Steven N. Austad is the Protective Life Endowed Chair in Health Aging Research, a Distinguished professor and Chair of the Department of Biology at the University of Alabama at Birmingham from 2014 to 2022. [1]
After earning a BA in English literature from UCLA, Austad left academia for a number of years during which among other things, he drove a taxi cab in New York City, worked as a newspaper reporter, and trained lions for television and movies. His interest in biology was awakened by his lion training, and he returned to academics to study biology more formally. He received a BS in biology from California State University, Northridge and his PhD in biology from Purdue University. [2] After postdoctoral research at the University of New Mexico, he accepted a position as assistant professor in the Department of Organismic and Evolution Biology at Harvard University in 1986. Leaving Harvard as an associate professor in 1993, he moved to the University of Idaho where he became full professor. From 2004 to 2013, he was a professor at the University of Texas Health Science Center at San Antonio. He served as interim director of the Barshop Institute before moving to his current position in 2014.
Dr. Austad is the Founding Director of the UAB Nathan Shock Center of Excellence in the Basic Biology of Aging, one of only 6 such Centers in the United States. He is also Senior Scientific Director of the American Federation for Aging Research (AFAR), a New York-based philanthropic organization which supports basic and clinical research and training to support and advance healthy aging.
In the past, his research was primarily field-based, particularly with opossums. He discovered that opossums off the predator-free island of Sapelo Island lived 25% longer than their cousins on the mainland Georgia. [3] Betting against S. Jay Olshansky, he predicted that there will be someone at least 150 years of age by the year 2150 who was born before 2000.
His current research interests include discovering why organisms age at different rates, particularly in especially long-lived organisms such as quahog clams and hydra. He is also interested in studying indicators of animal healthspan as well as the effects of rapamycin on mouse healthspan and sex differences in mechanisms of aging. [4]
Dr. Austad's research and teaching have won multiple local, national, and international awards, including the Fifth Nathan A. Shock Award, the Robert W. Kleemeier award, Purdue University Outstanding Alumnus Award, the Irving S. Wright Award of Distinction, the Fondation IPSEN Longevity Prize, and the Caroline P. and Charles W. Ireland Prize for Scholarly Distinction. He is a fellow of the Gerontological Society of America and the American Association for the Advancement of Science. In 2021, he was appointed Protective Life Endowed Chair of Health Aging Research at the University of Alabama at Birmingham.
He is author of more than 200 scientific articles and more than 150 newspaper columns on science. His book Why We Age: What Science Is Discovering about the Body’s Journey Through Life has been translated into 8 languages. His new book, Methuselah's Zoo: what nature can teach us about living longer, healthier lives was released by MIT Press in 2022 and reviewed favorably in Science Magazine. Between 2012 and 2013, he wrote a series of biweekly columns for the San Antonio Express News called "On Aging". [5] Until recently, he currently wrote a similar biweekly column on science for AL.com as well as occasional pieces for the Huffington Post. These columns can be found at his website www.stevenaustad.com and a selection of them are available in a book titled To Err is Human, To Admit It is Not and other Essays (2022).
Senescence or biological aging is the gradual deterioration of functional characteristics in living organisms. The word senescence can refer to either cellular senescence or to senescence of the whole organism. Organismal senescence involves an increase in death rates and/or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle. However, the resulting effects of senescence can be delayed. The 1934 discovery that calorie restriction can extend lifespans by 50% in rats, the existence of species having negligible senescence, and the existence of potentially immortal organisms such as members of the genus Hydra have motivated research into delaying senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases.
Longevity may refer to especially long-lived members of a population, whereas life expectancy is defined statistically as the average number of years remaining at a given age. For example, a population's life expectancy at birth is the same as the average age at death for all people born in the same year.
Aubrey David Nicholas Jasper de Grey is an English biomedical gerontologist. He is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). De Grey is known for his view that medical technology may enable human beings alive today not to die from age-related causes. As an amateur mathematician, he has contributed to the study of the Hadwiger–Nelson problem in geometric graph theory, making the first progress on the problem in over 60 years.
Seymour Benzer was an American physicist, molecular biologist and behavioral geneticist. His career began during the molecular biology revolution of the 1950s, and he eventually rose to prominence in the fields of molecular and behavioral genetics. He led a productive genetics research lab both at Purdue University and as the James G. Boswell Professor of Neuroscience, emeritus, at the California Institute of Technology.
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease. SENS was first defined by British biogerontologist Aubrey de Grey. Many mainstream scientists believe that it is a fringe theory. De Grey later highlighted similarities and differences of SENS to subsequent categorization systems of the biology of aging, such as the highly influential Hallmarks of Aging published in 2013.
Stuart Jay Olshansky is a professor in the School of Public Health at the University of Illinois at Chicago concentrating on biodemography and gerontology and is co-founder and Chief Scientist at Lapetus Solutions, Inc.
