Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years.
The word "longevity" is sometimes used as a synonym for "life expectancy" in demography. However, the term longevity is sometimes meant to refer only to especially long-lived members of a population, whereas life expectancy is always defined statistically as the average number of years remaining at a given age. For example, a population's life expectancy at birth is the same as the average age at death for all people born in the same year. Longevity is best thought of as a term for general audiences meaning 'typical length of life' and specific statistical definitions should be clarified when necessary.
Maximum life span is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death. The term can also denote an estimate of the maximum amount of time that a member of a given species could survive between birth and death, provided circumstances that are optimal to that member's longevity.
Leonard Hayflick is a Professor of Anatomy at the UCSF School of Medicine, and was Professor of Medical Microbiology at Stanford University School of Medicine. He is a past president of the Gerontological Society of America and was a founding member of the council of the National Institute on Aging (NIA). The recipient of a number of research prizes and awards, including the 1991 Sandoz Prize for Gerontological Research, he has studied the aging process for more than fifty years. He is known for discovering that normal human cells divide for a limited number of times in vitro. This is known as the Hayflick limit. His discoveries overturned a 60-year old dogma that all cultured cells are immortal. Hayflick demonstrated that normal cells have a memory and can remember at what doubling level they have reached. He demonstrated that his normal human cell strains were free from contaminating viruses. His cell strain WI-38 soon replaced primary monkey kidney cells and became the substrate for the production of most of the world's human virus vaccines. Hayflick discovered that the etiological agent of primary atypical pneumonia was not a virus as previously believed. He was the first to cultivate the causative organism called a mycoplasma, the smallest free-living organism, which Hayflick isolated on a unique culture medium that bears his name. He named the organism Mycoplasma pneumoniae.
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodical repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease. SENS was first defined by British biogerontologist Aubrey de Grey.
The USC Leonard Davis School of Gerontology is one of the seventeen academic divisions of the University of Southern California in Los Angeles, focusing in undergraduate and graduate programs in gerontology,
Biodemography is a multidisciplinary approach, integrating biological knowledge with demographic research on human longevity and survival. Biodemographic studies are important for understanding the driving forces of the current longevity revolution, forecasting the future of human longevity, and identification of new strategies for further increase in healthy and productive life span.
The American Academy of Anti-Aging Medicine (A4M) is a United States 501(c)(3) nonprofit organization that promotes the field of anti-aging medicine, and the organization trains and certifies physicians in this specialty. As of 2011, approximately 26,000 practitioners had been given A4M certificates. The field of anti-aging medicine is not recognized by established medical organizations, such as the American Board of Medical Specialties (ABMS) and the American Medical Association (AMA). The Academy's activities include lobbying and public relations. The A4M was founded in 1993 by osteopathic physicians Robert M. Goldman and Ronald Klatz, and as of 2013 claimed 26,000 members from 120 countries.
Following is a list of topics related to life extension:
Biodemography is the science dealing with the integration of biological theory and demography.
Eileen M. Crimmins is the AARP Chair in Gerontology at the USC Davis School of Gerontology of the University of Southern California. Her work focuses on the connections between socioeconomic factors and life expectancy and other health outcomes.
James W. Vaupel, is an American scientist in the fields of aging research, biodemography, and formal demography. He has been instrumental in developing and advancing the idea of the plasticity of longevity, and pioneered research on the heterogeneity of mortality risks and on the deceleration of death rates at the highest ages.
The Journals of Gerontology are the first scientific journals on aging published in the United States. The publication is separated into four separate peer-reviewed scientific journals, each with its own editor, and published in two series. The Journal of Gerontology: Biological Sciences and the Journal of Gerontology: Medical Sciences are housed within The Journals of Gerontology, Series A; the Journal of Gerontology: Psychological Sciences and the Journal of Gerontology: Social Sciences are housed within The Journals of Gerontology, Series B. The journals are published by Oxford University Press on behalf of The Gerontological Society of America.
Caleb Ellicott Finch is an American academic who is a professor at the USC Davis School of Gerontology. Finch's research focuses on aging in humans, with a specialization in cell biology and Alzheimer's disease.
The anti-aging movement is a social movement devoted to eliminating or reversing aging, or reducing the effects of it. A substantial portion of the attention of the movement is on the possibilities for life extension, but there is also interest in techniques such as cosmetic surgery which ameliorate the effects of aging rather than delay or defeat it.
Madhu Sudan Kanungo was an Indian scientist in the field of gerontology and neuroscience as well as a teacher of molecular biology and biochemistry. He is known for his theories on how gene expression changes with age and the role of this phenomenon in ageing, which is a widely accepted as "Gene expression theory of Aging". In recognition of his contributions, he was awarded India's fourth highest civilian award, Padma Shri in 2005. He held the post of BHU Emeritus professor in zoology at the Banaras Hindu University and was also the Chancellor, Nagaland University till his death.
Linda P. Fried is an American geriatrician and epidemiologist and the first female Dean of Columbia University's Mailman School of Public Health. Her research career has focused on frailty, healthy aging, and how society can successfully transition to benefit from an aging population.
Holly Brown-Borg is an American biologist and biogerontologist best known for her research on the regulation of lifespan by growth hormone. She is the Chester Fritz Distinguished Professor of Pharmacology, Physiology & Therapeutics at the University of North Dakota School of Medicine and Health Sciences.
This timeline lists notable events in the history of research of senescence or biological aging. People have long since been interested in how to make their lives longer and healthier. Already the most anсient Egyptian, Indian and Chinese books contain reasoning about aging. Ancient Egyptians used garlic in large quantities to extend their lifespan. Hippocrates in his Aphorisms and Aristotle (384 – 322 BC) in On youth and old age expresses their opinions about reasons for old age and gave advice about lifestyle. Medieval Persian physician Ibn Sina, known in the West as Avicenna, summarized achievements of the earlier generations about this issue.
