Val Murray Runge

Last updated
Val M. Runge
Runge figure garmish.jpg
Born (1956-08-28) August 28, 1956 (age 67)
Austin, Texas
Nationality American
Alma mater Stanford University, Stanford University School of Medicine, Vanderbilt University Medical Center, University of Bern
Scientific career
Fields Radiology
Institutions University of Bern

Val Murray Runge (born August 28, 1956, in Austin, Texas) is an American and Swiss professor of radiology and the editor-in-chief of Investigative Radiology . [1] Runge was one of the early researchers to investigate the use of gadolinium-based contrast agents for magnetic resonance imaging (MRI), [2] giving the first presentation in this field (in 1982), [3] followed two years later by the first presentation of efficacy (in 1984). [4] His research also pioneered many early innovations in MRI, including the use of tilted planes (for standardization of brain imaging, in 1987) and respiratory gating (for liver imaging, in 1984). [5] [6] His publication on multiple sclerosis in 1984 represented the third and largest clinical series (to that date) investigating the role of MRI in this disease, and the first to show characteristic abnormalities on MRI in patients whose CT was negative. [7]

Contents

Biography

Runge was born in Austin, Texas and graduated from Stanford University with a Bachelor of Science, with honors, in Chemistry in June 1978. He subsequently received his MD from Stanford University School of Medicine in January 1982. Following completion of a diagnostic radiology residency at Vanderbilt University Medical Center in December 1985, Runge was appointed as assistant professor and chief of service of magnetic resonance at Tufts University School of Medicine in 1986. He was promoted to associate professor in 1988. In 1990 he was appointed professor of diagnostic radiology and biomedical engineering, Director of the Magnetic Resonance Imaging and Spectroscopy Center, and the Rosenbaum Endowed Chair of Diagnostic Radiology, at the University of Kentucky Medical Center. In 2002, Runge was appointed the Robert and Alma Moreton Centennial Chair in Radiology, Scott & White Memorial Hospital, and professor of radiology at the Texas A&M Health Science Center. In 2010 he was appointed the John Sealy Distinguished Chair and professor of radiology at the University of Texas Medical Branch in Galveston. In 2011, he received an additional honorary appointment as visiting professor, for 2012–2015, from Tongji Medical College, Wuhan, Central China. Runge then spent two years in Zurich, Switzerland as a visiting professor at the University Hospital of Zürich (2013-2015). Runge lives currently in Zurich, Switzerland, having a long-term appointment (2015-present) as a member of the faculty at Inselspital, Universitätsspital Bern. He received the title of Prof. Dr. med. from the University of Bern in 2019.

Scientific career

Runge is an early pioneer in MRI, known for his work in 1982-1984 demonstrating for the first time the potential as well as early diagnostic utility of intravenous contrast media in MRI, specifically the gadolinium chelates. [5] [8] [9] [10]

He is an author of more than 230 peer-reviewed papers published in the scientific literature. He is also the editor for twenty-one medical textbooks, [11] [12] [13] [14] [15] [16] [17] with several of these translated into other languages, including German, [18] [19] Chinese, Polish and Turkish. His most recent textbooks are "Neuroradiology - the Essentials with MR and CT", second edition, [20] "Imaging of Cerebrovascular Disease", [21] "The Physics of Clinical MR Taught Through Images", fifth edition (2022), [22] and the second edition of "Essentials of Clinical MR". [23] He has given more than 800 scientific and invited presentations at national and international meetings and medical schools across North America, Europe, Australia, Japan, Korea and China over the past 38 years.

Runge holds a U.S. patent (#4615879), together with Jeffrey A. Clanton, for oral particulate NMR contrast agents. [24]

Current activities

Since 1994, Runge has been editor-in-chief of Investigative Radiology (2022 Impact Factor of 6.7). He was also a member of the editorial boards of the Journal of Magnetic Resonance Imaging and Topics in Magnetic Resonance Imaging since their respective inceptions, in 1991 and 1988, and remained on these two editorial boards until the early 2020s. He remains active in research and development of MRI contrast agents and advanced MRI imaging techniques. In 2019, under his guidance, the first study demonstrating the toxicity of gadolinium chelates to brain tissue was published. [25] This identifies a pathway by which linear gadolinium chelates may produce ill effects in otherwise normal patients long after injection, supporting the EMA's decision in 2017 to withdraw certain, and restrict other, agents in this category from clinical use. Runge also maintains an educational website (clinical-mri.com), for which international experts in MRI provide insights on imaging techniques and strategies.

