Keratin 10

KRT10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F1Z, 3ASW, 4ZRY
Identifiers
Aliases	KRT10 , BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDs	OMIM: 148080; MGI: 96685; GeneCards: KRT10; OMA:KRT10 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,822,614 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,280,190 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vulva; ; nipple; ; human penis; ; skin of hip; ; skin of abdomen; ; gums; ; gingival epithelium; ; sperm;
	Top expressed in
	skin of external ear; ; lip; ; condyle; ; skin of abdomen; ; belly cord; ; skin of back; ; human fetus; ; fossa; ; saccule; ; otic placode;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity ; structural constituent of skin epidermis ; protein heterodimerization activity ; protein binding ;
Cellular component	cytoplasm ; extracellular exosome ; intermediate filament ; membrane ; nucleus ; extracellular space ; cytosol ; cornified envelope ; extracellular region ; cell surface ;
Biological process	keratinocyte differentiation ; keratinization ; cornification ; peptide cross-linking ; positive regulation of epidermis development ; protein heterotetramerization ;
	Sources:Amigo / QuickGO
Orthologs
	3858
	16661
	ENSG00000186395
	ENSMUSG00000019761
	P13645
	P02535
	NM_000421 ; NM_001379366
	NM_010660
	NP_000412 ; NP_001366295
	NP_034790
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 15, 2024

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.^[5]^[6]^[7] Keratin 10 is a type I keratin.

Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.^[7]

Interactions

Keratin 10 has been shown to interact with AKT1.^[8]

Related Research Articles

Keratin 1 is a Type II intermediate filament (IFs) of the intracytoplasmatic cytoskeleton. Is co-expressed with and binds to Keratin 10, a Type I keratin, to form a coiled coil heterotypic keratin chain. Keratin 1 and Keratin 10 are specifically expressed in the spinous and granular layers of the epidermis. In contrast, basal layer keratinocytes express little to no Keratin 1. Mutations in KRT1, the gene encoding Keratin 1, have been associated with variants of the disease bullous congenital ichthyosiform erythroderma in which the palms and soles of the feet are affected. Mutations in KRT10 have also been associated with bullous congenital ichthyosiform erythroderma; however, in patients with KRT10 mutations the palms and soles are spared. This difference is likely due to Keratin 9, rather than Keratin 10, being the major binding partner of Keratin 1 in acral keratinocytes.

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.

Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene.

Type II keratins constitutes the Type II intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. The type 2 cytokeratins consist of basic or neutral, high molecular weight proteins which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues. It has been seen that Type II Keratins are developed before Type 1 keratins during human embryonic development.

Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined. Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene.

Keratin 9 is a protein that in humans is encoded by the KRT9 gene.

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.

Collagen XVII, previously called BP180, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion, identified by Diaz and colleagues in 1990.

Laminin subunit beta-3 is a protein that in humans is encoded by the LAMB3 gene.

Loricrin is a protein that in humans is encoded by the LOR gene.

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186395 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019761 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM (Jan 1989). "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol. 91 (6): 572–8. doi: 10.1111/1523-1747.ep12477087 . PMID 2461420.
↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.
1 2 "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)".
↑ Paramio, J M; Segrelles C; Ruiz S; Jorcano J L (Nov 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. 21 (21). United States: 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMC 99917 . PMID 11585925.

