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Tissuemed Ltd.
Industry Medical Devices
Headquarters Leeds, West Yorkshire, U.K.
ProductsTissuePatch product family of surgical sealant films
Website www.tissuemed.com

Tissuemed is a medical device developer and manufacturer based in Leeds, UK.

The company was founded in 1985 and developed the first tissue heart valve (derived from pigs) to receive regulatory approval (CE mark) in Europe. This business was divested in 1999, [1] and the heart values are currently sold by Vascutek, a Terumo company, under the Aspire brand. [2] [3] Thereafter, Tissuemed focused on the development of innovative tissue adhesives for internal surgical use, including a light activated tissue sealant to prevent blood loss during vascular anastomosis, the TissueBond system. [4] [5]

More recently in 2007, Tissuemed launched TissuePatch, a range of surgical sealant films for the prevention of leaks during surgery, including thoracic, general and neurosurgery. [6] [7]

These products incorporate a unique synthetic bioadhesive that forms a covalent bond with tissue proteins, enabling adhesion to internal organs and achieving a sealing effect. In June 2016, Tissuemed won approval from China’s FDA for its TissuePatch surgical sealant. [8]

The company was acquired by Becton Dickinson in 2021. [9]

Related Research Articles

<span class="mw-page-title-main">Neurosurgery</span> Medical specialty of disorders which affect any portion of the nervous system

Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty concerned with the surgical treatment of disorders which affect any portion of the nervous system including the brain, spinal cord and peripheral nervous system.

<span class="mw-page-title-main">Aneurysm</span> Bulge in the wall of a blood vessel

An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak spot on a blood vessel wall. Aneurysms may be a result of a hereditary condition or an acquired disease. Aneurysms can also be a nidus for clot formation (thrombosis) and embolization. As an aneurysm increases in size, the risk of rupture, which leads to uncontrolled bleeding, increases. Although they may occur in any blood vessel, particularly lethal examples include aneurysms of the Circle of Willis in the brain, aortic aneurysms affecting the thoracic aorta, and abdominal aortic aneurysms. Aneurysms can arise in the heart itself following a heart attack, including both ventricular and atrial septal aneurysms. There are congenital atrial septal aneurysms, a rare heart defect.

<span class="mw-page-title-main">Vascular surgery</span> Medical specialty, operative procedures for the treatment of vascular disorders

Vascular surgery is a surgical subspecialty in which vascular diseases involving the arteries, veins, or lymphatic vessels, are managed by medical therapy, minimally-invasive catheter procedures and surgical reconstruction. The specialty evolved from general and cardiovascular surgery where it refined the management of just the vessels, no longer treating the heart or other organs. Modern vascular surgery includes open surgery techniques, endovascular techniques and medical management of vascular diseases - unlike the parent specialities. The vascular surgeon is trained in the diagnosis and management of diseases affecting all parts of the vascular system excluding the coronaries and intracranial vasculature. Vascular surgeons also are called to assist other physicians to carry out surgery near vessels, or to salvage vascular injuries that include hemorrhage control, dissection, occlusion or simply for safe exposure of vascular structures.

<span class="mw-page-title-main">Arachnoiditis</span> Inflammation of the arachnoid mater

Arachnoiditis is an inflammatory condition of the arachnoid mater or 'arachnoid', one of the membranes known as meninges that surround and protect the nerves of the central nervous system, including the brain and spinal cord. The arachnoid can become inflamed because of adverse reactions to chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, complications from spinal surgery or other invasive spinal procedures, or the accidental intrathecal injection of steroids intended for the epidural space. Inflammation can sometimes lead to the formation of scar tissue and adhesion that can make the spinal nerves "stick" together, a condition where such tissue develops in and between the leptomeninges. The condition is extremely painful, especially when progressing to adhesive arachnoiditis. Another form of the condition is arachnoiditis ossificans, in which the arachnoid becomes ossified, or turns to bone, and is thought to be a late-stage complication of the adhesive form of arachnoiditis.

<span class="mw-page-title-main">Microsurgery</span>

Microsurgery is a general term for surgery requiring an operating microscope. The most obvious developments have been procedures developed to allow anastomosis of successively smaller blood vessels and nerves which have allowed transfer of tissue from one part of the body to another and re-attachment of severed parts. Microsurgical techniques are utilized by several specialties today, such as general surgery, ophthalmology, orthopedic surgery, gynecological surgery, otolaryngology, neurosurgery, oral and maxillofacial surgery, plastic surgery, podiatric surgery and pediatric surgery.