Awards and membership

He was elected Fellow of the International Society for Magnetic Resonance in Medicine in 1990. In 2011, Runge received the Harry Fisher Medal for Excellence in Contrast Media Research from the Contrast Media Research Society. [26]

Other academic honors include the Executive Council Award from the American Roentgen Ray Society (for research in MRI and multiple sclerosis), [27] the Dyke Memorial Award from the American Society of Neuroradiology (for MR contrast media research), [28] and a Magna Cum Laude Award (for the best scientific exhibit) from the Radiological Society of North America. [29] He is a diplomate of the American Board of Radiology (1986).

Private life

Runge has two daughters and currently resides in Zurich, Switzerland.

Related Research Articles

<span class="mw-page-title-main">Gadolinium</span> Chemical element, symbol Gd and atomic number 64

Gadolinium is a chemical element; it has symbol Gd and atomic number 64. Gadolinium is a silvery-white metal when oxidation is removed. It is a malleable and ductile rare-earth element. Gadolinium reacts with atmospheric oxygen or moisture slowly to form a black coating. Gadolinium below its Curie point of 20 °C (68 °F) is ferromagnetic, with an attraction to a magnetic field higher than that of nickel. Above this temperature it is the most paramagnetic element. It is found in nature only in an oxidized form. When separated, it usually has impurities of the other rare-earths because of their similar chemical properties.

<span class="mw-page-title-main">Magnetic resonance imaging</span> Medical imaging technique

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy.

A contrast agent is a substance used to increase the contrast of structures or fluids within the body in medical imaging. Contrast agents absorb or alter external electromagnetism or ultrasound, which is different from radiopharmaceuticals, which emit radiation themselves. In x-ray imaging, contrast agents enhance the radiodensity in a target tissue or structure. In magnetic resonance imaging, contrast agents shorten the relaxation times of nuclei within body tissues in order to alter the contrast in the image.

<span class="mw-page-title-main">Gadopentetic acid</span> Complex of gadolinium by DTPA

Gadopentetic acid, sold under the brand name Magnevist, is a gadolinium-based MRI contrast agent.

<span class="mw-page-title-main">Gadolinium(III) oxide</span> Chemical compound

Gadolinium(III) oxide (archaically gadolinia) is an inorganic compound with the formula Gd2O3. It is one of the most commonly available forms of the rare-earth element gadolinium, derivatives of which are potential contrast agents for magnetic resonance imaging.

<span class="mw-page-title-main">Breast MRI</span> Form of breast imaging

One alternative to mammography, breast MRI or contrast-enhanced magnetic resonance imaging (MRI), has shown substantial progress in the detection of breast cancer.

<span class="mw-page-title-main">Gadodiamide</span> Chemical compound

Gadodiamide, sold under the brand name Omniscan, is a gadolinium-based MRI contrast agent (GBCA), used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.

Nephrogenic systemic fibrosis is a rare syndrome that involves fibrosis of the skin, joints, eyes, and internal organs. NSF is caused by exposure to gadolinium in gadolinium-based MRI contrast agents (GBCAs) in patients with impaired kidney function. Epidemiological studies suggest that the incidence of NSF is unrelated to gender or ethnicity and it is not thought to have a genetic basis. After GBCAs were identified as a cause of the disorder in 2006, and screening and prevention measures put in place, it is now considered rare.

MRI contrast agents are contrast agents used to improve the visibility of internal body structures in magnetic resonance imaging (MRI). The most commonly used compounds for contrast enhancement are gadolinium-based contrast agents (GBCAs). Such MRI contrast agents shorten the relaxation times of nuclei within body tissues following oral or intravenous administration.

<span class="mw-page-title-main">Cardiac magnetic resonance imaging</span>

Cardiac magnetic resonance imaging, also known as cardiovascular MRI, is a magnetic resonance imaging (MRI) technology used for non-invasive assessment of the function and structure of the cardiovascular system. Conditions in which it is performed include congenital heart disease, cardiomyopathies and valvular heart disease, diseases of the aorta such as dissection, aneurysm and coarctation, coronary heart disease. It can also be used to look at pulmonary veins. Patient information may be found here.

<span class="mw-page-title-main">Gadobutrol</span> Chemical compound

Gadobutrol (INN) (Gd-DO3A-butrol) is a gadolinium-based MRI contrast agent (GBCA).

<span class="mw-page-title-main">Gadoteric acid</span> Chemical compound

Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd3+), and is used in form of the meglumine salt (gadoterate meglumine). The paramagnetic property of gadoteric acid reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in MRI, which is the source of its clinical utility. Because it has magnetic properties, gadoteric acid develops a magnetic moment when put under a magnetic field, which increases the signal intensity (brightness) of tissues during MRI imaging.

