USS Edisto may refer to:
- USS Edisto (CVE-41) was a Bogue-class escort carrier transferred to the Royal Navy as HMS Nabob
- USS Edisto (AGB-2) was a Wind-class icebreaker transferred to the United States Coast Guard as USCGC Edisto (WAGB-284) and decommissioned in 1974
- USCGC Edisto (WPB-1313) is an Island-class patrol boat currently in service with the United States Coast Guard
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.