Uche Veronica Amazigo is a professor of Medical Parasitology and public health specialist. She is a fellow of the Nigerian Academy of Science who was elected into the Academy's Fellowship at its Annual General Meeting held in January 2015. [1] In 2012, she won the Prince Mahidol Award for outstanding contributions to public health. [2] She is best known for her research on onchocerciasis and her consequent contributions to the World Health Organization (WHO). [3]
Uche Veronica Amazigo (née Onubogu) is a biologist, who is trained in public health, parasitology and specializes in tropical diseases. [4] She is from Enugu, Nigeria. [5] She went to the University of Vienna in Austria, where she received her Ph.D. in Biology and Medical Parasitology. [6] She also holds a Diploma in Tropical Medicine and Parasitology from the Bernhard-Nocht Institute of Tropical Medicine in Hamburg, Germany and Fellowship in International Health from the Harvard T.H. Chan School of Public Health. [6] She also was awarded an honorary Doctor of Science degree from the University of KwaZulu-Natal in South Africa in 2013. [5] [7]
In her early career, Amazigo was a senior lecturer at the University of Nigeria in Nsukka, where she taught medical parasitology and public health. [8] It was during this period in the late 1970s that she began studying onchocerciasis (river blindness) after encountering the disease during her travels around the area. [3] She joined a rural women's support group in order to better study the social effects that the disease had on rural communities. [3] She then applied for and received a research grant from the United Nations’ Special Programme for Research and Training in Tropical Diseases (TDR) in order to continue her research into river blindness. [3] She then worked for the TDR for several years, where she developed a program for training community workers to treat themselves and others, and keep record books of the treatments. [9] She brought her findings to the WHO, where her studies were replicated. [9] The results from this replication resulted in the founding of the African Programme for Onchocerciasis Control (APOC) in 1995. [9] Amazigo joined the APOC as a scientist in 1996. [3] Her work with the APOC built upon her work with the TDR, and resulted in the development of Community-Directed Treatment with Ivermectin (CDTI), with ivermectin being the drug that treats onchocerciasis. [10] It is estimated that her CDTI strategy has resulted in the treatment of over 112.4 million people for onchocerciasis, 11 million people for malaria control, and 37 million people for the control of other diseases. [11] [12] Amazigo spent four years as the Chief of the WHO's sustainable drug distribution unit from 2001–2005. [9] She served as the director of the APOC from 2005 until 2011. [10] During this period, she engaged 16 African governments, 14 international non-governmental organizations (NGOs), 20 bilateral and multi-lateral donors, and pharmaceutical companies. [4] After retiring from the APOC, she founded the Pan-African Community Initiative on Education and Health (PACIEH) in 2013. [13]
While serving as a WHO Officer, she received the distinction of being named a Knight of the National Order of Burkina Faso. [4] She was also recognized by the US Agency for International Development and the National Medical Research Institute of Tanzania and received the Dr Jean Mayer Global Citizenship Award from Tufts University. [4] Also, with her as Director, the APOC was awarded the 1 million Euro António Champalimaud Vision Award in 2011, which is the biggest global award for outstanding contributions to the prevention of visual impairment and blindness. [12] She was a member of multiple organizations such as the Board of Trustees of Sightsavers, the TY Danjuma Foundation, Advisory Board of Massachusetts General Hospital Center for Global Health, and Merck's Global Advisory Board on Maternal Mortality. [4]
Amazigo has more than 55 publications in international peer-reviewed journals. [4]
Amazigo, U. (October 1993). "Onchocerciasis and women's reproductive health: indigenous and biomedical concepts". Tropical Doctor. 23 (4): 149–151. doi:10.1177/004947559302300404. ISSN 0049-4755. PMID 8273155. S2CID 38022678.
Amazigo, Uche; Okeibunor, Joseph; Matovu, Victoria; Zouré, Honorat; Bump, Jesse; Seketeli, Azodoga (2007). "Performance of predictors: Evaluating sustainability in community-directed treatment projects of the African programme for onchocerciasis control". Social Science & Medicine. 64 (10): 2070–2082. doi:10.1016/j.socscimed.2007.01.018. PMID 17383061.
