CDC14B

Last updated
CDC14B
Protein CDC14B PDB 1ohc.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDC14B , CDC14B3, Cdc14B1, Cdc14B2, hcell division cycle 14B
External IDs OMIM: 603505 MGI: 2441808 HomoloGene: 104197 GeneCards: CDC14B
Orthologs
SpeciesHumanMouse
Entrez

8555

218294

Ensembl

ENSG00000081377

ENSMUSG00000033102

UniProt

O60729

Q6PFY9

RefSeq (mRNA)

NM_001122989
NM_172587

RefSeq (protein)

NP_001116461
NP_766175

Location (UCSC) Chr 9: 96.49 – 96.62 Mb Chr 13: 64.19 – 64.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene. [5] [6]

Contents

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms. [6]

Interactions and Functions

CDC14B has been shown to interact with p53, potentially de-phosphorylate p53 at Serine 315 and thereby stabilize p53. [7] S315-phosphorylated p53, in contrast to other p53 phosphorylation, was shown to facilitate p53 degradation. [8] At the patho-physiological level, mice with CDC14B deletion were shown to exhibit early-onset ageing phenotypes. [9]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000081377 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033102 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (November 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". The Journal of Biological Chemistry. 272 (47): 29403–29406. doi: 10.1074/jbc.272.47.29403 . PMID   9367992.
  6. 1 2 "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)".
  7. ↑ Li L, Ljungman M, Dixon JE (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". The Journal of Biological Chemistry. 275 (4): 2410–2414. doi: 10.1074/jbc.275.4.2410 . PMID   10644693.
  8. ↑ Li, Y; Cui K; Zhang Q; Li X; Lin X; Tang Y; Prochownik E; Li Y (July 2021). "FBXL6 degrades phosphorylated p53 to promote tumor growth". Cell Death Differ. 28 (7): 2112–2125. doi: 10.1038/s41418-021-00739-6 . ISSN   1350-9047. PMC   8257708 . PMID   33568778.
  9. ↑ Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen M, Zhang P (April 2011). "Early-onset aging and defective DNA damage response in Cdc14b-deficient mice". Mol. Cell. Biol. 31 (7): 1470–1477. doi: 10.1128/MCB.01330-10 . PMC   3135283 . PMID   21262768.

Further reading


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