Burton Drayer, MD, FACR, FANN, is an American radiologist and nationally recognized authority on the use of computed tomography and magnetic resonance imaging for diagnosing neurological disorders. From 2003 to 2008, he served as president, The Mount Sinai Hospital. As of 2020, he is the Charles M. and Marilyn Newman Professor and System Chair, Radiology, for The Mount Sinai Health System and Icahn School of Medicine at Mount Sinai Hospital in New York City.

<span class="mw-page-title-main">Cardiac magnetic resonance imaging perfusion</span>

Cardiac magnetic resonance imaging perfusion, also known as stress CMR perfusion, is a clinical magnetic resonance imaging test performed on patients with known or suspected coronary artery disease to determine if there are perfusion defects in the myocardium of the left ventricle that are caused by narrowing of one or more of the coronary arteries.

<span class="mw-page-title-main">Perfusion MRI</span>

Perfusion MRI or perfusion-weighted imaging (PWI) is perfusion scanning by the use of a particular MRI sequence. The acquired data are then post-processed to obtain perfusion maps with different parameters, such as BV, BF, MTT and TTP.

Synthetic MRI is a simulation method in Magnetic Resonance Imaging (MRI), for generating contrast weighted images based on measurement of tissue properties. The synthetic (simulated) images are generated after an MR study, from parametric maps of tissue properties. It is thereby possible to generate several contrast weightings from the same acquisition. This is different from conventional MRI, where the signal acquired from the tissue is used to generate an image directly, often generating only one contrast weighting per acquisition. The synthetic images are similar in appearance to those normally acquired with an MRI scanner.

<span class="mw-page-title-main">Medical imaging in pregnancy</span> Types of pregnancy imaging techniques

Medical imaging in pregnancy may be indicated because of pregnancy complications, intercurrent diseases or routine prenatal care.

<span class="mw-page-title-main">MRI sequence</span>

An MRI sequence in magnetic resonance imaging (MRI) is a particular setting of pulse sequences and pulsed field gradients, resulting in a particular image appearance.

Magnetic resonance myelography is a noninvasive medical imaging technique that can provide anatomic information about the subarachnoid space. It is a type of MRI examination that uses a contrast medium and magnetic resonance imaging scanner to detect pathology of the spinal cord, including the location of a spinal cord injury, cysts, tumors and other abnormalities. The procedure involves the injection of a gadolinium based contrast media into the cervical or lumbar spine, followed by the MRI scan.

<span class="mw-page-title-main">Gadopiclenol</span> MRI contrast agent

Gadopiclenol, sold under the brand name Elucirem among others, is a contrast agent used with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and in the body. Gadopiclenol is a paramagnetic macrocyclic non-ionic complex of gadolinium.

