High-affinity zinc uptake system protein ZnuA | |||||||
---|---|---|---|---|---|---|---|
![]() The structure of ZnuA bound to zinc (gray sphere), with coordinating amino acids shown in white. From PDB: 2OSV . [1] | |||||||
Identifiers | |||||||
Organism | |||||||
Symbol | ZnuA | ||||||
PDB | 2OSV | ||||||
UniProt | P39172 | ||||||
|
High-affinity zinc uptake system membrane protein ZnuB | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Organism | |||||||
Symbol | ZnuB | ||||||
UniProt | P39832 | ||||||
|
High-affinity zinc uptake system membrane protein ZnuC | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Organism | |||||||
Symbol | ZnuC | ||||||
UniProt | P0A9X1 | ||||||
|
ZnuABC is a high-affinity transporter specialized for transporting zinc ions as part of a system for metal ion homeostasis in bacteria. The complex is a member of the ATP-binding cassette (ABC) transporter protein family. The transporter contains three protein components: [2] [3]
The expression of ZnuABC is regulated by the zinc uptake regulator (Zur) protein and is induced by conditions of zinc starvation. Because zinc is often a limiting factor in bacterial infections, some pathogenic bacteria are heavily dependent on ZnuABC to scavenge zinc from the environment in an animal host. [4]
The periplasmic protein ZnuA interacts with ZinT, another component of the regulon controlled by Zur, which is also involved in periplasmic zinc homeostasis. [4] [5] [6] [7]