Author | Paul Kalanithi |
---|---|
Country | United States |
Language | English |
Subject | Autobiography |
Publisher | Random House (US) Bodley Head (UK) |
Publication date | January 12, 2016 |
Media type | |
Pages | 228 |
ISBN | 9781847923677 Hardback |
OCLC | 909925278 |
616.99/424 | |
LC Class | RC280 |
When Breath Becomes Air is a non-fiction autobiographical book written by American neurosurgeon Paul Kalanithi. It is a memoir about his life and battling stage IV metastatic lung cancer. It was posthumously published by Random House on January 12, 2016. [1]
In his last year of neurosurgical residency at Stanford University, Kalanithi experiences negative changes in his health. Rapid weight loss and severe back and chest pains begin to raise concern for him and his wife, Lucy Kalanithi. He worries that cancer might have caused his symptoms and his decline of health – unlikely for people in their thirties. However, when the X-ray results in a routine medical check-up return normal, he and his primary care physician attribute the symptoms to aging and work overload. [2]
Determined to finish the last months of his residency, he ignores whatever symptoms have not subsided. A few weeks later, the symptoms come back, stronger than before. Around this time, Kalanithi and his wife experience conflict in their relationship when Lucy feels that he is not communicating with her. Visiting friends in New York, Kalanithi is almost certain that he has cancer and says it out loud for the first time to his friend Mike. Returning home, upon landing in San Francisco, Kalanithi receives a call from his doctor telling him that his lungs "look blurry." When he arrives home with Lucy, both of them know what is happening. The next day, Kalanithi checks in to the hospital, and the room where he examined his patients, delivering good and bad news, becomes his own. [2]
Before writing When Breath Becomes Air, Kalanithi was in residency in neurological surgery and a postdoctoral fellowship in neuroscience. In May 2013, he was diagnosed with stage-4 non-small-cell EGFR-positive lung cancer. [3]
As Kalanithi underwent cancer treatment, he shared his reflections on illness and medicine, authoring essays in The New York Times, [4] The Paris Review, [5] and Stanford Medicine, [6] and participating in interviews for media outlets and public forums. [7] He also began work on an autobiographical book of his experiences as a doctor and a patient facing a terminal illness. [3]
Kalanithi died in March 2015 at the age of 37. His memoir was published posthumously 10 months later. [8] The book includes a foreword by Abraham Verghese and an epilogue by Kalanithi's widow, Lucy Goddard Kalanithi.
The author of the book, Paul Kalanithi, was born in Bronxville, New York, on April 1, 1977. [3] At the age of 10, his family moved to Kingman, Arizona, where he spent most of his youth. At the early age of 10, his mother gave him books to read in order to educate his young mind. Kalanithi attended Stanford University where he earned a Bachelor and Master of Arts in English literature and a Bachelor of Science in human biology. [2] He attended Cambridge for history and philosophy of science and medicine where he obtained his Masters. After Cambridge, Kalanithi attended Yale for medical school where he met his future wife, Lucy Goddard. After graduating from Yale, they got married and began their residencies in California. Kalanithi started his residency back at Stanford while his wife attended the University of California, San Francisco. [2] Paul and Lucy have a daughter together. [2]
Following the prospect of a better life, Kalanithi's father moves the family from Bronxville, New York, to Kingman, Arizona, when Kalanithi is ten. A doctor himself, Kalanithi's father dedicates most of his time to medicine and is notably absent from the house. Believing that to be a doctor, he would have to be away from the family like his father, Kalanithi becomes disenchanted with medicine. Although he and his two brothers enjoy the newfound liberty of their desert town, their mother constantly worries about their academic future in a town that the U.S. census has declared “the least educated district in America.” [2] Unwilling to let anything halt their learning, she acquires college reading lists and instills in her sons a love for literature. The summer before heading to Stanford University for school, Kalanithi reads Satan, His Psychotherapy and Cure by the Unfortunate Dr. Kassler, J.S.P.S. , by Jeremy Leven. The book's idea that the mind is the result of the brain doing its work awakes a curiosity in Kalanithi for neuroscience.
