4. "Dr Mortimer Sackler". The Telegraph. 27 April 2010. ISSN   0307-1235 . Retrieved 2 January 2019.
  5. "The University of Glasgow Story: Mortimer Sackler". Archived from the original on 9 December 2018. Retrieved 28 August 2018.
  6. "Mortimer Sackler dies at 93; arts patron was co-owner of Purdue Pharma", Los Angeles Times, 8 March 2014, retrieved 17 July 2019
  7. Glazek, Christopher (16 October 2017). "The Secretive Family Making Billions From the Opioid Crisis". Esquire. Retrieved 2 January 2018.
  8. Keefe The New Yorker October 23, 2017
  9. Davison, Phil (24 April 2010). "Drugs mogul with a vast philanthropic legacy". The Financial Times. Retrieved 30 December 2017.
  10. 1 2 3 4 5 6 Van Zee, Art (February 2009). "The Promotion and Marketing of OxyContin: Commercial Triumph, Public Health Tragedy". American Journal of Public Health. 99 (2): 221–227. doi:10.2105/AJPH.2007.131714. PMC   2622774 . PMID   18799767.
  11. New Drug Application to FDA for OxyContin, Pharmacology Review: 'Abuse Liability of Oxycodone.'. Purdue Pharma (Report). Stamford, CN. 1995.
  12. Sunshine, Abraham; Olson, Nancy Z.; Colon, Ariel; Rivera, Juana; Kaiko, Robert F.; Fitzmartin, Ronald D.; Reder, Robert F.; Goldenheim, Paul D. (July 1996). "Analgesic Efficacy of Controlled-Release Oxycodone in Postoperative Pain". Journal of Clinical Pharmacology. 36 (7): 595–603. doi:10.1002/j.1552-4604.1996.tb04223.x. PMID   8844441. S2CID   35076787. Duration of pain relief showed that the 10-, 20-, and 30-mg doses of CR oxycodone had durations of action of 10 to 12 hours compared with IR oxycodone and oxycodone plus APAP (both approximately 7 hours). Typical adverse events, particularly somnolence, occurred in all active treatment groups. Treatment with CR oxycodone was safe and effective in this study, and its characteristics will be beneficial in the treatment of pain.
  13. 1 2 3 Meier, Barry (8 June 2018). "Every Time I Thought the Purdue Pharma OxyContin Story Was Over, I Was Wrong: Not only would a previously undisclosed prosecution report surface more than a decade after it was written, but as fate would have it, I would be in it". New York Times. Retrieved 21 November 2018.
  14. 1 2 "Origins of an Epidemic: Purdue Pharma Knew Its Opioids Were Widely Abused". The New York Times. 29 May 2018. Retrieved 30 January 2019.
  15. 1 2 3 4 5 Frehse, Rob; Marco, Tony (30 January 2019). "Opioid maker Purdue Pharma fights to prevent documents involving Sackler family from going public". CNN. Retrieved 30 January 2019.
  16. "Dispelling the Myths About Opioids", Purdue Pharma, Brochure for physicians, Stamford, CN, 1998
  17. Fentanyl. Image 4 of 17. US DEA (Drug Enforcement Administration). See archive with caption: "photo illustration of 2 milligrams of fentanyl, a lethal dose in most people".
  18. 1 2 Meier, Barry (17 October 2003). Pain Killer: A Wonder Drug's Trail of Addiction and Death . Rodale Books. pp.  333. ISBN   9781579546380.
  19. 1 2 Kenneally, Christine (4 January 2004). "Pain Killer". New York Times. Books in Brief: Nonfiction. Retrieved 21 November 2018.
  20. "Testimony of Paul Goldenheim: OxyContin: balancing risks and benefits". Hearing of the Committee on Health, Education, Labor, and Pensions, United States Senate. 12 February 2002.
  21. Biancofiore, Giandomenico Luigi (1 September 2006). "Oxycodone controlled release in cancer pain management" (PDF). Therapeutics and Clinical Risk Management. 2 (3): 229–34. doi: 10.2147/tcrm.2006.2.3.229 . PMC   1936259 . PMID   18360598 . Retrieved 30 January 2019.
  22. Meier, Barry (19 June 2007). "Big Part of OxyContin Profit Was Consumed by Penalties". The New York Times .
  23. "Kentucky sues makers of OxyContin - USATODAY.com". usatoday30.usatoday.com. Retrieved 22 October 2017.
  24. "Kentucky settles lawsuit with OxyContin maker for $24 million". www.cbsnews.com. 23 December 2015. Retrieved 2 May 2016.
  25. "Origins of an epidemic: Purdue Pharma knew opioids were widely abused". 25 May 2018. Retrieved 30 January 2019.
  26. 1 2 3 Stempel, Jonathan (14 August 2018). "New York sues OxyContin maker Purdue Pharma over opioids". Reuters. Retrieved 21 November 2018.
  27. 1 2 3 Meier, Barry (21 July 2007). "3 Executives Spared Prison in OxyContin Case". New York Times. Retrieved 21 November 2018.
  28. Sue Lindsey, (May 11, 2007) OxyContin Maker, Execs Guilty of Deceit USA Today reproducing and Associated Press report
  29. Barry Meier, (May 11, 2007) "In Guilty Plea, OxyContin Maker to Pay $600 Million", New York Times
  30. 1 2 3 4 Lopez, German (12 February 2018). "The maker of OxyContin will finally stop marketing the addictive opioid to doctors: The move comes after the company helped cause an ongoing drug overdose crisis that has killed hundreds of thousands". VOX. Retrieved 21 November 2018. Purdue's decision to stop marketing OxyContin comes at a convenient time for the company. Purdue, along with other opioid companies, has over the past several years faced an increasing number of lawsuits from cities, counties, and states blaming the drug manufacturers for irresponsibly fostering the current overdose crisis. At the same time, the company's profits from OxyContin, as well as opioid prescriptions in general, have recently dropped — OxyContin generated $1.8 billion in 2017, down from $2.8 billion in 2012, Bloomberg reported.
