Vitamin C is a vitamin found in various foods and sold as a dietary supplement. It is used to prevent and treat scurvy. Vitamin C is an essential nutrient involved in the repair of tissue and the enzymatic production of certain neurotransmitters. It is required for the functioning of several enzymes and is important for immune system function. It also functions as an antioxidant. Most animals are able to synthesize their own vitamin C, although humans, the other great and lesser apes, monkeys, most bats, some rodents, and certain other animals must acquire it from dietary sources.
A vitamin is an organic molecule (or a set of molecules closely related chemically, i.e. vitamers) that is an essential micronutrient which an organism needs in small quantities for the proper functioning of its metabolism. Essential nutrients cannot be synthesized in the organism, either at all or not in sufficient quantities, and therefore must be obtained through the diet. Vitamin C can be synthesized by some species but not by others; it is not a vitamin in the first instance but is in the second. The term vitamin does not include the three other groups of essential nutrients: minerals, essential fatty acids, and essential amino acids. Most vitamins are not single molecules, but groups of related molecules called vitamers. For example, there are eight vitamers of vitamin E: four tocopherols and four tocotrienols. Some sources list fourteen vitamins, by including choline, but major health organizations list thirteen: vitamin A (as all-trans-retinol, all-trans-retinyl-esters, as well as all-trans-beta-carotene and other provitamin A carotenoids), vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid or folate), vitamin B12 (cobalamins), vitamin C (ascorbic acid), vitamin D (calciferols), vitamin E (tocopherols and tocotrienols), and vitamin K (phylloquinone and menaquinones).
Linus Carl Pauling was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of four people to have won more than one Nobel Prize. Of these, he is the only person to have been awarded two unshared Nobel Prizes, and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie.
Orthomolecular medicine is a form of alternative medicine that aims to maintain human health through nutritional supplementation. The concept builds on the idea of an optimal nutritional environment in the body and suggests that diseases reflect deficiencies in this environment. Treatment for disease, according to this view, involves attempts to correct "imbalances or deficiencies based on individual biochemistry" by use of substances such as vitamins, minerals, amino acids, trace elements and fatty acids. The notions behind orthomolecular medicine are not supported by sound medical evidence, and the therapy is not effective; even the validity of calling the orthomolecular approach a form of medicine has been questioned since the 1970s.
Émile Zuckerkandl was an Austrian-born French biologist considered one of the founders of the field of molecular evolution. He is best known for introducing, with Linus Pauling, the concept of the "molecular clock", which enabled the neutral theory of molecular evolution.
Arthur Brouhard Robinson is an American biochemist, conservative activist, and politician, serving as Oregon State Senator from the 2nd District since 2021. He was the five-time Republican nominee for the United States House of Representatives for Oregon's 4th congressional district.
Herman Russell Branson was an American physicist, chemist, best known for his research on the alpha helix protein structure, and was also the president of two colleges.
Megavitamin therapy is the use of large doses of vitamins, often many times greater than the recommended dietary allowance (RDA) in the attempt to prevent or treat diseases. Megavitamin therapy is typically used in alternative medicine by practitioners who call their approach orthomolecular medicine. Vitamins are useful in preventing and treating illnesses specifically associated with dietary vitamin shortfalls, but the conclusions of medical research are that the broad claims of disease treatment by advocates of megavitamin therapy are unsubstantiated by the available evidence. It is generally accepted that doses of any vitamin greatly in excess of nutritional requirements will result either in toxicity or in the excess simply being metabolised; thus evidence in favour of vitamin supplementation supports only doses in the normal range. Critics have described some aspects of orthomolecular medicine as food faddism or even quackery. Research on nutrient supplementation in general suggests that some nutritional supplements might be beneficial, and that others might be harmful; several specific nutritional therapies are associated with an increased likelihood of the condition they are meant to prevent.
Irwin Stone (1907–1984) was an American biochemist, chemical engineer, and author. He was the first to use ascorbic acid in the food processing industry as a preservative, and originated and published the hypothesis that humans require much larger amounts of Vitamin C for optimal health than is necessary to prevent scurvy.
Molecular medicine is a broad field, where physical, chemical, biological, bioinformatics and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them. The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs.
William Bosworth Castle was an American physician and physiologist who transformed hematology from a "descriptive art to a dynamic interdisciplinary science."