After completing degrees in English literature and human biology, Kalanithi feels there is still much to learn. He is accepted to a master's program in English literature at Stanford, and one afternoon—pushed by his desire to understand the meaning of life— discovers the calling to practice medicine for the first time. Preparing to apply to medical school, Kalanithi uses the time off to study the history and philosophy of science and medicine at Cambridge. He later starts medical school at Yale. During his time at Yale, Kalanithi meets his wife, Lucy, and sees the patient-doctor relationship as an example of life, death, and morality coming together. After two years of classroom learning, Kalanithi experiences his first birth and death in his OB-GYN clinical rotation, when a set of twins could not be carried to term. It is then that Kalanithi understands that intelligence is not enough in the practice of medicine and that morality is also needed. After medical school, Lucy Kalanithi starts an internal medicine residency at UCSF, and Paul Kalanithi begins a neurosurgical residency at Stanford. Though he finds it hard at first, Kalanithi grows used to the rigor of neurosurgery and, in his fourth year, joins the neuroscience lab of a professor affectionately called “V.” In the sixth year of residency, Kalanithi returns to his hospital duties and having reached professional recognition, he feels he has finally found his place in the world. [2]
Kalanithi's life takes an unexpected turn when, after weeks of health problems, it is confirmed that he has lung cancer. Images obtained from a CT scan show organ systems compromised by cancer, causing him and his wife great sadness. Searching for the best experts in the field of oncology, Kalanithi begins treatment with a doctor named Emma Hayward. Because of his status, rather than stepping back and letting Hayward offer her professional opinion, Kalanithi expects to be treated as a consultant, even if it is his own case. Hayward suggests finding the root of his cancer before determining treatment options. In the meantime, Kalanithi's family helps him through his transition from doctor to patient, and together with Lucy, he decides to explore reproductive options before he dies. They visit a sperm bank and make a decision to have a child. Test results arrive, and Kalanithi discovers that his cancer is derived from a mutation in the epidermal growth factor receptor (EGFR). This fact gives him a bit of relief because it means that he can be treated with Tarceva, which typically results in less-severe side effects compared to traditional chemotherapy. [2]
Symptoms subside with the treatment, and in Dr. Hayward's office, Kalanithi feels like himself again. After weeks of using the medication, CT scans show a reduced number of tumors in Kalanithi's lungs, and he becomes determined to return to the operating room. Back in the OR, he cannot finish his first surgery because of his health. However, his strength and technique improve over time. With both graduation and a baby due in June, he takes another CT scan after months since the last. He discovers a big tumor in his right lung, and without getting scared, he and Lucy research what other options are available. Kalanithi retires from surgery indefinitely and begins chemotherapy. His response to chemotherapy is adverse, and his health worsens, forcing him to skip graduation. With the failure of chemotherapy, other treatment options do not provide him much hope. His condition becomes so severe that even Dr. Hayward gives an approximation of how much time he has left – something she had strongly refused to do before. On July 4, 2014, their daughter was born and Kalanithi is filled with joy. [2] Eventually, Kalanithi dies in the intensive care unit of his hospital.
The epilogue is written by his wife, Lucy Kalanithi, after his death. It shows her point of view on the experience with her husband Paul Kalanithi's lung cancer. It is an in-depth personal explanation of her experience.
When Breath Becomes Air is a New York Times bestseller, spending 68 weeks on the non-fiction bestseller list. [9] The book was well-received by critics, [10] including starred reviews from Kirkus Reviews [11] and Library Journal . [12]
Kirkus called the book a "moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity." [11]
Matt McCarthy of USA Today gave it 4 out of 4 stars and said, "It's a story so remarkable, so stunning, and so affecting that I had to take dozens of breaks just to compose myself enough to get through it." [13] Nick Romeo of The Boston Globe wrote that it "possesses the gravity and wisdom of an ancient Greek tragedy." [14] Melissa Maerz of Entertainment Weekly stated that the book was "so original—and so devastating. . . . Its only fault is that the book, like his life, ends much too early." [15]
Year | Award | Result | Ref. |
---|---|---|---|
2016 | Goodreads Choice Award for Memoir & Autobiography | Winner | [16] |
Waterstones Book of the Year | Shortlist | [17] | |
2017 | Jan Michalski Prize | Second selection | [18] |
Prix Jan Michalski | Second selection | ||
Pulitzer Prize, Biography or Autobiography | Finalist | [19] | |
Wellcome Book Prize | Shortlist | [20] [21] |
Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung. Lung cancer is caused by genetic damage to the DNA of cells in the airways, often caused by cigarette smoking or inhaling damaging chemicals. Damaged airway cells gain the ability to multiply unchecked, causing the growth of a tumor. Without treatment, tumors spread throughout the lung, damaging lung function. Eventually lung tumors metastasize, spreading to other parts of the body.
