Volenrelaxin

Volenrelaxin
Clinical data
Other names	LY3540378
Legal status
Legal status	Investigational;
Identifiers
CAS Number	2653949-19-8 ;
UNII	TVT9XLV5MU ;
KEGG	D12783 ;

Last updated June 30, 2025

Volenrelaxin (LY3540378) is a long-acting, synthetic analogue of relaxin developed by Eli Lilly and Company to treat heart failure.^[1]^[2]

References

↑ Almeida-Pinto, Nísia; Dschietzig, Thomas Bernd; Brás-Silva, Carmen; Adão, Rui (18 September 2023). "Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives". Clinical Research in Cardiology. 113 (8): 1137–1150. doi: 10.1007/s00392-023-02305-1 . hdl: 10216/150307 . PMC 11269324 . PMID 37721595.
↑ Verdino, Petra; Lee, Stacey L.; Cooper, Fariba N.; Cottle, Steven R.; Grealish, Patrick F.; Hu, Charlie C.; Meyer, Catalina M.; Lin, Joanne; Copeland, Victoria; Porter, Gina; Schroeder, Richard L.; Thompson, Tyran D.; Porras, Leah L.; Dey, Asim; Zhang, Hong Y.; Beebe, Emily C.; Matkovich, Scot J.; Coskun, Tamer; Balciunas, Aldona M.; Ferrante, Andrea; Siegel, Robert; Malherbe, Laurent; Bivi, Nicoletta; Paavola, Chad D.; Hansen, Ryan J.; Abernathy, Matthew M.; Nwosu, Sylvia O.; Carr, Molly C.; Heuer, Josef G.; Wang, Xiaojun (August 2023). "Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure". British Journal of Pharmacology. 180 (15): 1965–1980. doi: 10.1111/bph.16055 . PMID 36780899.

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[1] Almeida-Pinto, Nísia; Dschietzig, Thomas Bernd; Brás-Silva, Carmen; Adão, Rui (18 September 2023). "Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives". Clinical Research in Cardiology. 113 (8): 1137–1150. doi: 10.1007/s00392-023-02305-1 . hdl: 10216/150307 . PMC 11269324 . PMID 37721595.

[2] Verdino, Petra; Lee, Stacey L.; Cooper, Fariba N.; Cottle, Steven R.; Grealish, Patrick F.; Hu, Charlie C.; Meyer, Catalina M.; Lin, Joanne; Copeland, Victoria; Porter, Gina; Schroeder, Richard L.; Thompson, Tyran D.; Porras, Leah L.; Dey, Asim; Zhang, Hong Y.; Beebe, Emily C.; Matkovich, Scot J.; Coskun, Tamer; Balciunas, Aldona M.; Ferrante, Andrea; Siegel, Robert; Malherbe, Laurent; Bivi, Nicoletta; Paavola, Chad D.; Hansen, Ryan J.; Abernathy, Matthew M.; Nwosu, Sylvia O.; Carr, Molly C.; Heuer, Josef G.; Wang, Xiaojun (August 2023). "Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure". British Journal of Pharmacology. 180 (15): 1965–1980. doi: 10.1111/bph.16055 . PMID 36780899.

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