UTY (gene)

UTY
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3ZLI, 3ZPO, 4UF0, 5FY0, 5FXW, 5FXX, 5FXZ, 5FY1, 5FY7, 5FYM, 5FXV, 5A1L
Identifiers
Aliases	UTY , KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C
External IDs	OMIM: 400009; GeneCards: UTY; OMA:UTY - orthologs
Gene location (Human) Chr. Y chromosome (human) [1] Band Yq11.221 Start 13,234,577 bp [1] End 13,480,673 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad corpus callosum testicle tendon of biceps brachii rectum right lung prostate cartilage tissue corpus epididymis middle frontal gyrus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity dioxygenase activity histone H3-tri/di-methyl-lysine-27 demethylase activity metal ion binding histone demethylase activity RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding chromatin DNA binding sequence-specific DNA binding Cellular component nucleus nucleoplasm MLL3/4 complex Biological process regulation of gene expression histone H3-K27 demethylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7404 n/a Ensembl ENSG00000183878 n/a UniProt O14607 n/a RefSeq (mRNA) NM_001258249 NM_001258250 NM_001258251 NM_001258252 NM_001258253 NM_001258254 NM_001258255 NM_001258256 NM_001258257 NM_001258258 NM_001258259 NM_001258260 NM_001258261 NM_001258262 NM_001258263 NM_001258264 NM_001258265 NM_001258266 NM_001258267 NM_001258268 NM_001258269 NM_001258270 NM_007125 NM_182659 NM_182660 NM_001400170 NM_001400171 NM_001400173 NM_001400175 NM_001400177 NM_001400178 NM_001400181 NM_001400183 NM_001400185 NM_001400187 NM_001400189 NM_001400192 NM_001400195 NM_001400199 n/a RefSeq (protein) NP_001245178 NP_001245179 NP_001245180 NP_001245181 NP_001245182 NP_001245183 NP_001245184 NP_001245185 NP_001245186 NP_001245187 NP_001245188 NP_001245189 NP_001245190 NP_001245191 NP_001245192 NP_001245193 NP_001245194 NP_001245195 NP_001245196 NP_001245197 NP_001245198 NP_001245199 NP_009056 NP_872600 NP_872601 NP_001245196.1 NP_001245192.1 NP_001245178.1 NP_001245194.1 NP_001245186.1 NP_001245191.1 NP_001245187.1 n/a Location (UCSC) Chr Y: 13.23 – 13.48 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Histone demethylase UTY, or Ubiquitously transcribed tetratricopeptide repeat, Y chromosome, is an enzyme that in humans is encoded by the UTY gene. ^{[3] [4] [5]}

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms. ^[5]

The X-chromosome version of this gene is called UTX.

Interactions

UTY has been shown to interact with TLE1 ^[6] and WDR90. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000183878 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (December 1996). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nature Genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID   8944031. S2CID   9994966.
4. Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (April 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi: 10.1093/hmg/7.4.737 . PMID   9499428.
5. "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
6. Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC   1219929 . PMID   9854018.
7. "STRING: functional protein association networks". string-db.org. Archived from the original on 2013-05-15. Retrieved 2015-05-07.

Further reading

• Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID   9381176.
• Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (January 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC   1219929 . PMID   9854018.
• Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, et al. (March 2000). "The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen". Journal of Immunology. 164 (5): 2807–14. doi: 10.4049/jimmunol.164.5.2807 . PMID   10679124.
• Foresta C, Ferlin A, Moro E (May 2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Human Molecular Genetics. 9 (8): 1161–9. doi:10.1093/hmg/9.8.1161. PMID   10767340.
• Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, et al. (June 2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7354–9. Bibcode:2000PNAS...97.7354S. doi: 10.1073/pnas.97.13.7354 . PMC   16549 . PMID   10861003.
• Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH (November 2000). "UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition". Blood. 96 (9): 3126–32. doi:10.1182/blood.V96.9.3126. PMID   11049993.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Agate RJ, Choe M, Arnold AP (February 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96. doi: 10.1093/molbev/msh027 . PMID   14660691.
• Gerrard DT, Filatov DA (June 2005). "Positive and negative selection on mammalian Y chromosomes". Molecular Biology and Evolution. 22 (6): 1423–32. doi: 10.1093/molbev/msi128 . PMID   15758204.