Shortness of breath (SOB), also medically known as dyspnea or dyspnoea, is an uncomfortable feeling of not being able to breathe well enough. The American Thoracic Society defines it as "a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity", and recommends evaluating dyspnea by assessing the intensity of its distinct sensations, the degree of distress and discomfort involved, and its burden or impact on the patient's activities of daily living. Distinct sensations include effort/work to breathe, chest tightness or pain, and "air hunger". The tripod position is often assumed to be a sign.
A radiation oncologist is a specialist physician who uses ionizing radiation in the treatment of cancer. Radiation oncology is one of the three primary specialties, the other two being surgical and medical oncology, involved in the treatment of cancer. Radiation can be given as a curative modality, either alone or in combination with surgery and/or chemotherapy. It may also be used palliatively, to relieve symptoms in patients with incurable cancers. A radiation oncologist may also use radiation to treat some benign diseases, including benign tumors. In some countries, radiotherapy and chemotherapy are controlled by a single oncologist who is a "clinical oncologist". Radiation oncologists work closely with other physicians such as surgical oncologists, interventional radiologists, internal medicine subspecialists, and medical oncologists, as well as medical physicists and technicians as part of the multi-disciplinary cancer team. Radiation oncologists undergo four years of oncology-specific training whereas oncologists who deliver chemotherapy have two years of additional training in cancer care during fellowship after internal medicine residency in the United States.
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs. The area most commonly affected is the lining of the lungs and chest wall. Less commonly the lining of the abdomen and rarely the sac surrounding the heart, or the sac surrounding the testis may be affected. Signs and symptoms of mesothelioma may include shortness of breath due to fluid around the lung, a swollen abdomen, chest wall pain, cough, feeling tired, and weight loss. These symptoms typically come on slowly.
Pleurisy, also known as pleuritis, is inflammation of the membranes that surround the lungs and line the chest cavity (pleurae). This can result in a sharp chest pain while breathing. Occasionally the pain may be a constant dull ache. Other symptoms may include shortness of breath, cough, fever, or weight loss, depending on the underlying cause. Pleurisy can be caused by a variety of conditions, including viral or bacterial infections, autoimmune disorders, and pulmonary embolism.
Asbestosis is long-term inflammation and scarring of the lungs due to asbestos fibers. Symptoms may include shortness of breath, cough, wheezing, and chest tightness. Complications may include lung cancer, mesothelioma, and pulmonary heart disease.
Malignancy is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of cancer.
Cardiothoracic surgery is the field of medicine involved in surgical treatment of organs inside the thoracic cavity — generally treatment of conditions of the heart, lungs, and other pleural or mediastinal structures.
Terminal illness or end-stage disease is a disease that cannot be cured or adequately treated and is expected to result in the death of the patient. This term is more commonly used for progressive diseases such as cancer, dementia or advanced heart disease than for injury. In popular use, it indicates a disease that will progress until death with near absolute certainty, regardless of treatment. A patient who has such an illness may be referred to as a terminal patient, terminally ill or simply as being terminal. There is no standardized life expectancy for a patient to be considered terminal, although it is generally months or less. Life expectancy for terminal patients is a rough estimate given by the physician based on previous data and does not always reflect true longevity. An illness which is lifelong but not fatal is a chronic condition.
Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract. Compared to non-small cell carcinoma, small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases.
