Organoberyllium chemistry

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Crystal structure of a .mw-parser-output .template-chem2-su{display:inline-block;font-size:80%;line-height:1;vertical-align:-0.35em}.mw-parser-output .template-chem2-su>span{display:block;text-align:left}.mw-parser-output sub.template-chem2-sub{font-size:80%;vertical-align:-0.35em}.mw-parser-output sup.template-chem2-sup{font-size:80%;vertical-align:0.65em} BePh2 compound. Crystal Structure of a BePh2 Complex that produce dimers.png
Crystal structure of a BePh2 compound.

Organoberyllium chemistry involves the synthesis and properties of organometallic compounds featuring the group 2 alkaline earth metal beryllium (Be). The area remains understudied, relative to the chemistry of other main-group elements, because although metallic beryllium is relatively unreactive, its dust causes berylliosis and compounds are toxic. [1] Organoberyllium compounds are typically prepared by transmetallation or alkylation of beryllium chloride. [2]

Contents

The beryllium functional group in organoberyllium compounds usually serves to coordinate other elements and ligands. Beryllium, one of the smallest atoms on the periodic table, almost always exhibits a +2 oxidation state. [3] The Be2+ cation is characterized by the highest known charge density (Z/r = 6.45), making it one of the hardest cations and a very strong Lewis acid. [4]

Coordination in beryllium can range from a coordination number of two to four. [5] Most common ligands attached to beryllium are halides, hydride (like beryllium borohydride in a three-center two-electron bond), methyl, aryl, and alkyl. Beryllium can form complexes with known organic compounds such as phosphines, N-hetereocyclic carbenes (NHC), cyclic alkyl amino carbenes (CAAC), and β-diketiminates (NacNac).

General characteristics

Organoberyllium chemistry is limited to academic research due to the cost and toxicity of beryllium.

Organoberyllium compounds consist of a beryllium atom with an organic group attached. There are very few reported case of Be(I) and Be(0) oxidation states. [6] [7] [8] Instead, Be has a +2 oxidation state, and higher charge density than any other group 2 element. Organometallic beryllium compounds are highly reactive strong acids. Beryllium has a high electronegativity compare to other group 2 elements; thus the resulting C-Be bonds are less highly polarized than other C-MII bonds, [9] although the attached carbon still bears a negative dipole moment.

Lighter organoberyllium compounds are often considered covalent, but with some ionic bond characteristics. From this perspective, the C-Be bonds are much more ionic and highly polarized than other C-R bonds. This higher ionic character and bond polarization tends to produce high coordination numbers. Many compounds, particularly dialklys, are polymeric in solid or liquid states with highly complex structures in solution; in the gaseous state, they often revert to monomers. A good example is beryllium borohydride, which dimerizes to form three-center two-electron bonds.

Beryllium borohydride compound that creates a three center two electron bond. Beryllium Borohyride Complex.png
Beryllium borohydride compound that creates a three center two electron bond.

Compounds such as these hydrides can coordinate with carbenes such as N-heterocyclic carbene to form crystals. The propensity for co-crystallization suggests applications in organocatalysis.

Compounds

Beryllium can form a variety of organoberyllium compounds, including ring structures, alkyls, alkynyls, [10] hydrides, [11] [12] methyls, halides, phosphines, carbenes, and nitrogen-based coordination such as NacNac.

Dimethylberyllium has the same crystal structure as dimethylmagnesium [13] and can be used to synthesize beryllium azide and beryllium hydride.

Ring structure

Organoberyllium structures can consist of an aryl, [14] dineopentylberyllium, [14] beryllocene, [15] [16] [17] phenyl, [18] or terphenyl. [19]

Halides

Beryllium halides are formed by a combination of halogen with a beryllium atom. Beryllium halides are mostly covalent in nature except for the fluoride which is more ionic. They can be used as Lewis acid catalysts. Preparation for these compounds varies by the halogen. Beryllium halides are among the most common starting points to form complexes with other types of ligand. [20] [2] Halides can donate 2 electrons into the beryllium center with a charge of −1.

Phosphines

Organoberyllium phosphines are another class of compounds that is used in synthesis. [21] Phosphine donates two electrons into the beryllium center. Phosphines are L-type ligands. Unlike most metal ammine complexes, metal phosphine complexes tend to be lipophilic, displaying good solubility in organic solvents. Phosphine ligands are also π-acceptors. Their π-acidity arises from overlap of P-C σ* anti-bonding orbitals with filled metal orbitals. Beryllium can coordinate with a phosphine due to its good π-acceptor ability, which is used extensively in beryllium chemistry literature. An organoberyllium phosphine can be prepared through coordination with a beryllium halide to form a four-coordinate tetrahedral compound.

Phosphine type coordination with a Be Halide Complex Phosphine Coordination with a BeCl2 Complex.png
Phosphine type coordination with a Be Halide Complex

Carbenes

An organoberyllium carbene consists of a carbene attached to beryllium. The types of carbene includes a N-heterocyclic carbenes (NHC) and cyclic alkyl amino carbenes (CAAC).