Cynthia Jane Kenyon is an American molecular biologist and biogerontologist known for her genetic dissection of aging in a widely used model organism, the roundworm Caenorhabditis elegans. She is the vice president of aging research at Calico Research Labs, and emeritus professor of biochemistry and biophysics at the University of California, San Francisco (UCSF).
Matt Kaeberlein is an American biologist and biogerontologist best known for his research on evolutionarily conserved mechanisms of aging. He is currently a professor of pathology at the University of Washington in Seattle.
David Bradley Allison is an American obesity researcher, biostatistician, and psychologist. He is the dean of the Indiana University School of Public Health-Bloomington and, in 2007, was one of the top 10 scientists in the world awarded the most NIH grants. Allison was previously Distinguished Professor, Quetelet Endowed Professor, and Director of the NIH-funded Nutrition Obesity Research Center at the University of Alabama at Birmingham (UAB).
The Methuselah Foundation is an American-based global non-profit organization based in Springfield, Virginia, with a declared mission to "make 90 the new 50 by 2030" by supporting tissue engineering and regenerative medicine therapies. The organization was originally incorporated by David Gobel in 2001 as the Performance Prize Society, a name inspired by the British governments Longitude Act, which offered monetary rewards for anyone who could devise a portable, practical solution for determining a ship's longitude.
Charles Brenner is the inaugural Alfred E Mann Family Foundation Chair of the Department of Diabetes & Cancer Metabolism at the Beckman Research Institute of the City of Hope National Medical Center. Brenner previously held the Roy J. Carver Chair in Biochemistry and was head of biochemistry at the University of Iowa.
David Gobel is an American philanthropist, entrepreneur, inventor, and futurist. He is co-founder and CEO of the Methuselah Foundation, CEO of the Methuselah Fund, and one of the first to publicly advance the idea of longevity escape velocity, even before this term was formulated.
Victor Darley-Usmar is a free-radical biologist and biochemist, the UAB Endowed Professor in Mitochondrial Medicine and Pathology at the University of Alabama at Birmingham. Darley-Usmar also contributed to a book titled Microbes, Bugs & Wonder Drugs, a science book written for young readers and their families.
Arlan Richardson is the Professor of Geriatric Medicine and the Donald W. Reynolds Endowed Chair of Aging Research at OUHSC and Senior VA Career Scientist at the Oklahoma City VA Medical Center. His research interests include Calorie Restriction and Aging, Oxidative Stress, and Molecular Biology of Aging. He is the director of the Oklahoma Nathan Shock Center on Aging. He is listed in Who's Who in Gerontology and is the founder of the Barshop Institute. In 2016, Richardson told CNN that Rapamycin is the best drug he'd ever seen in slowing aging.
Luigi Fontana, M.D., PhD, FRACP is a physician scientist who studies healthy longevity, with a focus on calorie restriction, endurance exercise and metabolism. He is the Leonard P Ullmann Chair in Translational Metabolic Health at the Charles Perkins Centre, where he directs the Charles Perkins Centre Royal Prince Alfred Clinic and the CPC RPA Health for Life Research, Educational and Clinical Program. He is also a Professor of Medicine and Nutrition in the Faculty of Medicine and Health at the University of Sydney and a Clinical Academic in the Department of Endocrinology at the Royal Prince Alfred Hospital in Sydney, Australia. Fontana was a professor of medicine and co-Director of the Healthy Longevity Program at Washington University School of Medicine.
Keshav K. Singh is one of the global leaders in the field of mitochondria research and medicine. He is the Joy and Bill Harbert Endowed Chair, Professor of Genetics, Pathology and Environmental Health and the Director of the Cancer Genetics Program at the University of Alabama at Birmingham (UAB). Keshav K. Singh is also the founding editor-in-chief of the journal Mitochondrion., founder of the Mitochondria Research and Medicine Society (USA) and the Society for Mitochondrial Research and Medicine (India)
Lifespan: Why We Age – and Why We Don't Have To is a book by David A. Sinclair.
Mona N. Fouad is an Egyptian-American physician. Fouad is the inaugural holder of the Edward E. Partridge, M.D., Endowed Chair for Cancer Disparity Research at the University of Alabama at Birmingham. As a result of her "lifetime of exceptional work in health and medicine," Fouad was also elected a member of the National Academy of Medicine in 2017.
Longevity Quotient (LQ) is a simplified measure to enable normalized comparisons of various species' longevity. It shares some similarity with measures such as Intelligence Quotient. It originated with Steven N. Austad and Kathleen E Fischer's 1991 paper on mammalian aging.
Trygve Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham (UAB) in the department of Biology. Coining the term “epigenetics diet” in 2011, Tollefsbol has been a leader in the field of phytochemical-based epigenetic mechanisms to prevent cancer. In his role as founder and chief editor for Elsevier's Translational Epigenetics, an internationally recognized series, he has directed the publication of almost 50 books on the topic of epigenetics.