Pneumonitis describes general inflammation of lung tissue. Possible causative agents include radiation therapy of the chest, exposure to medications used during chemo-therapy, the inhalation of debris, aspiration, herbicides or fluorocarbons and some systemic diseases. If unresolved, continued inflammation can result in irreparable damage such as pulmonary fibrosis.
Respiratory diseases, or lung diseases, are pathological conditions affecting the organs and tissues that make gas exchange difficult in air-breathing animals. They include conditions of the respiratory tract including the trachea, bronchi, bronchioles, alveoli, pleurae, pleural cavity, the nerves and muscles of respiration. Respiratory diseases range from mild and self-limiting, such as the common cold, influenza, and pharyngitis to life-threatening diseases such as bacterial pneumonia, pulmonary embolism, tuberculosis, acute asthma, lung cancer, and severe acute respiratory syndromes, such as COVID-19. Respiratory diseases can be classified in many different ways, including by the organ or tissue involved, by the type and pattern of associated signs and symptoms, or by the cause of the disease.
Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small-cell carcinoma. When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy has been used increasingly both preoperatively and postoperatively.
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment. Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies, and PARP inhibitors such as olaparib. Other therapies include hyperthermia, immunotherapy, photodynamic therapy, and stem-cell therapy. Most commonly cancer treatment involves a series of separate therapies such as chemotherapy before surgery. Angiogenesis inhibitors are sometimes used to enhance the effects of immunotherapies.
Adenocarcinoma of the lung is the most common type of lung cancer, and like other forms of lung cancer, it is characterized by distinct cellular and molecular features. It is classified as one of several non-small cell lung cancers (NSCLC), to distinguish it from small cell lung cancer which has a different behavior and prognosis. Lung adenocarcinoma is further classified into several subtypes and variants. The signs and symptoms of this specific type of lung cancer are similar to other forms of lung cancer, and patients most commonly complain of persistent cough and shortness of breath.
David John Sugarbaker was an American physician who was chief of the division of general thoracic surgery and the director of the Baylor College of Medicine Lung Institute at CHI St. Luke's Health–Baylor St. Luke's Medical Center in Houston, Texas. He was an internationally recognized thoracic surgeon specializing in the treatment of mesothelioma, the surgical management of malignant pleural mesothelioma, and treatment of complex thoracic cancers.
Paul Sudhir Arul Kalanithi was an American neurosurgeon and writer. His book When Breath Becomes Air is a memoir about his life and illness with stage IV metastatic lung cancer. It was posthumously published by Random House in January 2016. It was on The New York Times Non-Fiction Best Seller list for multiple weeks.
Cemiplimab, sold under the brand name Libtayo, is a monoclonal antibody medication for the treatment of squamous cell skin cancer. Cemiplimab belongs to a class of drugs that binds to the programmed death receptor-1 (PD-1), blocking the PD-1/PD-L1 pathway.
End Game is a 2018 American short documentary film by Rob Epstein and Jeffrey Friedman about terminally ill patients in a San Francisco hospital meeting medical practitioners seeking to change the perception around life and death. The film was executive produced by Steven Ungerleider and Shoshana R. Ungerleider. It was released by Netflix.
Limited-stage small cell lung carcinoma (LS-SCLC) is a type of small cell lung cancer (SCLC) that is confined to an area which is small enough to be encompassed within a radiation portal. This generally includes cancer to one side of the lung and those might have reached the lymph nodes on the same side of the lung. 33% patients with small cell lung cancer are diagnosed with limited-stage small cell lung carcinoma when it is first found. Common symptoms include but are not limited to persistent cough, chest pain, rust-coloured sputum, shortness of breath, fatigue, weight loss, wheezing, hoarseness and recurrent respiratory tract infections such as pneumonia and bronchitis. Nervous system problems, Cushing syndrome and SIADH can also be associated with small cell lung cancer. Unlike extensive-stage small cell lung cancer, limited-stage small cell lung carcinoma is potentially curable. Standard treatments consist of surgery, platinum-based combination chemotherapy, thoracic irradiation, and prophylactic cranial irradiation. Patient five-year survival rate has significantly increased from 1% with surgery to 26% after the application of combination chemotherapy.
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