EPHA10

EPHA10
Identifiers
Aliases	EPHA10 , EPH receptor A10
External IDs	OMIM: 611123 MGI: 3586824 HomoloGene: 67804 GeneCards: EPHA10
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,765,133 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,917,800 bp
Gene ontology
Molecular function	• transferase activity ; • nucleotide binding ; • protein kinase activity ; • transmembrane-ephrin receptor activity ; • kinase activity ; • GO:0001948 protein binding ; • transmembrane receptor protein tyrosine kinase activity ; • protein tyrosine kinase activity ; • ATP binding ; • ephrin receptor activity ; • receptor tyrosine kinase ; • transmembrane signaling receptor activity ;
Cellular component	• integral component of membrane ; • membrane ; • cell membrane ; • integral component of plasma membrane ; • extracellular region ; • cytoplasm ; • neuron projection ; • receptor complex ;
Biological process	• phosphorylation ; • transmembrane receptor protein tyrosine kinase signaling pathway ; • protein phosphorylation ; • peptidyl-tyrosine phosphorylation ; • ephrin receptor signaling pathway ; • biological process ; • negative regulation of signal transduction ; • cell differentiation ; • negative regulation of apoptotic process ; • positive regulation of ERK1 and ERK2 cascade ; • axon guidance ;
	Sources:Amigo / QuickGO
Orthologs
	284656
	230735
	ENSG00000183317
	ENSMUSG00000028876
	Q5JZY3
	Q8BYG9
	NM_001004338 ; NM_001099439 ; NM_173641
	NM_001256432 ; NM_177671
	NP_001092909 ; NP_775912
	NP_001243361 ; NP_808339
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 17, 2020

EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene.^[5]

Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells.^[5] See MIM 179610 for additional background on Eph receptors and ephrins.^[6]

Related Research Articles

Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.

Ephrin-B1 is a protein that in humans is encoded by the EFNB1 gene. It is a member of the ephrin family. The encoded protein is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.

Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.

EPH receptor A2 is a protein that in humans is encoded by the EPHA2 gene.

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.

Ephrin A1 is a protein that in humans is encoded by the EFNA1 gene.

EPH receptor A4 is a protein that in humans is encoded by the EPHA4 gene.

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.

EPH receptor A3 is a protein that in humans is encoded by the EPHA3 gene.

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.

EPH receptor A5 is a protein that in humans is encoded by the EPHA5 gene.

Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene.

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.

Ephrin A3 is a protein that in humans is encoded by the EFNA3 gene.

Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.

EPH receptor A1 is a protein that in humans is encoded by the EPHA1 gene.

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.

Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183317 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028876 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.
↑ "MIM 179610". Online Mendelian Inheritance in Man. January 5, 2010. Retrieved August 6, 2013.

EPHA10

Related Research Articles

References

Further reading