Loa loa filariasis is a skin and eye disease caused by the nematode worm Loa loa. Humans contract this disease through the bite of a deer fly or mango fly, the vectors for Loa loa. The adult Loa loa filarial worm migrates throughout the subcutaneous tissues of humans, occasionally crossing into subconjunctival tissues of the eye where it can be easily observed. Loa loa does not normally affect one's vision but can be painful when moving about the eyeball or across the bridge of the nose. The disease can cause red itchy swellings below the skin called "Calabar swellings". The disease is treated with the drug diethylcarbamazine (DEC), and when appropriate, surgical methods may be employed to remove adult worms from the conjunctiva. Loiasis belongs to the so-called neglected diseases.
Loa loa is a filarial (arthropod-borne) nematode (roundworm) that causes Loa loa filariasis. Loa loa actually means "worm worm", but is commonly known as the "eye worm", as it localizes to the conjunctiva of the eye. Loa loa is commonly found in Africa. It mainly inhabits rain forests in West Africa and has native origins in Ethiopia. The disease caused by Loa loa is called loiasis and is one of the neglected tropical diseases.
Onchocerciasis, also known as river blindness, is a disease caused by infection with the parasitic worm Onchocerca volvulus. Symptoms include severe itching, bumps under the skin, and blindness. It is the second-most common cause of blindness due to infection, after trachoma.
Filariasis is a parasitic disease caused by an infection with roundworms of the Filarioidea type. These are spread by blood-feeding insects such as black flies and mosquitoes. They belong to the group of diseases called helminthiases.
Tropical diseases are diseases that are prevalent in or unique to tropical and subtropical regions. The diseases are less prevalent in temperate climates, due in part to the occurrence of a cold season, which controls the insect population by forcing hibernation. However, many were present in northern Europe and northern America in the 17th and 18th centuries before modern understanding of disease causation. The initial impetus for tropical medicine was to protect the health of colonial settlers, notably in India under the British Raj. Insects such as mosquitoes and flies are by far the most common disease carrier, or vector. These insects may carry a parasite, bacterium or virus that is infectious to humans and animals. Most often disease is transmitted by an insect bite, which causes transmission of the infectious agent through subcutaneous blood exchange. Vaccines are not available for most of the diseases listed here, and many do not have cures.
Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, today it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken orally, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
Onchocerca volvulus is a filarial (arthropod-borne) nematode (roundworm) that causes onchocerciasis, and is the second-leading cause of blindness due to infection worldwide after trachoma. It is one of the 20 neglected tropical diseases listed by the World Health Organization, with elimination from certain countries expected by 2020.
Neglected tropical diseases (NTDs) are a diverse group of tropical infections that are common in low-income populations in developing regions of Africa, Asia, and the Americas. They are caused by a variety of pathogens, such as viruses, bacteria, protozoa, and parasitic worms (helminths). These diseases are contrasted with the "big three" infectious diseases, which generally receive greater treatment and research funding. In sub-Saharan Africa, the effect of neglected tropical diseases as a group is comparable to that of malaria and tuberculosis. NTD co-infection can also make HIV/AIDS and tuberculosis more deadly.
Eradication is the reduction of an infectious disease's prevalence in the global host population to zero.
United Front Against Riverblindness (UFAR) is a Non-Governmental Development Organization (NGDO) that provides technical, managerial and financial support for the elimination of riverblindness, or onchocerciasis, in the Kasongo region of Maniema province in the east-southern region of the Democratic Republic of the Congo (DRC).
Sightsavers is an international non-governmental organisation that works with partners in developing countries to treat and prevent avoidable blindness, and promote equality for people with visual impairments and other disabilities. It is based in Haywards Heath in the United Kingdom, with branches in Sweden, Norway, India, Italy, Republic of Ireland, the United Arab Emirates, and the US.
Adetokunbo Oluwole Lucas was a Nigerian doctor who was considered a global leader in tropical diseases. Born in Lagos, he was educated in the United Kingdom and commenced his professional career in Nigeria. Lucas received the Prince Mahidol Award in 1999 for his support of strategic research on the tropical diseases. He served for ten years as the Director of Special Programmes for Research and Training in Tropical Diseases based at the World Health Organization in Geneva, Switzerland. He was Adjunct Professor of International Health Department of Global Health and Population of the Harvard School of Public Health. Lucas worked largely during his life time in his home nation of Nigeria and traveled frequently to the United Kingdom and to the Harvard School of Public Health in the United States.
