Wilson's temperature syndrome

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Wilson's temperature syndrome
Pseudomedical diagnosis
Risks Nocebo

Wilson's (temperature) syndrome, also called Wilson's thyroid syndrome or WTS, is a term used in alternative medicine to improperly attribute various common and non-specific symptoms to abnormally low body temperature and impaired conversion of thyroxine (T4) to triiodothyronine (T3), despite normal thyroid function tests. [1] E. Denis Wilson, a physician who invented the concept and named it after himself, treated these symptoms with sustained-release triiodothyronine (SR-T3) until one of his patients died and he was banned from prescribing this treatment any longer.

Contents

Wilson's Syndrome is not an actual medical condition, and medical expert groups have warned against it as a potentially dangerous misunderstanding of physiology. The American Thyroid Association (ATA) released an official statement asserting that Wilson's syndrome is at odds with established knowledge of thyroid function and describing the diagnostic criteria for Wilson's syndrome as "imprecise" and "non-specific". [2]

After one of Wilson's patients died from his treatment in 1988, Florida State Medical Board members described Wilson's temperature syndrome as a "phony syndrome" and as a scam that fleeced patients and healthcare insurers during disciplinary action against Wilson, whose medical license was suspended for six months. [3]

Origin and claims

The term Wilson’s syndrome was coined in 1990 by E. Denis Wilson, a physician practicing in Longwood, Florida. He claimed that fatigue, headaches, PMS, hair loss, irritability, fluid retention, depression, decreased memory, low sex drive, unhealthy nails, and easy weight gain were manifestation of this eponymous syndrome. Wilson claims that it is one of "the most common of all chronic ailments and probably takes a greater toll on society than any other medical condition." [4]

He claimed that low thyroid symptoms and low body temperatures in the presence of normal thyroid function tests are common. To distinguish his alternative concept from conventional, evidence-based hypothyroidism, he named his concept Wilson's (temperature) syndrome. The main diagnostic sign is an oral body temperature that averages well below 37.0 °C (98.6 °F). This overlaps with normal body temperature, which is usually within the range of 36.5–37.5 °C (97.7–99.5 °F). [5] [6] Wilson says that his diagnosis is confirmed if the patient responds to treatment with slow-release T3 (SR-T3).

Patient death and medical license suspension

In 1988, one of Wilson’s patients died at the age of 50 from an arrhythmia and heart attack after ingesting excessive amounts of oral thyroid hormone. [7]

Four years later, in 1992, the Florida Board of Medicine took disciplinary action against Wilson, [8] [9] accusing him of "fleecing" patients with a "phony diagnosis" and dangerous treatments. [3] [10] The Board of Medicine and Wilson settled the disciplinary action, agreeing to a 6-month suspension of Wilson's medical license, after which Wilson would need to attend 100 hours of continuing medical education, submit to psychological testing, and pay a $10,000 fine before resuming practice. Wilson also agreed not to prescribe thyroid medication to anyone unless the Board of Medicine determined that the medical community had accepted Wilson's concept and treatment as valid.

See also

Related Research Articles

<span class="mw-page-title-main">Thyroid</span> Endocrine gland in the neck; secretes hormones that influence metabolism

The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans, it is in the neck and consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the isthmus (pl.: isthmi). The thyroid gland is a butterfly-shaped gland located in the neck below the Adam's apple. Microscopically, the functional unit of the thyroid gland is the spherical thyroid follicle, lined with follicular cells (thyrocytes), and occasional parafollicular cells that surround a lumen containing colloid. The thyroid gland secretes three hormones: the two thyroid hormones – triiodothyronine (T3) and thyroxine (T4) – and a peptide hormone, calcitonin. The thyroid hormones influence the metabolic rate and protein synthesis and growth and development in children. Calcitonin plays a role in calcium homeostasis. Secretion of the two thyroid hormones is regulated by thyroid-stimulating hormone (TSH), which is secreted from the anterior pituitary gland. TSH is regulated by thyrotropin-releasing hormone (TRH), which is produced by the hypothalamus.

<span class="mw-page-title-main">Hypothyroidism</span> Endocrine disease

Hypothyroidism is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormones. It can cause a number of symptoms, such as poor ability to tolerate cold, a feeling of tiredness, constipation, slow heart rate, depression, and weight gain. Occasionally there may be swelling of the front part of the neck due to goitre. Untreated cases of hypothyroidism during pregnancy can lead to delays in growth and intellectual development in the baby or congenital iodine deficiency syndrome.

Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone produced by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid.

<span class="mw-page-title-main">Triiodothyronine</span> Chemical compound

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

<span class="mw-page-title-main">Thyroid hormone resistance</span> Medical condition

Thyroid hormone resistance (also resistance to thyroid hormone (RTH), and sometimes Refetoff syndrome) describes a rare syndrome in which the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or not completely suppressed as would be expected. The first report of the condition appeared in 1967. Essentially this is decreased end organ responsiveness to thyroid hormones. A new term "impaired sensitivity to thyroid hormone" has been suggested in March 2014 by Refetoff et al.