N-Hetereocyclic carbenes

Beryllium can coordinate with an N-hetereocyclic carbene (NHC). [22] [23] [24] NHCs are defined as heterocyclic species containing a carbene carbon and at least one nitrogen atom within the ring structure. [21] NHCs have found numerous applications in some of the most important catalytic transformations in chemical industry, but their reactivity in coordinating with main group elements especially with beryllium’s potential as a reactive organocatalyst has opened new areas of research. [25]

Coordination with a NHC ligand to a Be complex with R not limited to halogen, hydride, phosphine, aryl, alkyl etc. Example of a N-Hetereocyclic Carbene with a Beryllium Center.png
Coordination with a NHC ligand to a Be complex with R not limited to halogen, hydride, phosphine, aryl, alkyl etc.

Cyclic alkyl amino carbenes (CAAC)

Beryllium can coordinate with cyclic alkyl amino carbene (CAAC) ligands and can form beryllium radicals which can be present with beryllium complexes (BeR2). A CAAC ligand coordinates a 2 electron -1 charge into the beryllium center. [26] CAAC has an "amino" substituent and an "alkyl" sp3 carbon atom. CAACs are very good σ donors (higher HOMO) and π acceptors (lower LUMO) compared to NHCs. In addition, the lower heteroatom stability of the carbene center in CAAC compared to NHC results in a lower ΔE.

Coordination of a CAAC ligand to a Be complex with R not limited for coordination with Be A Be coordination with a CAAC Ligand.png
Coordination of a CAAC ligand to a Be complex with R not limited for coordination with Be

β-Diketiminates (NacNac)

β-Diketiminates (BDI, also known as NacNac), are a commonly used class of supporting ligands that have been successfully adopted to stabilize an extensive range of metal ions from the s, p, d, and f-blocks in multiple oxidation states. [27] The popularity of these monoanionic N-donor ligands can be explained by their convenient access and high stereoelectronic coordination. This enables the separation of highly reactive coordinatively unsaturated complexes. Moreover, studies have demonstrated the utility of this class of ligands for designing active catalysts for various transformations. So, because of that, beryllium can properly coordinate with β-diketiminate compounds due to the high reactivity and stereo electronic coordination with the beryllium thus a Be NacNac compound is also common in organoberyllium chemistry.

Example of a NacNac ligand coordination to a beryllium compound with L varies towards the reaction and number of equivalents. Nacnac Ligand using a Beryllium example Structure.png
Example of a NacNac ligand coordination to a beryllium compound with L varies towards the reaction and number of equivalents.

Synthesis

Synthesis of organoberyllium compounds is limited but literature have shown that beryllium can react with halides, alkyls, alloxides and other organic compounds. Alkylation of beryllium halide is one of the most widely-used method in beryllium chemistry. [28]

Transmetallation

A transmetallation involves a ligand transfer to one another such as this:

MR2 + Be → BeR2 + M

M is not limited to any main group and/or transition metal. R can be limited to almost any phosphine, aryl, alkyl, halogen, hydrogen and/or carbene.

In this case organoberyllium can form reactions such as:

A synthesis of a BePh2, which forms a crystal structure from this reaction. Tranmetellation Reaction with Be.png
A synthesis of a BePh 2, which forms a crystal structure from this reaction.

Alkylation

This structure shows a Cp2Be. The solid-state structure suggests that the two rings are bound to the beryllium differently such that one is designated e and the other e Beryllocene conformation.svg
This structure shows a Cp 2Be. The solid-state structure suggests that the two rings are bound to the beryllium differently such that one is designated η and the other η

Alkylation of beryllium halide is another common method to react to make an organoberyllium compound such as this:

2 MR1 + BeR22 → BeR12 + 2 MR22

M is not limited to any main group and/or transition metal. R1 is not limited to phenyl, methyl, methyl oxide, carbene etc. R2 can be any halide such as fluoride, bromide, iodide, or chloride.

An example of such reaction is the synthesis of bis(cyclopentadienyl)beryllium ( Cp 2Be) or beryllocene from BeCl2 and potassium cyclopentadienide:

2 K[Cp] + BeCl2 → [Cp]2Be + 2 KCl

Low oxidation beryllium chemistry

While Be(II) is one of the more common oxidation states, there is also further research on a Be(I) and Be(0) complex. Low-valent main group compounds have recently become desirable synthetic targets due to their interesting reactivity comparable to transition metal complexes. In one work, stabilized cyclic (alkyl)(amino)carbene ligands were used to isolate and characterize the first neutral compounds containing beryllium, with the Be(0) compound stabilized by a strongly σ-donating and π-accepting cyclic CAAC ligand. [29]

This reaction is shown when a CAAC ligand is coordinated with a BeCl2 and using KC8 to form a zero oxidation beryllium complex. This work was done by Prof Braunschweig to create the first neutral Be complex the R group includes Me and (CH2)5 and Dipp is otherwise known as 2,6-diisopropylphenyl. Be (0) Complex Synthesis.png
This reaction is shown when a CAAC ligand is coordinated with a BeCl2 and using KC8 to form a zero oxidation beryllium complex. This work was done by Prof Braunschweig to create the first neutral Be complex the R group includes Me and (CH2)5 and Dipp is otherwise known as 2,6-diisopropylphenyl.

