Tom Misteli

Last updated
Tom Misteli.jpg

Tom Misteli is a Swiss-born (Solothurn) cell biologist who has pioneered the field of genome cell biology. He is the Director of the Center for Cancer Research at the National Cancer Institute, NIH.

Misteli is best known for his work on elucidation of how genomes function in living cells. [Ref 1] While a post-doc at the Cold Spring Harbor Laboratory, New York, United States, he developed methods to visualize proteins in the nucleus of living mammalian cells allowing for the first time to study gene expression in intact cells. His more recent work focuses on the role of genome organization and nuclear architecture on differentiation and disease. His cell biological elucidation of the mechanisms involved in the pre-mature aging disease Hutchinson–Gilford progeria syndrome have revealed novel mechanisms of human aging. [Ref 2]

He is an NIH Distinguished Investigator at the National Cancer Institute, NIH, Bethesda, MD, United States. He was the Editor-in-Chief of The Journal of Cell Biology (2009-2015) and of Current Opinion in Cell Biology. He serves on the editorial boards of Science , Cell and PLOS Biology . He co-authored the influential report by the US National Academy of Sciences "Toward Precision Medicine".

For his work he has won numerous awards including the Flemming Award, The Gold Medal of the Charles University, The Beerman Award,the Feulgen Prize and the E.B. Wilson Award. He is an elected Fellow of the American Society for Cell Biology.[ citation needed ]

Related Research Articles

<span class="mw-page-title-main">Mitochondrial DNA</span> DNA located in mitochondria

Mitochondrial DNA is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, such as adenosine triphosphate (ATP). Mitochondrial DNA is only a small portion of the DNA in a eukaryotic cell; most of the DNA can be found in the cell nucleus and, in plants and algae, also in plastids such as chloroplasts.

Ronald Mark Evans is an American Biologist, Professor and Head of the Salk’s Gene Expression Laboratory, and the March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute for Biological Studies in La Jolla, California and a Howard Hughes Medical Institute Investigator. Dr. Ronald M. Evans is known for his original discoveries of nuclear hormone receptors (NR), a special class of transcriptional factor, and the elucidation of their universal mechanism of action, a process that governs how lipophilic hormones and drugs regulate virtually every developmental and metabolic pathway in animals and humans. Nowadays, NRs are among the most widely investigated group of pharmaceutical targets in the world, already yielding benefits in drug discovery for cancer, muscular dystrophies, osteoporosis, type II diabetes, obesity, and cardiovascular diseases. His current research focuses on the function of nuclear hormone signaling and their function in metabolism and cancer.

<span class="mw-page-title-main">John Gurdon</span> English developmental biologist (born 1933)

Sir John Bertrand Gurdon is a British developmental biologist, best known for his pioneering research in nuclear transplantation and cloning.

Pamela Ann Silver is an American cell and systems biologist and a bioengineer. She holds the Elliot T. and Onie H. Adams Professorship of Biochemistry and Systems Biology at Harvard Medical School in the Department of Systems Biology. Silver is one of the founding Core Faculty Members of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

<span class="mw-page-title-main">Stuart Schreiber</span> American chemist

Stuart Schreiber, Ph.D. is the Morris Loeb Research Professor at Harvard University, a co-Founder of the Broad Institute, Howard Hughes Medical Institute Investigator, Emeritus, and a member of the National Academy of Sciences and National Academy of Medicine. His work integrates chemical biology and human biology to advance the science of therapeutics. Key advances include the discovery that small molecules can function as “molecular glues” that promote protein–protein interactions, the co-discovery of mTOR and its role in nutrient-response signaling, the discovery of histone deacetylases and the demonstration that chromatin marks regulate gene expression, the development and application of diversity-oriented synthesis to microbial therapeutics, and the discovery of vulnerabilities of cancer cells linked to genetic, lineage and cell-state features, including ferroptotic vulnerabilities. His notable awards include the Wolf Prize in Chemistry and the Arthur Cope Award. His approach to discovering new therapeutics guided many biotechnology companies that he founded, including Vertex Pharmaceuticals and Ariad Pharmaceuticals. He has founded or co-founded 14 biotechnology companies, which have developed 16 first-in-human approved drugs or advanced clinical candidates.

<span class="mw-page-title-main">Raúl Rabadán</span> Spanish-American physicist and biologist (born 1974)

Raúl Rabadán is a Spanish-American theoretical physicist and computational biologist. He is currently the Gerald and Janet Carrus Professor in the Department of Systems Biology, Biomedical Informatics and Surgery at Columbia University. He is the director of the Program for Mathematical Genomics at Columbia University and director of the Center for Topology of Cancer Evolution and Heterogeneity. At Columbia, he has put together a highly interdisciplinary lab with researchers from the fields of mathematics, physics, computer science, engineering, and medicine, with the common goal of solving pressing biomedical problems through quantitative computational models. Rabadan's current interest focuses on uncovering patterns of evolution in biological systems—in particular, viruses and cancer.

<span class="mw-page-title-main">David Haussler</span> American bioinformatician

David Haussler is an American bioinformatician known for his work leading the team that assembled the first human genome sequence in the race to complete the Human Genome Project and subsequently for comparative genome analysis that deepens understanding the molecular function and evolution of the genome.

<span class="mw-page-title-main">Gregory Petsko</span> American biochemist and academic

Gregory A. Petsko is an American biochemist and member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. He is currently Professor of Neurology at the Ann Romney Center for Neurologic Diseases at Harvard Medical School and Brigham and Women's Hospital. He formerly had an endowed professorship in Neurology and Neuroscience at Weill Cornell Medical College and is still an adjunct professor of Biomedical Engineering at Cornell University, and is also the Gyula and Katica Tauber Professor, Emeritus, in biochemistry and chemistry at Brandeis University. On October 24, 2023, in a ceremony in the East Room of the White House, President Joe Biden presented Gregory Petsko and eight others with the National Medal of Science, the highest honor the United States can bestow on a scientist and engineer.

