USP15

Last updated
USP15
Protein USP15 PDB 1w6v.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases USP15 , UNPH-2, UNPH4, ubiquitin specific peptidase 15
External IDs OMIM: 604731 MGI: 101857 HomoloGene: 101542 GeneCards: USP15
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252078
NM_001252079
NM_006313

NM_001301628
NM_027604

RefSeq (protein)

NP_001288557
NP_081880

Location (UCSC)n/a Chr 10: 122.94 – 123.03 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene. [4] [5]

Ubiquitin is a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). [5]

See also

Related Research Articles

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Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.

<span class="mw-page-title-main">USP8</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.

<span class="mw-page-title-main">USP6</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 6 (USB6), also termed TRE17 and Tre-2, is a deubiquitinating enzyme that in humans is encoded by the hominid USP6 gene located at band 13.2 on the short arm of chromosome 17. Deubiquitinating enzymes (DUBs) are enzymes that act within cells to remove ubiquitins from various functionally important proteins. Ubiquitin enzymes add ubiquitin to these proteins and thereby regulate their cellular location, alter their activity, and/or promote their degradation. By deubiquitinating these proteins, DUBs counter the effects of the ubiquinating enzymes and contribute to regulating the actions of the targeted proteins. In normal adult tissues, USP6 is highly expressed in testicle tissue, modestly expressed in ovarian tissue, and absent or minimally expressed in other tissues. It is also highly expressed in fetal brain tissue. The specific functions of USP6 are poorly defined primarily because its presence is restricted to primates: there are no available animal models to determine the effects of its deletion, although some studies suggest that UPSP6 contributes to normal brain development. In all events, USP6 has gained wide interest because of its abnormally increased expression by the neoplastic cells in various tumors derived from mesenchymal tissue.

<span class="mw-page-title-main">USP10</span> Protein-coding gene in the species Homo sapiens

Ubiquitin specific peptidase 10, also known as USP10, is an enzyme which in humans is encoded by the USP10 gene.

<span class="mw-page-title-main">USP16</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.

<span class="mw-page-title-main">USP4</span>

Ubiquitin specific protease 4 (USP4) is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the standardization of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mammals. In the mouse and human the USP4 protein is encoded by a gene containing 22 exons.

<span class="mw-page-title-main">USP11</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase or Ubiquitin specific protease 11 is an enzyme that in humans is encoded by the USP11 gene. USP11 belongs to the Ubiquitin specific proteases family (USPs) which is a sub-family of the Deubiquitinating enzymes (DUBs).USPs are multiple domain proteases and belong to the C19 cysteine proteases sub‒family. Depending on their domain architecture and position there is different homology between the various members. Generally the largest domain is the catalytic domain which harbours the three residue catalytic triad that is included inside conserved motifs. The catalytic domain also contains sequences that are not related with the catalysis function and their role is mostly not clearly understood at present, the length of these sequences varies for each USP and therefore the length of the whole catalytic domain can range from approximately 295 to 850 amino acids. Particular sequences inside the catalytic domain or at the N‒terminus of some USPs have been characterised as UBL and DUSP domains respectively. In some cases, regarding the UBL domains, it has been reported to have a catalysis enhancing function as in the case of USP7. In addition, a so‒called DU domain module is the combination of a DUSP domain followed by a UBL domain separated by a linker and is found in USP11 as well as in USP15 and USP4.

<span class="mw-page-title-main">USP36</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene.

<span class="mw-page-title-main">SENP2</span> Protein-coding gene in the species Homo sapiens

Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.

<span class="mw-page-title-main">USP1</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.

<span class="mw-page-title-main">USP37</span> Protein-coding gene in the species Homo sapiens

Ubiquitin specific processing protease 37 is an enzyme that in humans, is encoded by the USP37 gene.

<span class="mw-page-title-main">USP33</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.

<span class="mw-page-title-main">USP48</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 48 is an enzyme that in humans is encoded by the USP48 gene.

<span class="mw-page-title-main">USP2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.

<span class="mw-page-title-main">BIRC6</span> Protein-coding gene in the species Homo sapiens

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.

<span class="mw-page-title-main">USP13</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene.

<span class="mw-page-title-main">USP14</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.

<span class="mw-page-title-main">USP20</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 20 is an enzyme that in humans is encoded by the USP20 gene.

<span class="mw-page-title-main">USP40</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 40 is an enzyme that in humans is encoded by the USP40 gene.

<span class="mw-page-title-main">USP34</span> Protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020124 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID   12838346. S2CID   2856065.
  5. 1 2 "Entrez Gene: USP15 ubiquitin specific peptidase 15".

Further reading