<span class="mw-page-title-main">Hemangiopericytoma</span> Medical condition

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<span class="mw-page-title-main">Surgical planning</span>

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<span class="mw-page-title-main">Cerebrospinal fluid leak</span> Medical condition

A cerebrospinal fluid leak is a medical condition where the cerebrospinal fluid (CSF) surrounding the brain or spinal cord leaks out of one or more holes or tears in the dura mater. A cerebrospinal fluid leak can be either cranial or spinal, and these are two different disorders. A spinal CSF leak can be caused by one or more meningeal diverticula or CSF-venous fistulas not associated with an epidural leak.

A fibrin scaffold is a network of protein that holds together and supports a variety of living tissues. It is produced naturally by the body after injury, but also can be engineered as a tissue substitute to speed healing. The scaffold consists of naturally occurring biomaterials composed of a cross-linked fibrin network and has a broad use in biomedical applications.

<span class="mw-page-title-main">Tarlov cyst</span> Medical condition

Tarlov cysts, are type II innervated meningeal cysts, cerebrospinal-fluid-filled (CSF) sacs most frequently located in the spinal canal of the sacral region of the spinal cord (S1–S5) and much less often in the cervical, thoracic or lumbar spine. They can be distinguished from other meningeal cysts by their nerve-fiber-filled walls. Tarlov cysts are defined as cysts formed within the nerve-root sheath at the dorsal root ganglion. The etiology of these cysts is not well understood; some current theories explaining this phenomenon have not yet been tested or challenged but include increased pressure in CSF, filling of congenital cysts with one-way valves, inflammation in response to trauma and disease. They are named for American neurosurgeon Isadore Tarlov, who described them in 1938.

Endoscopic vessel harvesting (EVH) is a surgical technique that may be used in conjunction with coronary artery bypass surgery. For patients with coronary artery disease, a physician may recommend a bypass to reroute blood around blocked arteries to restore and improve blood flow and oxygen to the heart. To create the bypass graft, a surgeon will remove or "harvest" healthy blood vessels from another part of the body, often from the patient's leg or arm. This vessel becomes a graft, with one end attaching to a blood source above and the other end below the blocked area, creating a "conduit" channel or new blood flow connection across the heart.

Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. Using organelles, dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers. Furthermore, these dermal fibroblasts produce the protein molecules including laminin and fibronectin which comprise the extracellular matrix. By creating the extracellular matrix between the dermis and epidermis, fibroblasts allow the epithelial cells of the epidermis to affix the matrix, thereby allowing the epidermal cells to effectively join together to form the top layer of the skin.

<span class="mw-page-title-main">Hybrid operating room</span> Type of surgical theatre

A hybrid operating room is a surgical theatre that is equipped with advanced medical imaging devices such as fixed C-Arms, X-ray computed tomography (CT) scanners or magnetic resonance imaging (MRI) scanners. These imaging devices enable minimally-invasive surgery. Minimally-invasive surgery is intended to be less traumatic for the patient and minimize incisions on the patient and perform surgery procedure through one or several small cuts.

<span class="mw-page-title-main">Surgical sealant film</span>

A surgical sealant film is an implantable medical device used during surgery. It is a preformed flexible patch that is applied to supplement sutures and surgical staples to seal tissues and prevent leaks of fluid and air.

The Dextroscope is a medical equipment system that creates a virtual reality (VR) environment in which surgeons can plan neurosurgical and other surgical procedures.

Postoperative wounds are those wounds acquired during surgical procedures. Postoperative wound healing occurs after surgery and normally follows distinct bodily reactions: the inflammatory response, the proliferation of cells and tissues that initiate healing, and the final remodeling. Postoperative wounds are different from other wounds in that they are anticipated and treatment is usually standardized depending on the type of surgery performed. Since the wounds are 'predicted' actions can be taken beforehand and after surgery that can reduce complications and promote healing.