References

  1. ↑ "Editorial Board". Investigative Radiology. Lippincott Williams & Wilkins . Retrieved 2013-10-13.
  2. ↑ Runge VM, Schoerner W, Niendorf HP, Laniado M, Koehler D, Claussen C, Felix R, James AE; Schoerner; Niendorf; Laniado; Koehler; Claussen; Felix; James Jr (1985). "Initial clinical evaluation of gadolinium DTPA for contrast-enhanced magnetic resonance imaging". Magnetic Resonance Imaging . 3 (1): 27–35. doi:10.1016/0730-725x(85)90006-2. PMID   2987640.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ↑ Runge VM, Stewart RG, Clanton JA, James AE, Partain CL. Paramagnetic NMR contrast agents: Potential oral and intravenous agents. Work-in-progress, Radiological Society of North America, November 1982.
  4. ↑ Runge VM, Clanton JA, Price AC, Herzer WA, Allen JH, Partain CL, James AE: Contrast enhanced magnetic resonance evaluation of a brain abscess model. 1984 Cornelius G. Dyke Memorial Award. 22nd Annual Meeting of the American Society of Neuroradiology, June 1984. American Journal of Neuroradiology 1984; 5:677.
  5. 1 2 Runge VM, Osborne MA, Wood ML, Wolpert SM, Kwan E, Kaufman DM (1987). "The efficacy of tilted axial MRI of the CNS". Magnetic Resonance Imaging . 5 (6): 421–30. doi:10.1016/0730-725X(87)90376-6. PMID   3431352.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ↑ Runge VM, Clanton JA, Partain CL, James AE Jr. (1984). "Respiratory gating in magnetic resonance imaging at 0.5 Tesla". Radiology . 151 (2): 521–3. doi:10.1148/radiology.151.2.6709928. PMID   6709928.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ↑ Runge VM, Clanton JA, Partain CL, James AE Jr. (1984). "Magnetic resonance imaging of multiple sclerosis: a study of pulse-technique efficacy". American Journal of Roentgenology . 143 (5): 1015–26. doi:10.2214/ajr.143.5.1015. PMID   6333143.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ↑ Runge VM, Clanton JA, Price AC, Wehr CJ, Herzer WA, Partain CL, James AE; Clanton; Price; Wehr; Herzer; Partain; James Jr (1985). "The use of Gd DTPA as a perfusion agent and marker of blood-brain barrier disruption". Magnetic Resonance Imaging . 3 (1): 43–55. doi:10.1016/0730-725x(85)90008-6. PMID   3923292.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ↑ Runge VM, Clanton JA, Foster MA, Smith FW, Lukehart CM, Jones MM, Partain CL, James AE; Clanton; Foster; Smith; Lukehart; Jones; Partain; James Jr (1984). "Paramagnetic NMR contrast agents. Development and evaluation". Investigative Radiology . 19 (5): 408–15. doi:10.1097/00004424-198409000-00013. PMID   6439672.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. ↑ Runge VM, Clanton JA, Herzer WA, Gibbs SJ, Price AC, Partain CL, James AE; Clanton; Herzer; Gibbs; Price; Partain; James Jr (October 1984). "Intravascular contrast agents suitable for magnetic resonance imaging". Radiology . 153 (1): 171–6. doi:10.1148/radiology.153.1.6433402. PMID   6433402.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ↑ "Clinical MRI / Edition 1 by Val M. Runge | 9780721680361 | Hardcover | Barnes & Noble". Search.barnesandnoble.com. Retrieved 2013-10-13.
  12. ↑ Thieme Medical Publishers | The Physics of Clinical MR Taught Through Images. Thieme.com. 2018. ISBN   9781626234277 . Retrieved 2013-10-13.
  13. ↑ "Thieme Medical Publishers | The Cerefy Atlas of Cerebral Vasculature/CD-ROM". Thieme.com. Retrieved 2013-10-13.
  14. ↑ "Thieme Medical Publishers | Essentials of Clinical MR". Thieme.com. Retrieved 2013-10-13.
  15. ↑ "Thieme Medical Publishers | Clinical 3T Magnetic Resonance". Thieme.com. Retrieved 2013-10-13.
  16. ↑ Runge, Val M (1992). Magnetic resonance imaging: Clinical principles. Lippincott. ISBN   9780397510955.
  17. ↑ Runge, Val M (1994). Magnetic Resonance Imaging of the Brain. Lippincott. ISBN   9780397512447.
  18. ↑ "Praxiskurs MRT - Thieme.de - Thieme Webshop" (in German). Thieme.de. Retrieved 2013-10-13.
  19. ↑ "Essentials der klinischen MRT - Thieme.de - Thieme Webshop" (in German). Thieme.de. Retrieved 2013-10-13.
  20. ↑ Runge, Val M.; Smoker, Wendy R. K.; Valavanis, Anton (11 December 2014). Neuroradiology. Thieme. ISBN   9781604069167.
  21. ↑ Runge, Val M. (2016). Imaging of Cerebrovascular Disease. Thieme. ISBN   9781626232488.
  22. ↑ Runge, Val M.; Nitz, Wolfgang R.; Heverhagen, Johannes T. (2018). The Physics of Clinical MR Taught Through Images. Thieme. ISBN   9781626234277.
  23. ↑ Essentials of Clinical MR, 2nd edition.
  24. ↑ "Patent US4615879 - Particulate NMR contrast agents for gastrointestinal application - Google Patents" . Retrieved 2013-10-13.
  25. ↑ Bower DV, Richter JK, von Tengg-Kobligk H, Heverhagen JT, Runge VM (2019). "Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases with Reduced Kinetic Stability of the Agent" (PDF). Investigative Radiology . 54 (8): 453–463. doi: 10.1097/RLI.0000000000000567 . PMID   31265439.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  26. ↑ "Shining Stars | Impact Newsletter: November 1, 2011 | UTMB". Utmb.edu. 2011-11-01. Retrieved 2013-10-13.
  27. ↑ Runge VM, Price AC, Kirschner HS, Allen JH, Partain CL, James AE Jr. The evaluation of multiple sclerosis by magnetic resonance imaging. Presented at the 84th Annual Meeting of the American Roentgen Ray Society, April 1984. Executive Council Award.
  28. ↑ "ASNR's Cornelius G. Dyke Memorial Award". ASNR. Retrieved 2013-10-13.
  29. ↑ Runge VM, Clanton JA, Price AC, Herzer WA, Wehr CJ, Schoerner VW, Felix R, Partain CL, James AE. Contrast enhanced magnetic resonance imaging of the brain: experimental and clinical investigation with Gd DTPA. 70th Annual Meeting of the Radiological Society of North America. Radiology 1984; 153:343.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.