Fringe science refers to ideas whose attributes include being highly speculative or relying on premises already refuted. Fringe science theories are often advanced by people who have no traditional academic science background, or by researchers outside the mainstream discipline. The general public has difficulty distinguishing between science and its imitators, and in some cases, a "yearning to believe or a generalized suspicion of experts is a very potent incentive to accepting pseudoscientific claims".
Aubrey David Nicholas Jasper de Grey is an English biomedical gerontologist. He is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). De Grey is known for his view that medical technology may enable human beings alive today not to die from age-related causes. As an amateur mathematician, he has contributed to the study of the Hadwiger–Nelson problem in geometric graph theory, making the first progress on the problem in over 60 years.
Karl Edward Wagner was an American writer, poet, editor, and publisher of horror, science fiction, and heroic fantasy, who was born in Knoxville, Tennessee and originally trained as a psychiatrist. He wrote numerous dark fantasy and horror stories. As an editor, he created a three-volume set of Robert E. Howard's Conan the Barbarian fiction restored to its original form as written, and edited the long-running and genre-defining The Year's Best Horror Stories series for DAW Books. His Carcosa publishing company issued four volumes of the best stories by some of the major authors of the so-called Golden Age pulp magazines. He is possibly best known for his creation of a series of stories featuring the character Kane, the Mystic Swordsman.
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease. SENS was first defined by British biogerontologist Aubrey de Grey. Many mainstream scientists believe that it is a fringe theory. De Grey later highlighted similarities and differences of SENS to subsequent categorization systems of the biology of aging, such as the highly influential Hallmarks of Aging published in 2013.
Following is a list of topics related to life extension:
The MIT Department of Biology is a center for research and teaching in the life sciences. Many members of the faculty hold joint appointments with other departments at MIT and with outside institutions.
Leonard Pershing Guarente is an American biologist best known for his research on life span extension in the budding yeast Saccharomyces cerevisiae, roundworms, and mice. He is a Novartis Professor of Biology at the Massachusetts Institute of Technology.
David Andrew Sinclair is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard. He is the co-author of Lifespan: Why We Age – and Why We Don't Have To.
Cynthia Jane Kenyon is an American molecular biologist and biogerontologist known for her genetic dissection of aging in a widely used model organism, the roundworm Caenorhabditis elegans. She is the vice president of aging research at Calico Research Labs, and emeritus professor of biochemistry and biophysics at the University of California, San Francisco (UCSF).
The following outline is provided as an overview of and topical guide to life extension:
Preston "Pete" Wayne Estep III is an American biologist and science and technology advocate. He is a graduate of Cornell University, where he did neuroscience research, and he earned a Ph.D. in Genetics from Harvard University. He did his doctoral research in the laboratory of genomics pioneer Professor George M. Church at Harvard Medical School.
Brian K. Kennedy is a scientist, performing research on the science of aging and healthy longevity. Since 2017, he has served as a Distinguished Professor in Biochemistry and Physiology at the Yong Loo Lin School of Medicine in the National University of Singapore, where he is currently the Director of the Healthy Longevity Translational Research Programme and the Asian Centre for Reproductive Longevity and Equality. His efforts have been directed at building world-class longevity research in Singapore.
Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, the company was focused on developing Sinclair's research into activators of sirtuins, work that began in the laboratory of Leonard P. Guarente where Sinclair worked as a post-doc before starting his own lab.
Nicanor Robles Austriaco, Jr. OP is a Filipino-American molecular biologist and Catholic priest. He is a professor of biology and professor of theology at Providence College, in Providence, Rhode Island, and a research fellow at the Center for Theology, Religious Studies, and Ethics, at the University of Santo Tomas in the Philippines.
Jan Vijg is the Lola and Saul Kramer Chairperson in Molecular Genetics at the Department of Genetics at the Albert Einstein College of Medicine, New York City, United States. Prior to this appointment, he was a professor at the Buck Institute for Research on Aging.
In biogerontology, the disposable soma theory of aging states that organisms age due to an evolutionary trade-off between growth, reproduction, and DNA repair maintenance. Formulated by British biologist Thomas Kirkwood, the disposable soma theory explains that an organism only has a limited amount of resources that it can allocate to its various cellular processes. Therefore, a greater investment in growth and reproduction would result in reduced investment in DNA repair maintenance, leading to increased cellular damage, shortened telomeres, accumulation of mutations, compromised stem cells, and ultimately, senescence. Although many models, both animal and human, have appeared to support this theory, parts of it are still controversial. Specifically, while the evolutionary trade-off between growth and aging has been well established, the relationship between reproduction and aging is still without scientific consensus, and the cellular mechanisms largely undiscovered.
The 2018 New York's 14th congressional district election was held on Tuesday, November 6, 2018. The primaries for New York's federal elections were held earlier in the year on June 26. Alexandria Ocasio-Cortez defeated incumbent congressman Joe Crowley in the primary, and went on to defeat Republican opponent Anthony Pappas in the general election.
