Trophos

Last updated

Trophos
Type Privately held company
Founded Marseille, France (1999 (1999))
Founder
  • Christopher Henderson
  • Olivier Pourquie
  • Jean-Louis Kraus
  • Antoine Beret
  • Michel Delaage
Defunct2015 (2015)
FateAcquired by Hoffmann-La Roche
Headquarters
France  OOjs UI icon edit-ltr-progressive.svg

Trophos was a biopharmaceutical company specialising in the discovery and development of novel therapeutics to treat both orphan neurodegenerative diseases and more prevalent disorders.[ citation needed ]

Trophos was founded in 1999 in Marseille by three scientists: Christopher Henderson, Olivier Pourquie and Jean-Louis Kraus, and two entrepreneurs: Antoine Beret and Michel Delaage. Trophos' lead compound was olesoxime (TRO19622), [1] [2] a mitochondrial targeted compound developed ot treat neurodegenerative diseases. [3] [4]

In January 2015, Hoffmann-La Roche announced its intention to buy Trophos for 120,000,000 upfront and up to 350,000,000 in milestone performance payments. [5] [6] The deal was completed shortly afterwards.

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References

  1. Bordet, T.; Buisson, B.; Michaud, M.; Drouot, C.; Galea, P.; Delaage, P.; Akentieva, N. P.; Evers, A. S.; Covey, D. F.; Ostuni, M. A.; Lacapere, J.-J.; Massaad, C.; Schumacher, M.; Steidl, E.-M.; Maux, D.; Delaage, M.; Henderson, C. E.; Pruss, R. M. (2007). "Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis". Journal of Pharmacology and Experimental Therapeutics. 322 (2): 709. doi:10.1124/jpet.107.123000. PMID   17496168.
  2. "olesoxime". UKMi New Drugs Online Database. Retrieved 2 January 2016.CS1 maint: discouraged parameter (link)
  3. "Effect of TRO19622 in the Treatment of Patients With Chemotherapy Induced Peripheral Neuropathy". ClinicalTrials.gov. 5 February 2010. Retrieved 3 October 2010.CS1 maint: discouraged parameter (link)
  4. "Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)". ClinicalTrials.gov. May 2010. Retrieved 3 October 2010.CS1 maint: discouraged parameter (link)
  5. Franklin, Joshua (16 January 2015). "Roche buys France's Trophos to expand in neuromuscular disease". Reuters. Retrieved 30 December 2015.
  6. Staff (15 February 2015). "Roche to Buy Trophos for Up-to-$543M". Genetic Engineering & Biotechnology News (paper). 35 (4). p. 6.

Further reading