Vertical occipital fasciculus

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The vertical occipital fasciculus is a fascicle of white matter running vertically in the rear of the brain. It is found at least in primates. It "is the only major fiber bundle connecting dorsolateral and ventrolateral visual cortex." [1]

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Vertical occipital fasciculus
Vertical Occipital Fasciculus.jpg
Anatomical terms of neuroanatomy

Early discovery

Originally depicted by Carl Wernicke, who called it the senkrechte Occipitalbündel (vertical occipital bundle), [2] the region was practically lost to scientific knowledge during the twentieth century. [3] Theodor Meynert had described the brain's other white matter tracts as being horizontally oriented, and did not accept Wernicke's finding. Heinrich Obersteiner named the area the "fasciculus occipitalis perpendicularis", and Heinrich Sachs named the area the "stratum profundum convexitatis". It appeared in a 1918 edition of Gray's Anatomy, but fell into obscurity. [4] A diffusion tensor imaging (DTI) study in 2004 noted an area of short-range association fibers in the lateral occipital lobe, which they noted corresponded to the VoF. [5]

Structure and function

The vertical occipital fasciculus consists of long nerve fibers making connections between vision sub-regions in the rear of the brain. Research indicates that it is related to both vision and cognition, since injury to it can cause reading impairment. [6]

Related Research Articles

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Brainstem Posterior part of the brain, adjoining and structurally continuous

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Corpus callosum White matter tract connecting the two cerebral hemispheres

The corpus callosum, also callosal commissure, is a wide, thick nerve tract, consisting of a flat bundle of commissural fibers, beneath the cerebral cortex in the brain. The corpus callosum is only found in placental mammals. It spans part of the longitudinal fissure, connecting the left and right cerebral hemispheres, enabling communication between them. It is the largest white matter structure in the human brain, about ten centimetres in length and consisting of 200–300 million axonal projections.

Wernicke–Korsakoff syndrome Combined presence of Wernickes encephalopathy (WE) and Korsakoffs syndrome

Wernicke–Korsakoff syndrome (WKS) is the combined presence of Wernicke encephalopathy (WE) and Korsakoff syndrome. Due to the close relationship between these two disorders, people with either are usually diagnosed with WKS as a single syndrome. It mainly causes vision changes, ataxia and impaired memory.

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Wernicke's area, also called Wernicke's speech area, is one of the two parts of the cerebral cortex that are linked to speech, the other being Broca's area. It is involved in the comprehension of written and spoken language, in contrast to Broca's area, which is involved in the production of language. It is traditionally thought to reside in Brodmann area 22, which is located in the superior temporal gyrus in the dominant cerebral hemisphere, which is the left hemisphere in about 95% of right-handed individuals and 70% of left-handed individuals.

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Carl Wernicke German physician and neuropathologist (1848–1905)

CarlWernicke was a German physician, anatomist, psychiatrist and neuropathologist. He is known for his influential research into the pathological effects of specific forms of encephalopathy and also the study of receptive aphasia, both of which are commonly associated with Wernicke's name and referred to as Wernicke encephalopathy and Wernicke's aphasia, respectively. His research, along with that of Paul Broca, led to groundbreaking realizations of the localization of brain function, specifically in speech. As such, Wernicke's area has been named after the scientist.

Longitudinal fissure

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Arcuate fasciculus

The arcuate fasciculus (AF) is a bundle of axons that generally connects the Broca's area and the Wernicke's area in the brain. It is an association fiber tract connecting caudal temporal cortex and inferior frontal lobe. Fasciculus arcuatus is latin for curved bundle.

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Anterior commissure

The anterior commissure is a white matter tract connecting the two temporal lobes of the cerebral hemispheres across the midline, and placed in front of the columns of the fornix. In most existing mammals, the great majority of fibers connecting the two hemispheres travel through the corpus callosum, which is over 10 times larger than the anterior commissure, and other routes of communication pass through the hippocampal commissure or, indirectly, via subcortical connections. Nevertheless, the anterior commissure is a significant pathway that can be clearly distinguished in the brains of all mammals.

The mammillothalamic tract arises from cells in both the medial and lateral nuclei of the mammillary body and by fibers that are directly continued from the fornix.

Inferior longitudinal fasciculus

The inferior longitudinal fasciculus (ILF) is traditionally considered one of the major occipitotemporal association tracts. It is the white matter backbone of the ventral visual stream. It connects the ventral surface of the anterior temporal lobe and the extrastriate cortex of the occipital lobe, running along the lateral and inferior wall of the lateral ventricle.

Amperometry in chemistry is detection of ions in a solution based on electric current or changes in electric current.

Disconnection syndrome Collection of neurological symptoms

Disconnection syndrome is a general term for a collection of neurological symptoms caused -- via lesions to associational or commissural nerve fibres -- by damage to the white matter axons of communication pathways in the cerebrum, independent of any lesions to the cortex. The behavioral effects of such disconnections are relatively predictable in adults. Disconnection syndromes usually reflect circumstances where regions A and B still have their functional specializations except in domains that depend on the interconnections between the two regions.

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References

  1. Yeatman, J.D.; et al. (November 17, 2014). "The vertical occipital fasciculus: A century of controversy resolved by in vivo measurements". PNAS. 111 (48): E5214–E5223. Bibcode:2014PNAS..111E5214Y. doi: 10.1073/pnas.1418503111 . PMC   4260539 . PMID   25404310.
  2. Wernicke, Carl (1881) Lehrbuch der Gehirnkrankheiten: für Aerzte und Studirende, Fig. 19 on p. 30. https://archive.org/stream/lehrbuchdergehir00wern#page/n49/mode/1up. Accessed 2014.11.18.
  3. Yeatman, J. D., et al. (2014). The vertical occipital fasciculus: A century of controversy resolved by in vivo measurements.PNAS, DOI: 10.1073/pnas.1418503111, abstract. Accessed 2014.11.18
  4. "Major brain pathway rediscovered". TheGuardian.com . 17 November 2014.
  5. Wakana, Setsu; Jiang, Hangyi; Nagae-Poetscher, Lidia M.; van Zijl, Peter C. M.; Mori, Susumu (January 2004). "Fiber Tract–based Atlas of Human White Matter Anatomy1". Radiology. 230 (1): 77–87. doi:10.1148/radiol.2301021640. PMID   14645885.
  6. "Reading and the Brain: Rediscovery of a Major Pathway | Institute for Learning and Brain Sciences (I-LABS)".

Further reading