aP2 is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease and the metabolic syndrome.
Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.
Ribosomal protein S6 is a component of the 40S ribosomal subunit and is therefore involved in translation. Mouse model studies have shown that phosphorylation of eS6 is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.
Mevalonate kinase is an enzyme that in humans is encoded by the MVK gene. Mevalonate kinases are found in a wide variety of organisms from bacteria to mammals. This enzyme catalyzes the following reaction:
Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).
BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.
Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.
Pantothenate kinase 4 is an enzyme that in humans is encoded by the PANK4 gene.
Serine/threonine-protein kinase H1 is an enzyme that in humans is encoded by the PSKH1 gene.
Serine/threonine-protein kinase 40 is an enzyme that in humans is encoded by the STK40 gene.
Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.
Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.
Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.
Cyclin-dependent kinase-like 2 is an enzyme that in humans is encoded by the CDKL2 gene.
Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.
Aldehyde dehydrogenase 8 family, member A1 also known as ALDH8A1 is an enzyme that in humans is encoded by the ALDH8A1 gene.
FAST kinase domain-containing protein 3 (FASTKD3) is a protein that in humans is encoded by the FASTKD3 gene on chromosome 5. This protein is part of the Fas-activated serine/threonine kinase domain (FASTKD) containing protein family, which is known for regulating the energy balance of mitochondria under stress.
The KSR2 gene is Kinase suppressor of ras 2 it is a protein that in humans is encoded by the KSR2 gene. KSR2 mutation effects in humans by obesity and because KSR2 gene reduces the ERK signaling and it reduces glucose and fatty acid oxidation. KSR2 mutation reduces the glucose and fatty acid oxidation process but it makes growth factor "Epidermal growth factor (EGF)" reaction more faster to simulate cell growth and KSR2 cause insulin resistance, KSA2 gene also regulates how the body uses the energy, and it usually causes type 2 diabetes.
Glycerol-3-phosphate acyltransferase 4 is a glycerol-3-phosphate acyltransferase that in humans is encoded by the GPAT4 gene.