Jeffrey Ivan Gordon is a biologist and the Dr. Robert J. Glaser Distinguished University Professor and Director of the Center for Genome Sciences and Systems Biology at Washington University in St. Louis. He is internationally known for his research on gastrointestinal development and how gut microbial communities affect normal intestinal function, shape various aspects of human physiology including our nutritional status, and affect predisposition to diseases. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, the Institute of Medicine of the National Academies, and the American Philosophical Society.

<span class="mw-page-title-main">Robert B. Darnell</span> American biochemist (born 1957)

Robert Bernard Darnell is an American neurooncologist and neuroscientist, founding director and former CEO of the New York Genome Center, the Robert and Harriet Heilbrunn Professor of Cancer Biology at The Rockefeller University, and an Investigator of the Howard Hughes Medical Institute. His research into rare autoimmune brain diseases led to the invention of the HITS-CLIP method to study RNA regulation, and he is developing ways to explore the regulatory portions—known as the "dark matter"—of the human genome.

Ajit Varki is a physician-scientist who is distinguished professor of medicine and cellular and molecular medicine, founding co-director of the Glycobiology Research and Training Center at the University of California, San Diego (UCSD), and founding co-director of the UCSD/Salk Center for Academic Research and Training in Anthropogeny (CARTA). He is also executive editor of the textbook Essentials of Glycobiology and distinguished visiting professor at the Indian Institute of Technology in Madras and the National Center for Biological Sciences in Bangalore. He is a specialist advisor to the Human Gene Nomenclature Committee.

Thomas J. Kelly is an American cancer researcher whose work focuses on the molecular mechanisms of DNA replication. Kelly is director of the Sloan-Kettering Institute, the basic research arm of the Memorial Sloan-Kettering Cancer Center. He holds the Center's Benno C. Schmidt Chair of Cancer Research.

<span class="mw-page-title-main">David L. Spector</span>

David L. Spector is a cell and molecular biologist best recognized for his research on gene expression and nuclear dynamics. He is currently a professor at Cold Spring Harbor Laboratory (CSHL). Since 2007, he has served as Director of Research of CSHL.

<span class="mw-page-title-main">William A. Haseltine</span> American biologist (born 1944)

William A. Haseltine is an American scientist, businessman, author, and philanthropist. He is known for his groundbreaking work on HIV/AIDS and the human genome.

<span class="mw-page-title-main">Eric Schadt</span> American scientist

Eric Emil Schadt is an American mathematician and computational biologist. He is founder and former chief executive officer of Sema4, a patient-centered health intelligence company, and dean for precision medicine and Mount Sinai Professor in Predictive Health and Computational Biology at the Icahn School of Medicine at Mount Sinai. He was previously founding director of the Icahn Institute for Genomics and Multiscale Biology and chair of the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai.

Ashok Venkitaraman is a British cancer researcher of Indian origin. He is the Director of the Cancer Science Institute of Singapore, a Distinguished Professor of Medicine at the National University of Singapore, and Program Director at A*STAR, Singapore. From 1998 to 2020, he was the inaugural holder of the Ursula Zoellner Professorship of Cancer Research at the University of Cambridge, a Professorial Fellow at Pembroke College, Cambridge, and from 2006 to 2019, was the Director of the Medical Research Council Cancer Unit

<span class="mw-page-title-main">Richard A. Young</span> American geneticist (born 1954)

Richard Allen Young is an American geneticist, a Member of Whitehead Institute, and a professor of biology at the Massachusetts Institute of Technology. He is a pioneer in the systems biology of gene control who has developed genomics technologies and concepts key to understanding gene control in human health and disease. He has served as an advisor to the World Health Organization and the National Institutes of Health. He is a member of the National Academy of Sciences and the National Academy of Medicine. Scientific American has recognized him as one of the top 50 leaders in science, technology and business. Young is among the most Highly Cited Researchers in his field.

<span class="mw-page-title-main">Manolis Kellis</span> Greek-born computational biologist

Manolis Kellis is a professor of Computer Science at the Massachusetts Institute of Technology (MIT) in the area of Computational Biology and a member of the Broad Institute of MIT and Harvard. He is the head of the Computational Biology Group at MIT and is a Principal Investigator in the Computer Science and Artificial Intelligence Lab (CSAIL) at MIT.

<span class="mw-page-title-main">Luciano Marraffini</span> American Microbiologist

Luciano Marraffini is an Argentinian-American microbiologist. He is currently professor and head of the laboratory of bacteriology at The Rockefeller University. He is recognized for his work on CRISPR-Cas systems, being one of the first scientists to elucidate how these systems work at the molecular level.

Eran Meshorer is an Israeli scientist, professor of epigenetics and stem cells at the Alexander Silberman Institute of Life Sciences, and The Edmond and Lily Safra Center for Brain Sciences, the Hebrew University of Jerusalem. Meshorer is the Arthur Gutterman Chair for Stem Cell Research.

References

    1. Misteli, Tom (February 1, 2011). "The Inner Life of the Genome". Scientific American. 304 (2): 66–73. Bibcode:2011SciAm.304b..66M. doi:10.1038/scientificamerican0211-66. PMC   6363115 . PMID   21319544.
    2. Scaffidi, Paola; Misteli, Tom (2006). "Lamin A-Dependent Nuclear Defects in Human Aging". Science. 312 (5776): 1059–1063. Bibcode:2006Sci...312.1059S. doi:10.1126/science.1127168. PMC   1855250 . PMID   16645051.