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|Directed by||George B. Seitz|
|Written by|| Sidney Howard (play)|
Paul de Kruif (play collaborator)
Edward Chodorov (screenplay)
|Based on||Yellow Jack by Sidney Howard and Paul de Kruif|
|Produced by||Jack Cummings|
|Starring|| Robert Montgomery |
|Edited by||Blanche Sewell|
|Music by||William Axt|
Yellow Jack is a 1938 film released by Metro-Goldwyn-Mayer based on the 1934 play Yellow Jack .  Both were co-written by Sidney Howard and Paul de Kruif (the former a Pulitzer- and Oscar-winning playwright and screenwriter; the latter a well-known microbiologist and author). 
Produced and directed by the legendary Guthrie McClintic, the original Broadway play co-starred James Stewart and Sam Levene and opened at the Martin Beck Theatre, March 6, 1934.  Stewart's performance as Sergeant John O'Hara in the Broadway production of Yellow Jack attracted the attention of Hollywood along with a MGM contract. Unfortunately when Yellow Jack was filmed, Stewart was unavailable and replaced by Robert Montgomery. Sam Levene was the only member of the original Broadway cast to also appear in the movie. The supporting cast also features Lewis Stone, Andy Devine, Henry Hull, Charles Coburn and Buddy Ebsen.
The plot line follows the events of the well-known "Walter Reed Boards", in which Major Walter Reed of the U.S. Army worked to diagnose and treat yellow fever (called “yellow jack”) in Cuba in 1898–1900. The U.S. Army Medical Corps doctors studied the theory by the Cuban doctor Carlos Finlay that the disease was caused by bites of infected Aedes aegypti mosquitoes, a concept which had been ridiculed. The dramas portrayed the soldiers who volunteered to be human "guinea pigs" by allowing themselves to be bitten and contract the deadly disease, for which no cure was then known. (See History of yellow fever.) 
The movie ends with the following tribute to the real volunteers of the Yellow Jack experiment:
Yellow Jack celebrates what these men did, rather than what they were. That their heroism, however, should not go unrecorded, their true names are here given:
The play and screenplay were adapted for television by Celanese Theatre (1952) and Producers' Showcase (1955), in episodes titled Yellow Jack.  
Yellow Jack was presented on Philip Morris Playhouse September 5, 1941. 
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