Transformer (gene)

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Alternative splicing of the Drosophila Transformer gene product. Transformer splicing.gif
Alternative splicing of the DrosophilaTransformer gene product.
Female-specific protein transformer
Identifiers
SymbolTra
Pfam PF06495
InterPro IPR010519
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary
Transformer
Identifiers
Organism Drosophila melanogaster
Symboltra
Entrez 39849
RefSeq (mRNA) NM_079390.3
RefSeq (Prot) NP_524114.1
UniProt P11596
Other data
Chromosome 3L: 16.59 - 16.59 Mb
Search for
Structures Swiss-model
Domains InterPro
Transformer 2
Identifiers
Organism Drosophila melanogaster
Symboltra2
Entrez 36619
RefSeq (mRNA) NM_057416.3
RefSeq (Prot) NP_476764.1
UniProt P19018
Other data
Chromosome 2R: 14.6 - 14.6 Mb
Search for
Structures Swiss-model
Domains InterPro

Transformer (tra) is a family of genes which regulate sex determination in insects such as flies. [1] [2] Among its effects, it ( P11596 ) regulates differences between males and females in Drosophila fruit flies. [3]

The tra-2 gene ( P19018 ) is needed for sexual differentiation in female fruit flies, and for spermatogenesis in the males. It is not in the same protein family as tra, but instead works together with it in the splicing enhancer complex. [4] [5]

References

  1. ↑ Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–383. doi:10.1016/j.gde.2010.05.001. hdl: 11370/2174764d-bd1b-4e1f-b142-90aced0c3e55 . PMID   20570131. S2CID   205003182.
  2. ↑ An X, Ota T, O'Neil MT, Steinmann-Zwicky M, Yamamoto D, et al. "tra - transformer". Gene Review. Nature Genetics. Archived from the original on 5 August 2021. Retrieved 7 December 2017.
  3. ↑ Rideout EJ, Narsaiya MS, Grewal SS (December 2015). "The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size". PLOS Genetics. 11 (12): e1005683. doi: 10.1371/journal.pgen.1005683 . PMC   4692505 . PMID   26710087.
  4. ↑ Amrein H, Gorman M, Nöthiger R (December 1988). "The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein". Cell. 55 (6): 1025–1035. doi:10.1016/0092-8674(88)90247-4. PMID   3144434. S2CID   21183373.
  5. ↑ "Transformer-2 sex-determining protein". UniProt. Retrieved 7 December 2017.
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