CENPC1

CENPC
Identifiers
Aliases	CENPC , CENP-C, CENPC1, MIF2, hcp-4, centromere protein C
External IDs	OMIM: 117141 MGI: 99700 HomoloGene: 1371 GeneCards: CENPC
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,545,503 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,213,442 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; corpus callosum; ; bone marrow cells; ; thymus; ; body of pancreas; ; lymph node; ; endometrium; ; cervix; ; rectum;
	Top expressed in
	spermatocyte; ; otic placode; ; superior cervical ganglion; ; abdominal wall; ; saccule; ; ganglionic eminence; ; medial ganglionic eminence; ; atrioventricular valve; ; dermis; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; centromeric DNA binding ; protein binding ; identical protein binding ;
Cellular component	pericentric heterochromatin ; chromosome ; chromosome, centromeric region ; kinetochore ; nucleus ; nucleoplasm ; cytosol ; nuclear body ; midbody ; cleavage furrow ; intercellular bridge ; Flemming body ;
Biological process	chromosome segregation ; cell division ; kinetochore assembly ; cell cycle ; CENP-A containing chromatin assembly ; attachment of mitotic spindle microtubules to kinetochore ; monopolar spindle attachment to meiosis I kinetochore ; mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	1060
	12617
	ENSG00000145241
	ENSMUSG00000029253
	Q03188
	P49452
	NM_001812 ; NM_001362481
	NM_007683 ; NM_001345902 ; NM_001345903 ; NM_001345904
	NP_001803 ; NP_001349410
	NP_001332831 ; NP_001332832 ; NP_001332833 ; NP_031709
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 14, 2023

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.^[5]^[6]

Related Research Articles

Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere.

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene. CENPA is a histone H3 variant which is the critical factor determining the kinetochore position(s) on each chromosome in most eukaryotes including humans.

Centromere protein F is a protein that in humans is encoded by the CENPF gene. It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia.

Centromere-associated protein E is a protein that in humans is encoded by the CENPE gene.

Kinesin-like protein KIF2C is a protein that in humans is encoded by the KIF2C gene.

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.

Centromere protein U is a protein that in humans is encoded by the CENPU gene.

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.

Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.

Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.

Centromere protein T is a protein that in humans is encoded by the CENPT gene.

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

Centromere protein N is a protein that in humans is encoded by the CENPN gene.

DSN1, MIND kinetochore complex component, homolog , also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.

Centromere protein L is a protein that in humans is encoded by the CENPL gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145241 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029253 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics. 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.
1 2 "Entrez Gene: CENPC1 centromere protein C 1".

External links

Human CENPC genome location and CENPC gene details page in the UCSC Genome Browser .

Saitoh H, Tomkiel J, Cooke CA, et al. (1992). "CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate". Cell. 70 (1): 115–25. doi:10.1016/0092-8674(92)90538-N. PMID 1339310. S2CID 22014181.
Pluta AF, Earnshaw WC (1996). "Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator". J. Biol. Chem. 271 (31): 18767–74. doi: 10.1074/jbc.271.31.18767 . PMID 8702533.
Xie Y, Heng HH (1996). "FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21". Cytogenet. Cell Genet. 74 (3): 192–3. doi:10.1159/000134412. PMID 8941372.
Xie Y, Ni ZM, Gu JR, et al. (1997). "Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore". Cell Res. 7 (1): 13–9. doi: 10.1038/cr.1997.2 . PMID 9261558.
Pluta AF, Earnshaw WC, Goldberg IG (1998). "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death". J. Cell Sci. 111. ( Pt 14) (14): 2029–41. doi:10.1242/jcs.111.14.2029. PMID 9645950.
Song K, Gronemeyer B, Lu W, et al. (2002). "Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C)". Exp. Cell Res. 275 (1): 81–91. doi:10.1006/excr.2002.5495. PMID 11925107.
Politi V, Perini G, Trazzi S, et al. (2002). "CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains". J. Cell Sci. 115 (Pt 11): 2317–27. doi: 10.1242/jcs.115.11.2317 . PMID 12006616.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Trazzi S, Bernardoni R, Diolaiti D, et al. (2003). "In vivo functional dissection of human inner kinetochore protein CENP-C". J. Struct. Biol. 140 (1–3): 39–48. doi:10.1016/S1047-8477(02)00506-3. PMID 12490152.
Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi: 10.1074/jbc.C300407200 . PMID 14578343.
Suzuki N, Nakano M, Nozaki N, et al. (2004). "CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization". J. Biol. Chem. 279 (7): 5934–46. doi: 10.1074/jbc.M306477200 . PMID 14612452.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID 15009096. S2CID 21813024.
Chung TL, Hsiao HH, Yeh YY, et al. (2004). "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides". J. Biol. Chem. 279 (38): 39653–62. doi: 10.1074/jbc.M405637200 . PMID 15272016.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID 16716197. S2CID 45931410.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.
Faragher AJ, Sun XM, Butterworth M, et al. (2007). "Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase". Mol. Biol. Cell. 18 (4): 1337–47. doi:10.1091/mbc.E06-05-0409. PMC 1838999 . PMID 17287400.
Wong LH, Brettingham-Moore KH, Chan L, et al. (2007). "Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere". Genome Res. 17 (8): 1146–60. doi:10.1101/gr.6022807. PMC 1933521 . PMID 17623812.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000145241 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029253 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7959789-5] McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics. 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.

[entrez-6] 1 2 "Entrez Gene: CENPC1 centromere protein C 1".

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CENPC1

Contents

Related Research Articles

References

External links

Further reading