Volume Interactions Pte Ltd was a company that pioneered in the 1990s the use Virtual Reality technology in surgery planning. The company created and marketed the Dextroscope, the first commercial surgical planning system that used virtual reality principles going beyond the mouse and keyboard. The Dextroscope introduced a variation of Virtual Reality technology that didn't use Head-Mounted display that provided a natural and comfortable interface to work with multi-modality 3D medical images for long periods of time. This environment was applied to the planning of patient-specific surgical approaches for several clinical disciplines, including neurosurgery, Ear-Nose-Throat, and liver surgery. The Dextroscope received world-wide attention by being involved in the planning of several craniopagus twin separations, most notably the Zambian twins (1997) and the German twins (2004) at Johns Hopkins Hospital led by Dr Benjamin Carson, and the Nepali twins separation at the Singapore General Hospital in 2001.

William D. Spotnitz is a cardiothoracic surgeon and medical researcher who has made significant contributions to the development and testing of surgical techniques. He is a notable researcher in the United States in use of fibrin glue. Spotnitz serves as a heart surgeon in the University of Virginia Health System. He also previously served as the director of the hospital's Tissue Adhesive Center, which promoted and advanced the use of adhesives in surgery. He currently serves as the director of the Surgical Therapeutic Advancement Center, a successor program conducting more generalized research in surgical procedures.

Tissue engineered heart valves (TEHV) offer a new and advancing proposed treatment of creating a living heart valve for people who are in need of either a full or partial heart valve replacement. Currently, there are over a quarter of a million prosthetic heart valves implanted annually, and the number of patients requiring replacement surgeries is only suspected to rise and even triple over the next fifty years. While current treatments offered such as mechanical valves or biological valves are not deleterious to one's health, they both have their own limitations in that mechanical valves necessitate the lifelong use of anticoagulants while biological valves are susceptible to structural degradation and reoperation. Thus, in situ (in its original position or place) tissue engineering of heart valves serves as a novel approach that explores the use creating a living heart valve composed of the host's own cells that is capable of growing, adapting, and interacting within the human body's biological system.


  1. AorTech buys TissueMed's heart valve division. Elservier Business Intelligence, 1999. http://www.elsevierbi.com/deals/199910268
  2. Kumar, P; Athanasiou T; Mussa S; Wood AJ. (2003). "Ten year experience with Aspire (Tissuemed) porcine bioprosthesis: single centre experience". Cardiovascular Surgery. 11 (2): 131–7. doi:10.1016/s0967-2109(03)00011-5. PMID   12664048.
  3. Goldsmith, IR; Spyt TJ; Boehm M; Kendall S; Rosin MD. (2001). "Midterm evaluation of the Tissuemed (Aspire) porcine bioprosthesis: 493 patients, 506 bioprostheses". The Annals of Thoracic Surgery. 71 (5): 1471–6. doi:10.1016/s0003-4975(01)02397-9. PMID   11383785.
  4. Birch, JF; Mandley DJ; Williams SL; Worrall DR; Trotter PJ; Wilkinson F; Bell PR. (2000). "Methylene blue based protein solder for vascular anastomoses: an in vitro burst pressure study". Lasers in Surgery and Medicine. 26 (3): 323–9. doi:10.1002/(sici)1096-9101(2000)26:3<323::aid-lsm11>3.0.co;2-r. PMID   10738296. S2CID   35428707.
  5. USpatent 6,239,190,"Enhancement of activation for biological tissue adhesives, bonding agents and sealants using "color change" chromophores",published 2001, assigned to Tissuemed Ltd
  6. Ferroli, P; Acerbi, F; Broggi, M; Schiariti, M; Albanese, E; Tringali, G; Franzini, A; Broggi, G (March–April 2013). "A novel impermeable adhesive membrane to reinforce dural closure: a preliminary retrospective study on 119 consecutive high-risk patients". World Neurosurgery. 79 (3–4): 551–7. doi:10.1016/j.wneu.2011.09.022. PMID   22120260.
  7. Schiariti M, Acerbi F, Broggi M, Tringali G, Raggi A, Broggi G, Ferroli P. Two alternative dural sealing techniques in posterior fossa surgery: (Polylactide-co-glycolide) self-adhesive resorbable membrane versus polyethylene glycol hydrogel. Surg Neurol Int. 2014 Dec 3;5:171. doi: 10.4103/2152-7806.146154.
  8. "Tissuemed wins China's OK for TissuePatch surgical sealant – MassDevice". www.massdevice.com. June 2016. Retrieved October 16, 2017.
  9. Wright, Greg (December 14, 2021). "Leeds based medical device manufacturer Tissuemed is acquired by US-based Becton Dickinson". Yorkshire Post. Retrieved August 25, 2022.