Interstate 40 (I-40) is a major east–west Interstate Highway running through the south-central portion of the United States. At a length of 2,556.61 miles (4,114.46 km), it is the third-longest Interstate Highway in the country, after I-90 and I-80. From west to east, it passes through California, Arizona, New Mexico, Texas, Oklahoma, Arkansas, Tennessee, and North Carolina. Its western end is at I-15 in Barstow, California, while its eastern end is at a concurrency of U.S. Route 117 (US 117) and North Carolina Highway 132 (NC 132) in Wilmington, North Carolina. Major cities served by the interstate include Flagstaff, Arizona; Albuquerque, New Mexico; Amarillo, Texas; Oklahoma City, Oklahoma; Little Rock, Arkansas; Memphis, Nashville, and Knoxville in Tennessee; and Asheville, Winston-Salem, Greensboro, Durham, Raleigh, and Wilmington in North Carolina.
U.S. Route 79 is a United States highway in the Southern United States. The route is officially considered and labeled as a north-south highway, but it is actually more of a diagonal northeast-southwest highway. The highway's northern/eastern terminus is in Russellville, Kentucky, at an intersection with U.S. Highway 68 and KY 80. Its southern/western terminus is in Round Rock, Texas, at an intersection with Interstate 35, ten miles (16 km) north of Austin. US 79, US 68, and Interstate 24/US 62 are the primary east–west access points for the Land Between the Lakes recreation area straddling the Kentucky/Tennessee border.
U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miami, was US 94. The highway's southern terminus is in the Brickell neighborhood of Downtown Miami at an intersection with Brickell Avenue (US 1), and its northern terminus is east of Copper Harbor, Michigan, at a modest cul-de-sac near Fort Wilkins Historic State Park at the tip of the Keweenaw Peninsula. US 41 closely parallels Interstate 75 (I-75) from Naples, Florida, all the way through Georgia to Chattanooga, Tennessee.
U.S. Route 70 or U.S. Highway 70 is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. It formerly ran from coast to coast, with the current Eastern terminus near the Atlantic Ocean in Atlantic, North Carolina, and the former Western terminus near the Pacific Ocean in Los Angeles, California. The current Western terminus is at US 60 / SR 77 in Globe, Arizona. Before the completion of the Interstate system, U.S. Highway 70 was sometimes referred to as the "Broadway of America", due to its status as one of the main east–west thoroughfares in the nation. It was also promoted as the "Treasure Trail" by the U.S. Highway 70 Association as of 1951.
U.S. Route 431 (US 431) is a spur of U.S. Route 31. It currently travels for approximately 556 miles (895 km) from US 231/Alabama State Route 210 and US 231 Business and US 431 Bus. in Dothan, Alabama, to Owensboro, Kentucky, at US 60 and Kentucky Route 2831.
State Route 1, known as the Memphis to Bristol Highway, is a 538.8-mile-long (867.1 km) mostly-unsigned state highway in the U.S. state of Tennessee. It stretches all the way from the Arkansas state line at Memphis in the southwest corner of the state to Bristol in the northeast part. Most of the route travels concurrently with U.S. Route 70 and US 11W. It is the longest highway of any kind in the state of Tennessee. The route is signed as both in the state of Tennessee, a Primary and Secondary Highway
State Route 14 is a south–north route from the Mississippi border in Memphis, Tennessee to an intersection with State Route 54 in Tipton County.
State Route 52 is an east–west state highway that crosses eight counties in northern and northeastern Tennessee. The 141.4-mile-long (227.6 km) route originates in Orlinda along SR 49 and ends in Elgin along U.S. Route 27.
State Route 12 is a highway from Davidson County, Tennessee to Montgomery County, Tennessee.
Interstate 65 (I-65) runs from Ardmore north in Tennessee to just south of Franklin, Kentucky, forming part of the national highway that goes from Mobile, Alabama, to Gary, Indiana. In Tennessee the highway's official name is the Albert Arnold Gore Sr. Memorial Highway, named for Albert Gore Sr., the former US Senator.
U.S. Route 70 Alternate is a 61.7-mile-long (99.3 km) alternate route to US 70 between Brownsville, and Huntingdon in West Tennessee. Signage along this route, and on most maps, show it as US 70A and not US 70 Alternate.
State Route 13, in the United States, is a south–north route from the Alabama border in Wayne County to the Kentucky border in Montgomery County. The entire route is located in western Middle Tennessee.
State Route 76 (SR 76) is a state highway in Tennessee, traversing the state in a northeast-southwest axis from east of Memphis to north of Nashville. SR 76 is unique in that it actually changes its cardinal directions in Clarksville at the junction with US 41A and US 41A Bypass.
U.S. Route 70 enters the state of Tennessee from Arkansas via the Memphis & Arkansas Bridge in Memphis, and runs west to east across 21 counties in all three grand divisions of Tennessee, with a total length of 478.48 miles (770.04 km), to end at the North Carolina state line in eastern Cocke County. Along the route, US 70 is accompanied with various U.S. and state highways, including those in three of the state's four major cities.
In Tennessee, U.S. Route 64 stretches 404.1 miles (650.3 km) from the Mississippi River in Memphis to the North Carolina state line near Ducktown. The highway, along with US 72, is a major route for travel between Memphis and Chattanooga.
U.S. Route 431 in Tennessee totals an estimated 116 miles (187 km) through Lincoln, Marshall, Maury, Williamson, Davidson, and Robertson Counties in Middle Tennessee.
Several special routes of U.S. Route 41 exist, including three in Wisconsin. In order from south to north they are as follows.
State Route 54 is a west–east rural highway in West Tennessee, which runs from Covington to just north of Paris.
U.S. Route 41 Alternate, also signed U.S. Route 41A in Tennessee (US 41A), connects the town of Monteagle, Tennessee, with Hopkinsville, Kentucky, 10 miles (16 km) north of the Tennessee line. It serves the city of Clarksville, Tennessee, on its way to Nashville, where it briefly runs concurrently with US 41. It then separates again to serve Shelbyville, Winchester, and Tullahoma before rejoining the main route atop Monteagle Mountain. US 41A runs west of US 41 for its entire length, aside from one mile in downtown Nashville where they are concurrent. US 41A is also concurrent with U.S. Route 31A from Nashville to Triune, Tennessee, for a distance of approximately 25 miles (40 km).
State Route 77 (SR 77), is an east–west state highway in the U.S. state of Tennessee. The 84.86-mile-long (136.57 km) route traverses the flat farmland of West Tennessee.
I-55 / US 61 / US 64 / US 70 / US 79 at the Arkansas state line/Mississippi River in Memphis 
I-24 (Exit 4) in Clarksville
US 79 at the Kentucky state line northeast of Clarksville 