<span class="mw-page-title-main">Levothyroxine</span> Thyroid hormone

Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T4). It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. It may also be used to treat and prevent certain types of thyroid tumors. It is not indicated for weight loss. Levothyroxine is taken orally (by mouth) or given by intravenous injection. Levothyroxine has a half-life of 7.5 days when taken daily, so about six weeks is required for it to reach a steady level in the blood.

<span class="mw-page-title-main">Thyroid disease</span> Medical condition

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Thyroid storm is a rare but severe and life-threatening complication of hyperthyroidism. It occurs when overactive thyroid activity leads to hypermetabolism, the end result being death from cardiac arrest or multiple organ failure.

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Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T3). It is most commonly used to treat hypothyroidism and myxedema coma. It can be taken by mouth or by injection into a vein.

Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. TFTs may be requested if a patient is thought to suffer from hyperthyroidism or hypothyroidism, or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy. It is also requested routinely in conditions linked to thyroid disease, such as atrial fibrillation and anxiety disorder.

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<span class="mw-page-title-main">Reverse triiodothyronine</span> Chemical compound

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<span class="mw-page-title-main">Allan–Herndon–Dudley syndrome</span> Medical condition

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Myxedema coma is an extreme or decompensated form of hypothyroidism and while uncommon, is potentially lethal. A person may have laboratory values identical to a "normal" hypothyroid state, but a stressful event precipitates the myxedema coma state, usually in the elderly. Primary symptoms of myxedema coma are altered mental status and low body temperature. Low blood sugar, low blood pressure, hyponatremia, hypercapnia, hypoxia, slowed heart rate, and hypoventilation may also occur. Myxedema, although included in the name, is not necessarily seen in myxedema coma. Coma is also not necessarily seen in myxedema coma, as patients may be obtunded without being comatose.

<span class="mw-page-title-main">Thyroid hormones</span> Hormones produced by the thyroid gland

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Liotrix is a 4:1 mixture of thyroxine (T4) and triiodothyronine (T3) made synthetically. It is used to replenish thyroid hormones in thyroid deficiency and hypothyroidism. The only brand of liotrix available in the U.S. is Thyrolar, manufactured by Forest Laboratories.

Kent Holtorf is an American physician and entrepreneur practicing in Los Angeles, California. He is a board examiner of the American Board of Anti-Aging Medicine (ABAAM), which is not recognized by established medical organizations. He is the founder and medical director of Holtorf Medical Group, a practice with five centers that offer treatment for conditions including fibromyalgia, adrenal fatigue, complex endocrine dysfunction, hypothyroidism, age management, chronic fatigue syndrome, low libido, chronic Lyme disease, migraines, PMS, perimenopause and menopause. His practice focuses on alternative therapies that are not recognised as effective. He has been criticized in the media for his controversial views on topics like bioidentical hormone replacement therapy and vaccines.

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References

  1. Nippoldt, Todd (November 21, 2009). "Is Wilson's Syndrome a legitimate ailment?". Mayo Clinic . Retrieved April 9, 2010.
  2. "Public Health Statement: "Wilson's Syndrome"". American Thyroid Association. 24 May 2005.
  3. 1 2 "Board:Physician is fleecing patients". Lakeland Ledger. February 9, 1992. Retrieved 2010-05-27. A physician fleeced patients and insurers with treatments for a phony syndrome he named for himself, said a state medical board that suspended the doctor's license for six months.
  4. Wilson, E. Denis (1992). Wilson's Temperature Syndrome - A Reversible Low Temperature Problem. Cornerstone Publishing. ISBN   0-9708510-1-4.
  5. Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, et al. (June 2008). "Hypothermia therapy after traumatic brain injury in children". The New England Journal of Medicine. 358 (23): 2447–56. doi: 10.1056/NEJMoa0706930 . PMID   18525042.
  6. Pryor JA, Prasad AS (2008). Physiotherapy for Respiratory and Cardiac Problems: Adults and Paediatrics. Elsevier Health Sciences. p. 8. ISBN   978-0702039744. Body temperature is maintained within the range 36.5-37.5 °C. It is lowest in the early morning and highest in the afternoon.
  7. Thomas, Mike (September 22, 1991). "The Wilson Syndrome". Orlando Sentinel .
  8. Ricks, Delthia (February 8, 1992). "Longwood Doctor Is Censured". Orlando Sentinel .
  9. "License Verification: E. Denis Wilson". Florida Department of Health. Retrieved April 2, 2009.
  10. Gentry, Carol (February 8, 1992). "Doctor's syndrome a sham, board says". St. Petersburg Times . Retrieved April 9, 2010.