Timothy Buie

Last updated
Timothy M. Buie
Medical career
InstitutionsBoston Children’s Hospital
Harvard Medical School

Timothy M. Buie is a pediatric gastroenterologist at Boston Children’s Hospital. Buie joined Harvard Medical School in 1998 after previously practicing at Pediatric Gastroenterology Associates for eight years. [1] He was also the director of Gastrointestinal and Nutritional Services at MGH's Lurie Center for Autism. [2] He is well known for his research pertaining to the possible connection between autism and gastrointestinal disorders, and has told the Interagency Autism Coordinating Committee that over half of autistic children experience gastrointestinal symptoms, [2] whereas he stated that this was the case for "between 50 and 70%" of children with autism in an interview with ABC News. [3] He has also said that a subset of autistic children (though not the majority) may benefit from gluten-free, casein-free diets, and that more research is needed into this area. [4] [5] [6] Buie was honored as "Professional of the Year" by the Autism Society of America in 2009. [7]



Buie received his bachelor's degree in biology in 1984 and his MD in 1988, both from the University of Missouri at Kansas City. [8] He then completed his fellowship at Yale University and his residency at Bridgeport Hospital. [9]


Buie has published several papers regarding gastrointestinal problems in autistic children. These studies have usually concluded that gastrointestinal problems are not any more common in autistic children than they are in neurotypical children. [10] [11] [12] Buie also co-authored a paper with Mady Hornig which provided further evidence against a link between the MMR vaccine and autism. [13]

Views on autism

With regard to the cause of autism, Buie said, in an interview with PBS NewsHour, that "there are over 100 suspect genes that are associated with a higher frequency of autism. So there is clearly an underlying genetic predisposition to this condition in many children. But the possibility that there is some environmental factor or some extrinsic factor that affects those children, I think, still needs to sit on the table." He also said that scientific studies investigating the potential link between the MMR vaccine and autism have not supported the hypothesis of a link between the two. [6]

Related Research Articles

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Mady Hornig is an American psychiatrist and an associate professor of epidemiology at Columbia University's Mailman School of Public Health. A physician-scientist, her research involves clinical, epidemiological, and animal model research on autism and related neurodevelopmental conditions. She directs the clinical core of an international investigation of the role of Borna disease virus in human mental illness and participates as a key investigator for the Autism Birth Cohort (ABC) project, a large prospective epidemiological study, based in Norway, that is identifying how genes and timing interact with environmental agents preceding the onset of autism spectrum diagnoses. In 2006, she was appointed as guest professor at the school of basic medical science of Beijing University in Beijing, China.

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  1. Timothy M. Buie Massachusetts General Hospital
  2. 1 2 "IACC Gains Troubling Insights Into GI Disorders". Autism Speaks website. 10 July 2013. Retrieved 30 January 2014.
  3. "Gastrointestinal Disorders and Autism?". ABC News . 25 August 2008. Retrieved 30 January 2014.
  4. Dominus, Susan (20 April 2011). "The Crash and Burn of an Autism Guru". New York Times . Retrieved 30 January 2014. Timothy Buie, a pediatric gastroenterologist at Harvard Medical School, felt that the press ignored other key implications in their findings: that there might be a subsection of autistic patients who would benefit from dietary interventions and that the role of the immune system in gastrointestinal dysfunction in children with autism "warrants additional investigation."
  5. "Special diets unnecessary for autistic children". NBC News . 28 January 2010. Retrieved 30 January 2014.
  6. 1 2 Macneil, Robert (18 April 2011). "Autism Now: Dr. Timothy Buie Extended Interview". PBS NewsHour . Retrieved 30 January 2014.
  7. "In General Awards and Honors". Massachusetts General Hospital. 21 August 2009. Retrieved 30 January 2014.
  8. Dr. Timothy Buie to present at Bloch Executive Hall Archived 2014-01-30 at archive.today
  9. Timothy M. Buie, Newton-Wellesley Hospital
  10. Buie, T.; Campbell, D. B.; Fuchs Gj, G. J.; Furuta, G. T.; Levy, J.; Vandewater, J.; Whitaker, A. H.; Atkins, D.; Bauman, M. L.; Beaudet, A. L.; Carr, E. G.; Gershon, M. D.; Hyman, S. L.; Jirapinyo, P.; Jyonouchi, H.; Kooros, K.; Kushak, R.; Levitt, P.; Levy, S. E.; Lewis, J. D.; Murray, K. F.; Natowicz, M. R.; Sabra, A.; Wershil, B. K.; Weston, S. C.; Zeltzer, L.; Winter, H. (2010). "Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals with ASDs: A Consensus Report". Pediatrics. 125: S1–18. CiteSeerX . doi:10.1542/peds.2009-1878C. PMID   20048083. S2CID   318955.
  11. Buie, T.; Fuchs Gj, G. J.; Furuta, G. T.; Kooros, K.; Levy, J.; Lewis, J. D.; Wershil, B. K.; Winter, H. (2010). "Recommendations for Evaluation and Treatment of Common Gastrointestinal Problems in Children with ASDs". Pediatrics. 125: S19–S29. doi: 10.1542/peds.2009-1878D . PMID   20048084.
  12. "Autism 'leaky gut' rejected". CBC.ca . 4 January 2010. Retrieved 30 January 2014.
  13. Hornig, M.; Briese, T.; Buie, T.; Bauman, M. L.; Lauwers, G.; Siemetzki, U.; Hummel, K.; Rota, P. A.; Bellini, W. J.; O'Leary, J. J.; Sheils, O.; Alden, E.; Pickering, L.; Lipkin, W. I. (2008). Cookson, Mark R (ed.). "Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study". PLOS ONE. 3 (9): e3140. Bibcode:2008PLoSO...3.3140H. doi: 10.1371/journal.pone.0003140 . PMC   2526159 . PMID   18769550.