  31. Kolodny, Andrew; Courtwright, David T.; Hwang, Catherine S.; Kreiner, Peter; Eadie, John L.; Clark, Thomas W.; Alexander, G. Caleb (12 January 2015). "The Prescription Opioid and Heroin Crisis: A Public Health Approach to an Epidemic of Addiction". Annual Review of Public Health. 36: 559–74. doi: 10.1146/annurev-publhealth-031914-122957 . PMID   25581144.
  32. 1 2 "attorney general of the state of new york in the matter of purdue pharma l.p. assurance no.: 15-151 assurance of discontinuance under executive law section 63, subdivision 15" (PDF). Office of the Attorney General (OAG) State of New York. Retrieved 21 November 2018.
  33. "In 2015, Purdue entered into an Assurance of Discontinuance with the New York Attorney General", Office of the Governor of New York, 14 August 2018
  34. 1 2 Harriet, Ryan (27 May 2016). "Senator calls for investigation of Purdue Pharma following Times story on OxyContin". Los Angeles Times . Retrieved 21 November 2018.
  35. Basler, Cassandra (25 October 2018). "Suffolk County Sues Purdue Pharma Family Over Opioids". NPR via WSHU. Retrieved 30 January 2019.
  36. Glazek, Christopher (16 October 2017). "The Secretive Family Making Billions From the Opioid Crisis". Esquire. Retrieved 24 November 2020.
  37. Harriet Ryan (19 January 2017), "City devastated by OxyContin use sues Purdue Pharma, claims drugmaker put profits over citizens' welfare", The Los Angeles Times
  38. Scott North (20 February 2017), "Everett's suit against OxyContin maker moves to federal court", Everett Herald
  39. "U.S. City Sues OxyContin Maker For Contributing To Opioid Crisis", Morning Edition , NPR, 3 February 2017
  40. Bellon, Tina (15 May 2018). "U.S. state lawsuits against Purdue Pharma over opioid epidemic mount". Reuters. Retrieved 5 June 2018.
  41. Moritz, John C. "6 states sue maker of OxyContin as they battle expenses, human costs of opioid crisis". USA TODAY. Corpus Christi (Texas) Caller Times. Retrieved 5 June 2018. From Purdue Pharma article
  42. 1 2 3 4 5 6 7 8 9 Walters, Joanna (13 February 2018). "Meet the Sacklers: the family feuding over blame for the opioid crisis". The Guardian. ISSN   0261-3077 . Retrieved 2 January 2019.
  43. 1 2 Zezima, Katie; Bernstein, Lenny (15 January 2019). "Hammer on the abusers': Mass. attorney general alleges Purdue". The Washington Post. Retrieved 30 January 2019.
  44. Siemaszko, Corky (16 June 2018). "They're the first family of pharma. And now they're being sued". NBC News. Retrieved 2 February 2019.
  45. Cortellessa, Eric (21 November 2018). "Sackler family faces possible criminal charges for role in opioid crisis: New York's Suffolk County sues Jewish multi-billionaire owners of Purdue Pharma, the maker of OxyContin; Connecticut and NY considering pressing charges". Washington, DC: Times of Israel . Retrieved 21 November 2018.
  46. State of Connecticut v Purdue (PDF), 20 December 2018, p. 30, retrieved 2 January 2019, State of Connecticut, : Superior court plaintiff, : : judicial district : of Hartford v. Purdue Pharma L.P., Purdue Pharma Inc., Richard Sackler, Theresa Sackler, Kathe Sackler, Jonathan Sackler, Mortimer D.A. Sackler, Beverly Sackler, David Sackler, Ilene Sackler Lefcourt, Frank Peter Boer, Paulo Costa, Cecil Pickett, Ralph Snyderman, Judy Lewent, John Stewart and Mark Timney
  47. 1 2 "Family behind OxyContin maker engineered opioid crisis, Massachusetts AG says". CBS News. 24 January 2019. Retrieved 2 February 2019.
  48. Meier, Barry (1 February 2019). "Sackler Scion's Email Reveals Push for High-Dose OxyContin, New Lawsuit Disclosures Claim". The New York Times. ISSN   0362-4331 . Retrieved 2 February 2019.
  49. Meier, Barry (1 February 2019). "Sackler Scion's Email Reveals Push for High-Dose OxyContin, New Lawsuit Disclosures Claim". The New York Times. ISSN   0362-4331 . Retrieved 2 February 2019.
  50. Forsythe, Michael; Bogdanich, Walt (2 February 2019). "McKinsey Advised Purdue Pharma How to 'Turbocharge' Opioid Sales, Lawsuit Says". The New York Times. ISSN   0362-4331 . Retrieved 2 February 2019.
  51. Walters, Joanna (31 January 2019). "Opioids: Boston trial opens what could be year of reckoning for executives". The Guardian. ISSN   0261-3077 . Retrieved 2 February 2019.
  52. Fernandez, Marisa. "DOJ alleges Walmart's lack of oversight in pharmacies helped fuel opioid crisis". Axios.
  53. Hosenball, Mark (23 December 2020). "U.S. sues Walmart saying pharmacies fueled opioid crisis, retailer rejects allegations". Archived from the original on 22 December 2020 via uk.reuters.com.
  54. Stat web page https://www.statnews.com/pharmalot/2021/02/04/mckinsey-purdue-opioids-settlement/ 4 Feb. 2021; also New York Times, 3 Feb. 2021, https://www.nytimes.com/2021/02/03/business/mckinsey-opioids-settlement.html .