| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Chimeric (mouse/human) |
| Target | VAP-1 |
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Vapaliximab is a chimeric monoclonal antibody [1] and an experimental immunosuppressive drug.[ citation needed ] Development was discontinued by 2012. [2]
Cocaine, also known as coke, is a strong stimulant most frequently used as a recreational drug. It is commonly snorted, inhaled as smoke, or dissolved and injected into a vein. Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation. Physical symptoms may include a fast heart rate, sweating, and large pupils. High doses can result in very high blood pressure or body temperature. Effects begin within seconds to minutes of use and last between five and ninety minutes. Cocaine has a small number of accepted medical uses, such as numbing and decreasing bleeding during nasal surgery.
3,4-Methyl
The United States Food and Drug Administration is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, animal foods & feed and veterinary products.
Heroin, also known as diacetylmorphine and diamorphine among other names, is an opioid used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt which is distinguished from black tar heroin, a variable admixture of morphine derivatives—predominantly 6-MAM (6-monoacetylmorphine), which is the result of crude acetylation during clandestine production of street heroin. Diamorphine is used medically in several countries to relieve pain, such as during childbirth or a heart attack, as well as in opioid replacement therapy. It is typically injected, usually into a vein, but it can also be smoked, snorted, or inhaled. In a clinical context the route of administration is most commonly intravenous injection; it may also be given by intramuscular or subcutaneous injection, as well as orally in the form of tablets. The onset of effects is usually rapid and lasts for a few hours.
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a hallucinogenic drug. Effects typically include altered thoughts, feelings, and awareness of one's surroundings. Many users have visual or auditory hallucinations. Dilated pupils, increased blood pressure, and increased body temperature are typical. Effects typically begin within half an hour and can last for up to 12 hours. It is used mainly as a recreational drug or for spiritual reasons.
Pharmacology is a branch of medicine and pharmaceutical sciences which is concerned with the study of drug or medication action, where a drug can be broadly or narrowly defined as any man-made, natural, or endogenous molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals.
Fentanyl, also spelled fentanil, is an opioid used as a pain medication and together with other medications for anesthesia. It is also used as a recreational drug, often mixed with heroin or cocaine. It has a rapid onset and its effects generally last under two hours. Medically, it is used by injection, nasal spray, skin patch, or absorbed through the cheek (transmucosal) as a lozenge or tablet.
Methaqualone is a sedative and hypnotic medication. It was sold under the brand names Quaalude and Sopor among others, which contained 300mg of methaqualone, and sold as a combination drug under the brand name Mandrax which contained 250mg methaqualone and 25mg diphenhydramine within the same tablet, though mostly in Europe. Commercial production of methaqualone was halted in the mid 1980s due to widespread abuse and addictiveness. It is a member of the quinazolinone class.
A medication is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management.
The illegal drug trade or drug trafficking is a global, black market dedicated to the cultivation, manufacture, distribution and sale of drugs that are subject to drug prohibition. Most jurisdictions prohibit trade, except under license, of many types of drugs through the use of drug prohibition laws.
Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that typically produces a calming effect. It is commonly used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, benzodiazepine withdrawal syndrome, muscle spasms, trouble sleeping, and restless legs syndrome. It may also be used to cause memory loss during certain medical procedures. It can be taken by mouth, inserted into the rectum, injected into muscle, injected into a vein or used as a nasal spray. When given into a vein, effects begin in one to five minutes and last up to an hour. By mouth, effects begin after 15 to 60 minutes.
Ivermectin is a medication used to treat many types of parasite infestations. This includes head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis. It can be taken by mouth or applied to the skin for external infestations.
The war on drugs is a global campaign, led by the U.S. federal government, of drug prohibition, military aid, and military intervention, with the aim of reducing the illegal drug trade in the United States. The initiative includes a set of drug policies that are intended to discourage the production, distribution, and consumption of psychoactive drugs that the participating governments and the UN have made illegal. The term was popularized by the media shortly after a press conference given on June 18, 1971, by President Richard Nixon—the day after publication of a special message from President Nixon to the Congress on Drug Abuse Prevention and Control—during which he declared drug abuse "public enemy number one". That message to the Congress included text about devoting more federal resources to the "prevention of new addicts, and the rehabilitation of those who are addicted", but that part did not receive the same public attention as the term "war on drugs". However, two years prior to this, Nixon had formally declared a "war on drugs" that would be directed toward eradication, interdiction, and incarceration. Today, the Drug Policy Alliance, which advocates for an end to the War on Drugs, estimates that the United States spends $51 billion annually on these initiatives.
Cannabis, also known as marijuana among other names, is a psychoactive drug from the Cannabis plant used primarily for medical or recreational purposes. Tetrahydrocannabinol (THC) is the main psychoactive component of cannabis, which is one of the 483 known compounds in the plant, including at least 65 other cannabinoids, including cannabidiol (CBD). Cannabis can be used by smoking, vaporizing, within food, or as an extract.
Joaquín Archivaldo Guzmán Loera, commonly known as "El Chapo" because of his 168 cm stature, is a Mexican drug lord and former leader of the Sinaloa Cartel, an international crime syndicate. He is considered to have been the most powerful drug trafficker in the world.
The Mexican drug war is the Mexican theater of the global war on drugs, as led by the U.S. federal government, that has resulted in an ongoing asymmetric low-intensity conflict between the Mexican government and various drug trafficking syndicates. When the Mexican military began to intervene in 2006, the government's principal goal was to reduce drug-related violence. The Mexican government has asserted that their primary focus is on dismantling the powerful drug cartels, and on preventing drug trafficking demand along with the U.S. functionaries.
A drug is any substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue.
Methamphetamine is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms. It is rarely prescribed over concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy. Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine.
The Sinaloa Cartel, also known as the CDS, the Guzmán-Loera Organization, the Pacific Cartel, the Federation and the Blood Alliance, is a large international drug trafficking, money laundering, and organized crime syndicate established during the late 1980s. The cartel is primarily based in the city of Culiacán, Sinaloa, with operations in the Mexican states of Baja California, Durango, Sonora, and Chihuahua. The "Federation" was partially splintered when the Beltrán-Leyva brothers broke apart from the Sinaloa Cartel. The Mexican and U.S. Government both consider the Sinaloa Cartel to be "the largest and most powerful drug cartel of all time", making it perhaps even more influential and capable than the famed Medellín Cartel of Colombia during its prime in the 1980s and early 1990s. The United States Intelligence Community considers the Sinaloa Cartel to be "the most powerful criminal organization in North America". It has repeatedly been said to be one of the strongest criminal organizations and the most powerful in Mexico since at least the late 2000s and early 2010s by various sources including the Los Angeles Times.
A barbiturate is a drug that acts as a central nervous system depressant. Barbiturates are effective as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as well as overdose potential among other possible adverse effects. They have largely been replaced by benzodiazepines and nonbenzodiazepines ("Z-drugs") in routine medical practice, particularly in the treatment of anxiety and insomnia, due to the significantly lower risk of addiction and overdose and the lack of an antidote for barbiturate overdose. Despite this, barbiturates are still in use for various purposes: in general anesthesia, epilepsy, treatment of acute migraines or cluster headaches, acute tension headaches, euthanasia, capital punishment, and assisted suicide.
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