Vitamin C megadosage is a term describing the consumption or injection of vitamin C in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day. There is no scientific evidence that vitamin C megadosage helps to cure or prevent cancer, the common cold, or some other medical conditions.
The common cold, or simply the cold, is a viral infectious disease of the upper respiratory tract. The cold is indeed common, and is a significant cause for absences from work and school. Even before the discovery of vitamin C, folklore had it that certain fruits were effective in both preventing and treating the cold. After scientific identification of vitamin C in the early part of the 20th century, research began into the possible effects of the vitamin against the common cold. Vitamin C does not decrease the frequency of colds in the general population, but it has halved the frequency of colds in people under heavy short-term physical stress. There is no effect of taking vitamin C in doses up to 8 grams per day after a cold has already begun.
Harvey Akio Itano was an American biochemist best known for his work on the molecular basis of sickle cell anemia and other diseases. In collaboration with Linus Pauling, Itano used electrophoresis to demonstrate the difference between normal hemoglobin and sickle cell hemoglobin; their 1949 paper "Sickle Cell Anemia, a Molecular Disease" was a landmark in both molecular medicine and protein electrophoresis.
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood. The paper, published in the November 25, 1949 issue of Science, reports a difference in electrophoretic mobility between hemoglobin from healthy individuals and those with sickle-cell anemia, with those with sickle cell trait having a mixture of the two types. The paper suggests that the difference in electrophoretic mobility is probably due to a different number of ionizable amino acid residues in the protein portion of hemoglobin, and that this change in molecular structure is responsible for the sickling process. It also reports the genetic basis for the disease, consistent with the simultaneous genealogical study by James V. Neel: those with sickle-cell anemia are homozygous for the disease gene, while heterozygous individuals exhibit the usually asymptomatic condition of sickle cell trait.
Alternative treatments used for the common cold include numerous home remedies and alternative medicines. Scientific research regarding the efficacy of each treatment is generally nonexistent or inconclusive. Current best evidence indicates prevention, including hand washing and neatness, and management of symptoms.
Randy Jirtle is an American biologist noted for his research in epigenetics, the branch of biology that deals with inherited information that does not reside in the nucleotide sequence of DNA. Jirtle retired from Duke University, Durham, NC in 2012. He is Professor of Epigenetics in the Department of Biological Sciences at North Carolina State University, Raleigh, NC, and Senior Visiting Scientist at the McArdle Laboratory of Cancer Research, University of Wisconsin, Madison, WI. Jirtle is noted for his research on genomic imprinting, and for his use of the Agouti mouse model to investigate the effect of environmental agents on the mammalian epigenome and disease susceptibility.
Intravenous Ascorbic Acid, is a process that delivers soluble ascorbic acid directly into the bloodstream. It is not approved for use to treat any medical condition.
Franklin Church Bing was an American biochemist, advisor and archivist. He was born in the United States. He got his PhD in the physiological chemistry department of Yale University in 1930. After that he joined the Western Reserve University between 1929 and 1936 and became a faculty member in the department of Biochemistry. After many years of studying, in later career, he joined the American Medical Association (AMA) and became a scientific researcher from 1936. Then between 1943 and 1950, Bing worked for the American Institute of Baking in Chicago. From 1950 to 1952, he worked as an advisor to the Delaney Committee of the United States House of Representatives. Since then, he has become an independent food and drug advisor for private businesses and government agencies. In 1985, Franklin Church Bing became an archivist and worked for the American Institute of Nutrition. At the same time, he wrote several biographies for many nutritionists. Franklin Church Bing was a nutritionist, scientist and a chemist and he had studied and made many contributions to these related fields during his whole life.
Nobel disease or Nobelitis is the embracing of strange or scientifically unsound ideas by some Nobel Prize winners, usually later in life. It has been argued that the effect results, in part, from a tendency for Nobel winners to feel empowered by the award to speak on topics outside their specific area of expertise, although it is unknown whether Nobel Prize winners are more prone to this tendency than other individuals. Paul Nurse, co-winner of the 2001 Nobel Prize in Physiology or Medicine, warned later laureates against "believing you are expert in almost everything, and being prepared to express opinions about most issues with great confidence, sheltering behind the authority that the Nobel Prize can give you". Nobel disease has been described as a "tongue in cheek" term.
