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Emil von Behring, born Emil Adolf Behring, was a German physiologist who received the 1901 Nobel Prize in Physiology or Medicine, the first one awarded in that field, for his discovery of a diphtheria antitoxin. He was widely known as a "saviour of children", as diphtheria used to be a major cause of child death. His work with the disease, as well as tetanus, has come to bring him most of his fame and acknowledgment. He was honoured with Prussian nobility in 1901, henceforth being known by the surname "von Behring."
Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks, the mortality rate approaches 10%. Signs and symptoms may vary from mild to severe, and usually start two to five days after exposure. Symptoms often develop gradually, beginning with a sore throat and fever. In severe cases, a grey or white patch develops in the throat, which can block the airway, and create a barking cough similar to what is observed in croup. The neck may also swell in part due to the enlargement of the facial lymph nodes. Diphtheria can also involve the skin, eyes, or genitals, and can cause complications, including myocarditis, inflammation of nerves, kidney problems, and bleeding problems due to low levels of platelets.
Croup, also known as laryngotracheobronchitis, is a type of respiratory infection that is usually caused by a virus. The infection leads to swelling inside the trachea, which interferes with normal breathing and produces the classic symptoms of "barking/brassy" cough, inspiratory stridor and a hoarse voice. Fever and runny nose may also be present. These symptoms may be mild, moderate, or severe. Often it starts or is worse at night and normally lasts one to two days.
The year 1858 in science and technology involved some significant events, listed below.
Victor Babeș was a Romanian physician, bacteriologist, academician and professor. One of the founders of modern microbiology, Victor Babeș is author of one of the first treatises of bacteriology in the world – Bacteria and their role in pathological anatomy and histology of infectious diseases, written in collaboration with French scientist Victor André Cornil in 1885. In 1888, Babeș underlies the principle of passive immunity, and a few years later enunciates the principle of antibiosis. He made early and significant contributions to the study of rabies, leprosy, diphtheria, tuberculosis and other infectious diseases. He also discovered more than 50 unknown germs and foresaw new methods of staining bacteria and fungi. Victor Babeș introduced rabies vaccination and founded serotherapy in Romania.
A toxoid is an inactivated toxin whose toxicity has been suppressed either by chemical (formalin) or heat treatment, while other properties, typically immunogenicity, are maintained. Toxins are secreted by bacteria, whereas toxoids are altered form of toxins; toxoids are not secreted by bacteria. Thus, when used during vaccination, an immune response is mounted and immunological memory is formed against the molecular markers of the toxoid without resulting in toxin-induced illness. Such a preparation is also known as an anatoxin. There are toxoids for prevention of diphtheria, tetanus and botulism.
The Mayor of San Jose, officially the Mayor of the City of San José, is executive of the Government of the City of San Jose, California in the United States.
Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treatment of diphtheria. It is no longer recommended for prevention of diphtheria. It is administered through injection into a vein or muscle.
In immunology, passive immunity is the transfer of active humoral immunity of ready-made antibodies. Passive immunity can occur naturally, when maternal antibodies are transferred to the fetus through the placenta, and it can also be induced artificially, when high levels of antibodies specific to a pathogen or toxin are transferred to non-immune persons through blood products that contain antibodies, such as in immunoglobulin therapy or antiserum therapy. Passive immunization is used when there is a high risk of infection and insufficient time for the body to develop its own immune response, or to reduce the symptoms of ongoing or immunosuppressive diseases. Passive immunization can be provided when people cannot synthesize antibodies, and when they have been exposed to a disease that they do not have immunity against.
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Kenya has a severe, generalized HIV epidemic, but in recent years, the country has experienced a notable decline in HIV prevalence, attributed in part to significant behavioral change and increased access to ARV. Adult HIV prevalence is estimated to have fallen from 10 percent in the late 1990s to about 4.8 percent in 2017. Women face considerably higher risk of HIV infection than men but have longer life expectancies than men when on ART. The 7th edition of AIDS in Kenya reports an HIV prevalence rate of eight percent in adult women and four percent in adult men. Populations in Kenya that are especially at risk include injecting drug users and people in prostitution, whose prevalence rates are estimated at 53 percent and 27 percent, respectively. Men who have sex with men (MSM) are also at risk at a prevalence of 18.2%. Other groups also include discordant couples however successful ARV-treatment will prevent transmission. Other groups at risk are prison communities, uniformed forces, and truck drivers.
Diphtheria vaccine is a toxoid vaccine against diphtheria, an illness caused by Corynebacterium diphtheriae. Its use has resulted in a more than 90% decrease in number of cases globally between 1980 and 2000. The first dose is recommended at six weeks of age with two additional doses four weeks apart, after which it is about 95% effective during childhood. Three further doses are recommended during childhood. It is unclear if further doses later in life are needed.
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Peter V, nicknamed "the Hopeful", was King of Portugal from 1853 to 1861.
Gideon Allen Weed born in New Jersey, Weed was a two-time mayor of Seattle, Washington from 1876 to 1878, first elected in 1875, and serving as an independent.
John Strother Griffin (1816–1898) was a surgeon attached to the General Stephen W. Kearney expedition from New Mexico to California, a landowner and founder of East Los Angeles and a member of the Common Council of the city of Los Angeles, where he was one of the first university-trained physicians to settle.
The opioid epidemic, also referred to as the opioid crisis, is the rapid increase in the overuse, misuse/abuse, and overdose deaths attributed either in part or in whole to the class of drugs called opiates/opioids since the 1990s. It includes the significant medical, social, psychological, demographic and economic consequences of the medical, non-medical, and recreational abuse of these medications.
An epidemic of smallpox in 1856 on the west Pacific island of Guam, then under the control of Spain, resulted in the death of over half of the population, or about 4,500 people. The population collapse led Spanish authorities to transfer the population of Pago to Hagåtña, ending a settlement dating back before colonization. It also led the Governor of the Spanish Mariana Islands to encourage immigration to Guam.
References
- ↑ Fourgeaud, Victor J. (1858). Diphtheritis: a concise historical and critical essay on the late epidemic pseudo-membranous sore throat of California (1856-7), with a few remarks illustrating the diagnosis, pathology, and treatment of the disease. California: Sacramento : J. Anthony & Co., 1858. Archived from the original on 2013-05-21. Retrieved 2012-11-29.
- ↑ "Diphtheria Timeline". History of Vaccines. Retrieved 29 November 2012. Click through to "Toward Diphtheria Immunization" timeline, and choose "1856: Diphtheria in California."
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