(Histone-H3)-lysine-36 demethylase

(Histone-H3)-lysine-36 demethylase
Identifiers
EC no.	1.14.11.27
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

(Histone-H3)-lysine-36 demethylase (EC 1.14.11.27, JHDM1A, JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone demethylase, protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase) is an enzyme with systematic name protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase. ^[1] This enzyme catalyses the following chemical reaction

protein N6,N6-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O₂${\displaystyle \rightleftharpoons }$ protein L-lysine + 2 succinate + 2 formaldehyde + 2 CO₂ (overall reaction)

(1a) protein N6,N6-dimethyl-L-lysine + 2-oxoglutarate + O₂${\displaystyle \rightleftharpoons }$ protein N6-methyl-L-lysine + succinate + formaldehyde + CO₂

(1b) protein N6-methyl-L-lysine + 2-oxoglutarate + O2 ${\displaystyle \rightleftharpoons }$ protein L-lysine + succinate + formaldehyde + CO₂

(Histone-H3)-lysine-36 demethylase contains iron(II).

References

1. Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (February 2006). "Histone demethylation by a family of JmjC domain-containing proteins". Nature. 439 (7078): 811–6. Bibcode:2006Natur.439..811T. doi:10.1038/nature04433. PMID   16362057.

External links

• (histone-H3)-lysine-36+demethylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)