ABCC13

ABCC13
Identifiers
Aliases	ABCC13 , C21orf73, PRED6, ABCC13P, ATP binding cassette subfamily C member 13 (pseudogene)
External IDs	OMIM: 608835 GeneCards: ABCC13
Gene location (Human)
Chr.	Chromosome 21 (human)
End	14,362,754 bp
Orthologs
	150000
	n/a
	ENSG00000243064
	n/a
	n ; a
	n/a
	NM_138726 ; NM_172024 ; NM_172025 ; NM_172026
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Last updated March 08, 2022

Putative ATP-binding cassette transporter sub-family C member 13 is a protein that is not present in humans. In humans, ABCC13 is a pseudogene.^[3]

Function

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.^[3]

Related Research Articles

Multidrug resistance-associated protein 6 (MRP6) also known as ATP-binding cassette sub-family C member 6 (ABCC6) and multi-specific organic anion transporter E (MOAT-E) is a protein that in humans is encoded by the ABCC6 gene. The protein encoded by the ABCC6 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.

ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338.

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene.

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.

ATP-binding cassette sub-family G member 5 is a protein that in humans is encoded by the ABCG5 gene.

Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.

ATP-binding cassette transporter sub-family C member 11, also MRP8 is a membrane transporter that exports certain molecules from inside a cell. It is a protein that in humans is encoded by gene ABCC11.

ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene.

ATP-binding cassette sub-family B member 7, mitochondrial is a protein that in humans is encoded by the ABCB7 gene.

ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene.

ATP-binding cassette super-family B member 6, mitochondrial is a protein that in humans is encoded by the ABCB6 gene.

ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene.

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.

ATP-binding cassette sub-family D member 4 is a protein that in humans is encoded by the ABCD4 gene.

ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.

Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.

ATP-binding cassette sub-family A member 9 is a protein that in humans is encoded by the ABCA9 gene.

ATP-binding cassette, sub-family C member 9 (ABCC9) also known as sulfonylurea receptor 2 (SUR2) is an ATP-binding cassette transporter that in humans is encoded by the ABCC9 gene.

ATP-binding cassette, sub-family A (ABC1), member 5 is a protein that in humans is encoded by the ABCA5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000243064 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "ABCC13 ATP binding cassette subfamily C member 13 (pseudogene) [ Homo sapiens (human) ]". National Center for Biotechnology Information . Retrieved 11 August 2019.

Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of Genomics and Human Genetics. 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
Annilo T, Dean M (Jul 2004). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages". Genomics. 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752 . PMID 14759258.
Brun ME, Ruault M, Ventura M, Roizès G, De Sario A (Jul 2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms". Gene. 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID 12909339.
Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T (Dec 2002). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver". Biochemical and Biophysical Research Communications. 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID 12445816.
Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi: 10.1093/hmg/5.10.1649 . PMID 8894702.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000243064 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "ABCC13 ATP binding cassette subfamily C member 13 (pseudogene) [ Homo sapiens (human) ]". National Center for Biotechnology Information . Retrieved 11 August 2019.

[1]

[2]

[3]

v t e Membrane proteins, carrier proteins: membrane transport proteins ABC-transporter (TC 3A1)
A	A1 A2 A3 A4 A7 A8 A12 A13
B	B1 B2-3 (B2 B3) B4 B5 B6 B7 B9 B11
C	C1 C2 C3 C4 C5 C6 C7 C8-9 (C8, C9) C10 C11 C13
D	D1 D2 D3 D4
E	E1
F	F1 F2
G	G1 G2 G4 Sterolin (G5, G8)
see also ABC transporter disorders

ABCC13

Contents

Function

See also

Related Research Articles

References

Further reading