Yang JM, Nam K, Kim SW, et al. (1999). "Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis". J. Dermatol. Sci. 19 (2): 126–33. doi:10.1016/S0923-1811(98)00055-3. PMID 10098704.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
Korge BP, Gan SQ, McBride OW, et al. (1992). "Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops". Proc. Natl. Acad. Sci. U.S.A. 89 (3): 910–4. Bibcode:1992PNAS...89..910K. doi: 10.1073/pnas.89.3.910 . PMC 48354 . PMID 1371013.
Tkachenko AV, Buchman VL, Bliskovsky VV, et al. (1992). "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats". Gene. 116 (2): 245–51. doi:10.1016/0378-1119(92)90521-P. PMID 1378806.
Rothnagel JA, Dominey AM, Dempsey LD, et al. (1992). "Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis". Science. 257 (5073): 1128–30. Bibcode:1992Sci...257.1128R. doi:10.1126/science.257.5073.1128. PMID 1380725. S2CID 30648935.
Cheng J, Syder AJ, Yu QC, et al. (1992). "The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes". Cell. 70 (5): 811–9. doi:10.1016/0092-8674(92)90314-3. PMID 1381287. S2CID 31906051.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Nazzaro V, Ermacora E, Santucci B, Caputo R (1990). "Epidermolytic hyperkeratosis: generalized form in children from parents with systematized linear form". Br. J. Dermatol. 122 (3): 417–22. doi:10.1111/j.1365-2133.1990.tb08292.x. PMID 2182100. S2CID 9344745.
Darmon MY, Sémat A, Darmon MC, Vasseur M (1988). "Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression". Mol. Biol. Rep. 12 (4): 277–83. doi:10.1007/BF00444680. PMID 2448602. S2CID 4322605.
Zhou XM, Idler WW, Steven AC, et al. (1988). "The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences". J. Biol. Chem. 263 (30): 15584–9. doi: 10.1016/S0021-9258(19)37628-8 . PMID 2459124.
Rieger M, Franke WW (1989). "Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10". J. Mol. Biol. 204 (4): 841–56. doi:10.1016/0022-2836(88)90045-9. PMID 2464696.
van Dongen GA, Braakhuis BJ, Leyva A, et al. (1989). "Anti-tumor and differentiation-inducing activity of N,N-dimethylformamide (DMF) in head-and-neck cancer xenografts". Int. J. Cancer. 43 (2): 285–92. doi:10.1002/ijc.2910430221. PMID 2465278. S2CID 22052183.
Rogaev EI, Rogaeva EA, Ginter EK, et al. (1994). "Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes". Nat. Genet. 5 (2): 158–62. doi:10.1038/ng1093-158. PMID 7504553. S2CID 9295678.
Rothnagel JA, Longley MA, Holder RA, et al. (1994). "Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing". J. Invest. Dermatol. 102 (1): 13–6. doi: 10.1111/1523-1747.ep12371723 . PMID 7507150.
McLean WH, Eady RA, Dopping-Hepenstal PJ, et al. (1994). "Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)". J. Invest. Dermatol. 102 (1): 24–30. doi: 10.1111/1523-1747.ep12371726 . PMID 7507152.
Chipev CC, Yang JM, DiGiovanna JJ, et al. (1994). "Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis". Am. J. Hum. Genet. 54 (2): 179–90. PMC 1918158 . PMID 7508181.
Rothnagel JA, Fisher MP, Axtell SM, et al. (1994). "A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis" (PDF). Hum. Mol. Genet. 2 (12): 2147–50. doi:10.1093/hmg/2.12.2147. PMID 7509230.
Syder AJ, Yu QC, Paller AS, et al. (1994). "Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity". J. Clin. Invest. 93 (4): 1533–42. doi:10.1172/JCI117132. PMC 294170 . PMID 7512983.
Huber M, Scaletta C, Benathan M, et al. (1994). "Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations". J. Invest. Dermatol. 102 (5): 691–4. doi: 10.1111/1523-1747.ep12374270 . PMID 7513736.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186395 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2461420-5] Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM (Jan 1989). "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol. 91 (6): 572–8. doi: 10.1111/1523-1747.ep12477087 . PMID 2461420.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177 . PMID 16831889.

[entrez-7] 1 2 "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)".

[pmid11585925-8] Paramio, J M; Segrelles C; Ruiz S; Jorcano J L (Nov 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. 21 (21). United States: 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMC 99917 . PMID 11585925.

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Keratin 10

Contents

Function

Interactions

See also

Related Research Articles

References

Further reading