Be(I) is another example of a rare phenomenon and few publications were reported, but one example of a Be(I) was a CAAC ligand already coordinated with Be. Gilliard and his group created a more stable beryllium radical cation. [6] Because of well-established challenges concerning the reduction of Be(II) to Be(I), they pursued the radical via an oxidation strategy using TEMPO ((2,2,6,6-Tetramethylpiperidin-1-yl) oxyl). This reaction resulted in a Be(I) compound just by stabilizing the Be radical.

Reaction shown is radical cation reaction from a Be(II) CAAC compound to a Be(I) CAAC compound. Be (I) Complex.png
Reaction shown is radical cation reaction from a Be(II) CAAC compound to a Be(I) CAAC compound.

See also

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References

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  21. 1 2 Buchner, Magnus R.; Müller, Matthias; Rudel, Stefan S. (2017-01-19). "Beryllium Phosphine Complexes: Synthesis, Properties, and Reactivity of (PMe 3 ) 2 BeCl 2 and (Ph 2 PC 3 H 6 PPh 2 )BeCl 2". Angewandte Chemie International Edition. 56 (4): 1130–1134. doi:10.1002/anie.201610956. PMID   28004465.
  22. ↑ Paparo, Albert; Best, Stephen P.; Yuvaraj, K.; Jones, Cameron (2020-12-14). "Neutral, Anionic, and Paramagnetic 1,3,2-Diazaberyllacyles Derived from Reduced 1,4-Diazabutadienes". Organometallics. 39 (23): 4208–4213. doi:10.1021/acs.organomet.0c00017. ISSN   0276-7333. S2CID   213828903.
  23. ↑ Gilliard, Robert J.; Abraham, Mariham Y.; Wang, Yuzhong; Wei, Pingrong; Xie, Yaoming; Quillian, Brandon; Schaefer, Henry F.; Schleyer, Paul v. R.; Robinson, Gregory H. (2012-06-20). "Carbene-Stabilized Beryllium Borohydride". Journal of the American Chemical Society. 134 (24): 9953–9955. doi:10.1021/ja304514f. ISSN   0002-7863. PMID   22670857.
  24. ↑ Paparo, Albert; Jones, Cameron (2019-01-03). "Beryllium Halide Complexes Incorporating Neutral or Anionic Ligands: Potential Precursors for Beryllium Chemistry". Chemistry: An Asian Journal. 14 (3): 486–490. doi:10.1002/asia.201801800. ISSN   1861-4728. PMID   30604490. S2CID   58632466.
  25. ↑ Hopkinson, Matthew N.; Richter, Christian; Schedler, Michael; Glorius, Frank (2014-06-25). "An overview of N-heterocyclic carbenes". Nature. 510 (7506): 485–496. Bibcode:2014Natur.510..485H. doi:10.1038/nature13384. ISSN   1476-4687. PMID   24965649. S2CID   672379.
  26. ↑ Schuster, Julia K.; Roy, Dipak Kumar; Lenczyk, Carsten; Mies, Jan; Braunschweig, Holger (2019-02-18). "New Outcomes of Beryllium Chemistry: Lewis Base Adducts for Salt Elimination Reactions". Inorganic Chemistry. 58 (4): 2652–2658. doi:10.1021/acs.inorgchem.8b03263. ISSN   0020-1669. PMID   30707568. S2CID   73424673.
  27. ↑ Camp, Clément; Arnold, John (2016-09-20). "On the non-innocence of "Nacnacs": ligand-based reactivity in β-diketiminate supported coordination compounds". Dalton Transactions. 45 (37): 14462–14498. doi:10.1039/C6DT02013E. ISSN   1477-9234. PMID   27353604.
  28. ↑ Coates, G. E.; Morgan, G. L. (1971-01-01), Stone, F. G. A.; West, Robert (eds.), Organoberyllium Compounds, Advances in Organometallic Chemistry, vol. 9, Academic Press, pp. 195–257, doi:10.1016/S0065-3055(08)60052-0, ISBN   9780120311095 , retrieved 2022-11-08
  29. ↑ Arrowsmith, Merle; Braunschweig, Holger; Celik, Mehmet Ali; Dellermann, Theresa; Dewhurst, Rian D.; Ewing, William C.; Hammond, Kai; Kramer, Thomas; Krummenacher, Ivo; Mies, Jan; Radacki, Krzysztof; Schuster, Julia K. (2016-06-06). "Neutral zero-valent s-block complexes with strong multiple bonding". Nature Chemistry. 8 (9): 890–894. Bibcode:2016NatCh...8..890A. doi:10.1038/nchem.2542. ISSN   1755-4349. PMID   27334631.
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