The London Declaration on Neglected Tropical Diseases was a collaborative disease eradication programme launched on 30 January 2012 in London. It was inspired by the World Health Organization roadmap to eradicate or prevent transmission for neglected tropical diseases by the year 2020. Officials from WHO, the World Bank, the Bill & Melinda Gates Foundation, the world's 13 leading pharmaceutical companies, and government representatives from US, UK, United Arab Emirates, Bangladesh, Brazil, Mozambique and Tanzania participated in a joint meeting at the Royal College of Physicians to launch this project. The meeting was spearheaded by Margaret Chan, Director-General of WHO, and Bill Gates, Co-Chair of the Bill & Melinda Gates Foundation.
William Cecil Campbell is an Irish biologist and parasitologist with United States citizenship, known for his work in discovering a novel therapy against infections caused by roundworms, for which he was jointly awarded the 2015 Nobel Prize in Physiology or Medicine. He helped to discover a class of drugs called avermectins, whose derivatives have been shown to have "extraordinary efficacy" in treating River blindness and Lymphatic filariasis, among other parasitic diseases affecting animals and humans. Campbell worked at the Merck Institute for Therapeutic Research 1957–1990, and is currently a research fellow emeritus at Drew University.
Ekanem Ikpi Braide (OFR) is a Nigerian Parasitologist. She was a Vice-Chancellor of Cross River University of Technology (CRUTECH), Calabar, and pioneer Vice-Chancellor of Federal University of Technology, Lafia. She is credited with a major contribution to the eradication of guinea worm in Nigeria. In 2020, she was made the first female President-elect of the Nigerian Academy of Science. Braide is Chairman of the Board of Trustees, The Leprosy Mission (TLM) Nigeria. She is the Pro-Chancellor of Arthur Jarvis University, Akpabuyo, Nigeria. She is the first female President of the Nigerian Academy of Science.
Celestine Onyemobi Elihe Onwuliri was a renowned university professor of Parasitology and 5th substantive Vice Chancellor of the FUTO University. He was also the Ag. Vice Chancellor of the University of Jos and a two-time Honorable Commissioner. After his death, an educational institution of higher learning in the US, the Graduate Theological Foundation instituted a fellowship in his honour called the Celestine O. E. Onwuliri Fellowship in Scientific Research and Human Values.
Dr. Winnie Mpanju-Shumbusho is a Tanzanian-born paediatrician and public health leader who until December 31, 2015, served as World Health Organization (WHO) Assistant Director General for HIV/AIDS, Tuberculosis, Malaria and Neglected Tropical Diseases based in Geneva, Switzerland. From 2016 to 2019, she served as board chair of RBM Partnership To End Malaria. Before joining WHO in 1999, Mpanju-Shumbusho was Director General of The East, Central and Southern African Health Community (ECSA-HC) formerly known as the Commonwealth Regional Health Community for East, Central and Southern Africa (CRHC-ECSA). Mpanju-Shumbusho is a co-founder, board member, and volunteer for the not-for-profit organization Adventures in Health, Education, and Agricultural Development, which was founded in 1981 to provide hands-on, people-to-people assistance to underserved communities in Africa and inner-city United States. She was also co-founder of the Medical Women Association of Tanzania and served as Treasurer and executive committee member of the Medical Association of Tanzania. In 2019, she was awarded the Multisector Partnership Honour by Malaria No More as one of the top Women Leading the Fight Against Malaria. Mpanju-Shumbusho is married with two adult children.
Professor Ikechukwu Nosike Simplicius Dozie is a professor of Microbiology, a public health scientist, teacher and community health specialist currently serving at the Department of Public Health, Federal University of Technology Owerri, Nigeria. He is a member of American Society of Tropical Medicine & Hygiene (ASTMH). Dozie was a consultant to the World Health Organisation; WHO’s African programme for Onchocerciasis. He is the Director, Linkages and Advancement, Federal University of Technology Owerri.
Chinyere Ukaga is a professor of public health parasitology in the department of Animal and Environmental Biology, Imo State University, Owerri.
Christian Happi is a Professor of Molecular Biology and Genomics in the Department of Biological Sciences and the Director of African Centre of Excellence for Genomics of Infectious Diseases, both at Redeemer’s University. He is known for leading the team of scientists that used genomic sequencing to identify a single point of infection from an animal reservoir to a human in the Ebola outbreak in West Africa. His research focus is on infectious diseases, including malaria, Lassa fever, Ebola virus disease, HIV and SARS-CoV-2.